Can a monthly antibiotic shot keep kids with leukemia safer from infections?

NCT ID NCT06810583

Recruiting now Disease control Sponsor: St. Jude Children's Research Hospital Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early-phase trial is testing whether a long-acting antibiotic called dalbavancin, given once every 28 days along with a short course of oral antibiotics, can prevent serious bloodstream infections in children and young adults with high-risk leukemia. The study will enroll 29 participants receiving chemotherapy that causes prolonged low white blood cell counts. Researchers will measure how many develop infections, how well the drug is tolerated, and how acceptable the treatment schedule is to patients.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Dalbavancin (an antibiotic given by IV every 28 days, plus a fluoroquinolone antibiotic by mouth for the first 28 days)
What this could lead to: If it works, this could point toward a new way to prevent dangerous bloodstream infections in children with leukemia during chemotherapy.
What could go wrong: This is a very small, early-phase trial with only 29 participants and no comparison group, so results may not apply broadly. The antibiotic combination may also cause side effects or not prevent infections as hoped.

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Conditions

The condition(s) this trial relates to.

acute lymphoblastic leukemia acute myeloid leukemia childhood acute lymphoblastic leukemia leukemia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE MYELOID LEUKEMIA LEUKEMIA LYMPHOBLASTIC LEUKEMIA IN CHILDREN

Contacts and locations

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Study contacts

Contact

Email: •••••@•••••

Locations

St. Jude Children's Research Hospital
RECRUITING

Memphis, Tennessee, 38105, United States

Contact Email: •••••@•••••

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