Can a simple antibiotic or immunoglobulin shield blood cancer patients from deadly infections?

NCT ID NCT07202078

Recruiting now Disease control Sponsor: Monash University Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study compares two infection-prevention strategies in 900 people with blood cancers like myeloma and leukemia. One group gets an antibiotic (co-trimoxazole) daily, while another receives immunoglobulin infusions every few weeks. The goal is to see which approach better prevents severe infections and improves survival. The trial uses an adaptive design, allowing researchers to add new treatments as they go.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Co-trimoxazole (antibiotic) or intravenous/subcutaneous immunoglobulin
What this could lead to: If successful, this could establish a standard way to prevent life-threatening infections in people with blood cancers, reducing hospital stays and improving quality of life.
What could go wrong: This is an early-to-mid stage trial (Phase 2/3) with 900 participants. The treatments may not reduce infections as hoped, or side effects like allergies could limit their use.

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Conditions

The condition(s) this trial relates to.

Infections leukemia lymphoma neoplasm non-Hodgkin lymphoma plasma cell myeloma plasma cell neoplasm infectious disease prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LEUKEMIA MYELOMA NON-HODGKIN'S LYMPHOMA

Contacts and locations

Locations

Austin Hospital
RECRUITING

Melbourne, Victoria, 3004, Australia
Northern Health
RECRUITING

Melbourne, Victoria, 3004, Australia
Royal Adelaide Hospital
RECRUITING

Adelaide, South Australia, 5000, Australia

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