Radiation boost may help stem cell transplants beat tough leukemia
NCT ID NCT03121014
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This phase II trial tests whether adding targeted total marrow irradiation to standard chemotherapy before a stem cell transplant can help prevent relapse in people with high-risk acute myeloid leukemia or myelodysplastic syndromes. About 38 adults aged 18–65 will receive the combined treatment. The main goal is to see if more patients survive one year without their cancer returning.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Fludarabine, Busulfan, ATG, Tacrolimus, and total marrow irradiation
- What this could lead to
- If successful, this could improve the chance of staying cancer-free after a stem cell transplant for people with hard-to-treat leukemia or myelodysplastic syndromes.
- What could go wrong
- This is a small, early-phase study (38 participants) with no control group. The intense treatment carries serious risks like infection, organ damage, and graft-versus-host disease. Results may not apply to all patients.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
University of Illinois at Chicago
Chicago, Illinois, 60612, United States
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