MYELOMA

This study tests a drug called belantamab mafodotin in 30 people with high-risk smoldering multiple myeloma, a condition that often leads to active cancer. The goal is to find the safest dose and see if the drug can control the disease. Participants receive the drug alone, and do…

This study looks at different ways to prevent serious infections in people with blood cancers like myeloma, leukemia, and lymphoma. About 900 participants who have been on immunoglobulin therapy for at least 6 months will either stop it, switch to antibiotics, or continue current…

This study tests whether a combination of elotuzumab, iberdomide, and dexamethasone can help control multiple myeloma that has returned or not responded to treatment, after patients have already received a CAR-T cell therapy called idecabtagene vicleucel. About 49 adults with rel…

This study tests whether a drug called elranatamab, given after CAR-T cell therapy (cilta-cel), can help people with high-risk relapsed myeloma live longer without their cancer getting worse. About 39 participants who have already received CAR-T therapy will receive elranatamab a…

This study tests different ways to prevent serious infections in people with blood cancers like myeloma, lymphoma, and leukemia. About 900 participants will receive either antibiotics or immunoglobulin therapy to see which approach works best. The goal is to reduce severe infecti…

This study tests a new treatment for people with multiple myeloma that has come back or not responded to standard therapies. The treatment uses immune cells (NK cells) from donated cord blood that are genetically modified to better recognize and attack myeloma cells. The goal is …

This early-stage study tests an experimental pill called KTX-1001 in people with multiple myeloma that has returned or not responded to at least three prior treatments. The main goals are to check safety and find the right dose, with early signs of tumor shrinkage also measured. …

This study tests different ways to prevent serious infections in people with blood cancers like myeloma, lymphoma, and leukemia. About 900 participants will receive either antibiotics or immunoglobulin to see which approach works best. The goal is to reduce severe infections and …

This study compares two common treatments—immunoglobulin and antibiotics—to see which is better at preventing serious infections in people with blood cancers like myeloma, lymphoma, or leukemia. About 900 adults will take part. The goal is to find the safest and most effective wa…

This study tests a home-based rehabilitation program for 40 adults with lymphoma or myeloma who are about to receive CAR-T cell therapy. The program includes personalized exercise and nutrition plans, monitored remotely via a web portal and smart technology. The goal is to see if…

This study looks at whether offering blood transfusions at home for people with advanced blood cancers who are in hospice care can improve their quality of life and mood. About 700 adults with relapsed or hard-to-treat blood cancers will take part. The goal is to see if this prog…

This study looks at whether people with multiple myeloma can safely give themselves a standard chemotherapy injection (bortezomib) at home, either by themselves or with a caregiver's help. About 100 adults who have already had at least four injections in a hospital will be taught…

This study is testing whether a special type of PET scan called 18F FLT can find signs of leukemia or other blood cancers after treatment. About 60 people aged 4 to 80 with relapsed or hard-to-treat leukemia or myeloma will get the scan before and after therapy. The goal is to se…

This study aims to collect blood samples (liquid biopsies) from 2,500 people with cancer or at high risk for cancer, along with their medical information. The samples will be stored and used by researchers to develop better ways to detect, monitor, and understand cancer over time…

This study looks at how services from a non-profit cancer advocacy organization affect people with blood cancers like leukemia and lymphoma. Researchers will track 400 patients over time to see if the group's programs improve access to care, quality of life, and reduce financial …