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New pill takes on tough blood cancers in first human trial

NCT ID NCT06501196

Recruiting now Disease control Sponsor: BlossomHill Therapeutics Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early-phase trial tests an experimental oral drug called BH-30236 in adults with relapsed or refractory acute myeloid leukemia (AML) or high-risk myelodysplastic syndrome (MDS). The study first tests BH-30236 alone, then in combination with another drug, venetoclax. About 170 participants will be enrolled to check safety, dosing, and any signs of anti-cancer activity.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
BH-30236 (an oral CLK inhibitor) and venetoclax
What this could lead to
If successful, this could lead to a new oral treatment option for people with hard-to-treat leukemias and related blood cancers.
What could go wrong
This is a very early, first-in-human trial with a small number of participants. The drug may not work or could cause unexpected side effects. It is not a cure.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

acute myeloid leukemia leukemia myelodysplastic syndrome Myelodysplastic Syndromes myeloid leukemia Preleukemia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LEUKEMIA LEUKEMIA, MYELOID LEUKEMIA, MYELOID, ACUTE MYELODYSPLASTIC SYNDROMES PRELEUKEMIA REFRACTORY ACUTE MYELOID LEUKEMIA

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • City of Hope Medical Center

    RECRUITING

    Duarte, California, 91010, United States

  • Fred Hutchinson Cancer Center

    RECRUITING

    Seattle, Washington, 98109, United States

  • Memorial Sloan Kettering Cancer Center

    RECRUITING

    New York, New York, 10065, United States

    Contact

  • Moffitt Cancer Center

    RECRUITING

    Tampa, Florida, 33612, United States

  • Northwestern Medicine - Northwestern Memorial Hospital Galter Pavilion

    RECRUITING

    Chicago, Illinois, 60611, United States

  • Roswell Park Cancer Institute

    RECRUITING

    Buffalo, New York, 14263, United States

  • Sarah Cannon Research Institute

    RECRUITING

    Nashville, Tennessee, 37203, United States

    Contact

  • Stanford Cancer Center

    RECRUITING

    Palo Alto, California, 94304, United States

  • Sylvester Comprehensive Cancer Center

    RECRUITING

    Miami, Florida, 33136, United States

  • The Ohio State University Wexner Medical Center - James Cancer Hosp

    RECRUITING

    Columbus, Ohio, 43210, United States

  • The University of Texas M.D. Anderson Cancer Center

    RECRUITING

    Houston, Texas, 77030, United States

  • University of California Los Angeles

    RECRUITING

    Los Angeles, California, 90095, United States

  • University of Wisconsin Clinical Science Center

    RECRUITING

    Madison, Wisconsin, 53792, United States

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