MYELODYSPLASTIC SYNDROMES

This study is testing a method to process stem cell transplants for patients with a serious blood disorder called myelodysplastic syndrome (MDS). The goal is to reduce a common and dangerous complication called graft-versus-host disease (GVHD), where the donor's immune cells atta…

This study is testing whether a pill called oral azacitidine can help control a type of early-stage blood cancer called myelodysplastic syndrome (MDS). About 230 people with low or intermediate-risk MDS will take either the pill or a placebo, along with standard supportive care. …

This study aims to collect long-term safety information on the drug sabatolimab for patients with certain blood cancers. It is for patients who have already been receiving sabatolimab in a previous Novartis study and are still benefiting from it. The main goal is to monitor for a…

This is the first study in people to test a new oral pill called NTX-301. It aims to see if the drug is safe and can help control advanced forms of leukemia and related blood cancers that have come back or stopped responding to other treatments. The study will enroll about 22 adu…

This trial is testing a stem cell transplant method for people with blood cancers who don't have a perfectly matched donor. It uses stem cells from a partially matched, unrelated donor along with specific medications to prevent complications. The main goal is to see if this appro…

This study allows patients with certain blood cancers who were benefiting from ASTX727 treatment in previous trials to continue receiving the medication. The main goal is to collect long-term safety information about the drug. Participants will receive the same dose they were tak…

This study is testing a new combination of radiation and chemotherapy given before a donor stem cell transplant for patients with leukemia and related blood cancers. The goal is to see if this new approach is safe and effective at controlling the cancer while reducing complicatio…

This study is testing the effectiveness and safety of giving the highest approved dose of the drug luspatercept to people with a lower-risk form of myelodysplastic syndromes (MDS) who need regular red blood cell transfusions. The main goal is to see if the treatment can help pati…

This study is testing if a new oral pill (ASTX727) works as well as the standard intravenous (IV) drug (decitabine) for people with myelodysplastic syndromes (MDS), a serious disorder where the bone marrow doesn't make enough healthy blood cells. Researchers will compare how the …

This study tested a drug called imetelstat for people with a bone marrow disorder called myelodysplastic syndrome (MDS). The goal was to see if the drug could help patients who need regular blood transfusions and whose disease has stopped responding to standard treatments. Resear…

This study is testing if using a lower dose of a standard drug (cyclophosphamide) given after a stem cell transplant can reduce serious infections in the first 100 days. The trial aims to see if this lower dose is just as good at preventing graft-versus-host disease, a common and…

This early-stage trial is testing whether a combination of two immune-based treatments is safe for patients whose blood cancer has returned after a stem cell transplant. The study involves 25 adults with conditions like acute myeloid leukemia or myelodysplastic syndromes. Researc…

This early-stage study is testing a new drug called bexmarilimab, which works with the immune system, in combination with standard cancer treatments. It aims to find a safe dose and see if the combination helps adults with advanced forms of blood cancers like myelodysplastic synd…

This early-stage study is testing whether a drug called itacitinib can make stem cell transplants safer for older patients with blood cancers. The goal is to prevent a severe, potentially life-threatening immune reaction called cytokine release syndrome (CRS) that can occur after…

This study is testing whether combining two drugs—canakinumab and darbepoetin alfa—can help patients with lower-risk myelodysplastic syndromes (MDS) who no longer respond to standard anemia treatments. The trial will first determine the safest dose and then see if the combination…

This study is testing an investigational drug called AG-946 (tebapivat) for adults with a lower-risk form of myelodysplastic syndromes (MDS), a bone marrow disorder that causes anemia. The main goal is to see if the drug can help patients become independent from regular blood tra…

This study is testing a modified bone marrow transplant procedure for adults and children with serious blood cancers and disorders. The goal is to treat the underlying disease while reducing the risk of a dangerous complication called graft-versus-host disease. Researchers use a …

This study is testing a drug called luspatercept to see if it can help patients with a specific type of lower-risk myelodysplastic syndrome (MDS) who have anemia and require regular blood transfusions. The main goal is to see if the treatment can allow patients to go at least 8 w…

This study is testing if adding a drug called vorinostat to standard medications can better prevent graft-versus-host disease (GVHD) in children and young adults getting a bone marrow transplant for blood cancers. GVHD is a serious complication where the donor's immune cells atta…

This study is testing whether adding a precise, targeted form of radiation to the standard pre-transplant drug regimen can improve outcomes for adults with high-risk forms of acute myeloid leukemia (AML) or myelodysplastic syndromes (MDS). The goal is to better prepare the body t…

This early-stage study aims to find a safe dose for a new combination of three drugs (navitoclax, venetoclax, and decitabine) to treat aggressive forms of blood and bone marrow cancers. It will enroll about 36 adults with specific high-risk conditions like acute myeloid leukemia …

This study is testing if giving a special 'priming' drug for five days before standard chemotherapy helps children and young adults with acute myeloid leukemia (AML). The goal is to see if this approach is safe and if it makes the chemotherapy more effective at controlling the ca…

This early-stage trial aimed to test the safety of a new bone marrow transplant method for adults with leukemia and related blood cancers. It planned to use frozen bone marrow tissue from deceased, partially matched donors, combined with specific medications to prevent complicati…

This study is testing whether the drug eltrombopag can help Japanese adults with a specific type of lower-risk myelodysplastic syndrome (MDS) become independent from needing regular platelet transfusions. It compares the drug against a placebo in a small group of 36 participants.…

This study is testing if a new pill form of the cancer drug cladribine works similarly to the standard version given through an IV. It involves 40 adults with specific types of leukemia. The main goal is to find the right pill dose that delivers the same amount of drug into the b…

This early-stage study is testing whether immune cells from healthy donors, given along with two other drugs, are safe for people with advanced colorectal, stomach, or hard-to-treat blood cancers. The goal is to see if this combination helps the donor immune cells last longer in …

This study is testing a new electronic program that combines mindfulness and music therapy. It aims to help patients feel better and manage symptoms during and after a difficult stem cell transplant for blood cancers. The research will see if this program improves quality of life…

This study is testing whether adding a specialized palliative care team to standard cancer treatment improves the experience for patients with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS). The palliative care team focuses on managing pain, fatigue, anxiety, and …

This study aims to discover what causes blood and bone marrow cancers like leukemia. Researchers will analyze cancer cells from up to 5,000 participants to find the specific abnormalities that make the cells grow. The goal is to use this knowledge to develop more effective and le…

This study aimed to understand how severe COVID-19 disrupts the body's ability to make new blood cells, a process called emergency hematopoiesis. Researchers planned to compare blood cell samples from three groups: patients with severe COVID-19, patients with certain chronic bloo…

This study aims to understand how muscle strength and body composition affect recovery and long-term health in people with blood cancers who receive a stem cell transplant. Researchers will observe 144 patients to see if their muscle health at the time of transplant can predict c…

This study aims to understand what happens to people diagnosed with early-stage blood cell disorders called ICUS and CCUS. Researchers will follow 300 patients in China over time to see if and how these conditions progress to more serious blood diseases like myelodysplastic syndr…

This study aims to see if testing cancer cells in a lab dish can predict which chemotherapy drugs will work best for patients with acute myeloid leukemia (AML) or myelodysplastic syndromes (MDS). Researchers will collect blood samples from 80 adults before and after they start st…

This study aims to understand the genetic and molecular changes that cause bone marrow failure diseases, where the body stops making enough blood cells. Researchers will analyze blood and bone marrow samples from about 1,400 patients with these conditions to see how specific gene…

This study tracks the long-term safety of experimental cancer treatments in patients who previously participated in earlier Janssen trials. It follows 80 people with various cancers to monitor for serious side effects over time. The goal is to better understand the safety profile…

This study aims to find out how common a specific enzyme problem is in people with certain blood cancers and unexplained anemia. Researchers will take one blood sample from about 100 participants who have conditions like myelodysplastic syndrome (MDS) or other related disorders. …