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New hope for MDS anemia: luspatercept vs standard care in phase 3 trial

NCT ID NCT05949684

Ongoing Disease control Sponsor: Bristol-Myers Squibb Source: ClinicalTrials.gov ↗

First seen Nov 01, 2025 · Last updated Jun 05, 2026 · Updated 28 times

Summary

This study tests whether luspatercept works better than epoetin alfa for treating anemia in adults with a certain type of low-risk MDS who have not needed blood transfusions or prior anemia drugs. About 360 participants will receive one of the two drugs, and researchers will track how many need transfusions over 96 weeks. The goal is to see which drug better prevents the need for regular blood transfusions.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • Halifax Health Medical Center

    Daytona Beach, Florida, 32114, United States

  • Local Institution - 0003

    São Paulo, 05403-000, Brazil

  • Local Institution - 0007

    Bethesda, Maryland, 20817, United States

  • Local Institution - 0009

    Buenos Aires, C1426ANZ, Argentina

  • Local Institution - 0010

    Buenos Aires, C1425DND, Argentina

  • Local Institution - 0011

    Nice, Alpes-Maritimes, 06202, France

  • Local Institution - 0012

    Buenos Aires, CP1280AEB, Argentina

  • Local Institution - 0015

    Paris, 75010, France

  • Local Institution - 0016

    Pessac, Aquitaine, 33600, France

  • Local Institution - 0017

    Toronto, Ontario, M4N 3M5, Canada

  • Local Institution - 0019

    Tours, Indre-et-Loire, 37032, France

  • Local Institution - 0021

    Nyíregyháza, Szabolcs-Szatmár-Bereg, 4400, Hungary

  • Local Institution - 0024

    Eger, Heves County, 3300, Hungary

  • Local Institution - 0026

    Budapest, 1088, Hungary

  • Local Institution - 0028

    Berlin, 14195, Germany

  • Local Institution - 0029

    Hangzhou, Zhejiang, 310003, China

  • Local Institution - 0030

    Beijing, Beijing Municipality, 100730, China

  • Local Institution - 0032

    Nanjing, Jiangsu, 210029, China

  • Local Institution - 0033

    Wenzhou, Zhejiang, 32500, China

  • Local Institution - 0038

    Harbin, Heilongjiang, 150010, China

  • Local Institution - 0043

    Changchun, Jilin, 130021, China

  • Local Institution - 0044

    Covington, Louisiana, 70433, United States

  • Local Institution - 0048

    Shenyang, Liaoning, 110001, China

  • Local Institution - 0049

    Calgary, Alberta, T2N 5G2, Canada

  • Local Institution - 0050

    London, Ontario, N6A 5W9, Canada

  • Local Institution - 0052

    Heidelberg, Victoria, 3084, Australia

  • Local Institution - 0054

    Clayton, Victoria, 3168, Australia

  • Local Institution - 0056

    Rio de Janeiro, 20211-030, Brazil

  • Local Institution - 0059

    Fortaleza, Ceará, 60430-270, Brazil

  • Local Institution - 0060

    Gdansk, 80-952, Poland

  • Local Institution - 0061

    Katowice, 40-519, Poland

  • Local Institution - 0062

    Warsaw, 02-172, Poland

  • Local Institution - 0069

    Huixquilucan, State of Mexico, 52787, Mexico

  • Local Institution - 0070

    Clovis, California, 93611, United States

  • Local Institution - 0071

    Blacktown, New South Wales, 2148, Australia

  • Local Institution - 0075

    Chengdu, Sichuan, 610041, China

  • Local Institution - 0076

    Reggio Calabria, 89133, Italy

  • Local Institution - 0079

    Nanchang, Jiangxi, 330006, China

  • Local Institution - 0080

    Brno, Brno-město, 625 00, Czechia

  • Local Institution - 0082

    Alexandroupoli, Anatolikí Makedonía Kai Thráki, 681 00, Greece

  • Local Institution - 0083

    Suzhou, Jiangsu, 215006, China

  • Local Institution - 0084

    Athens, Attikí, 115 27, Greece

  • Local Institution - 0085

    Turin, Piedmont, 10128, Italy

  • Local Institution - 0089

    Changsha, Hunan, 410008, China

  • Local Institution - 0090

    Prague, 12808, Czechia

  • Local Institution - 0092

    Ostrava, Moravian-Silesian Region, 708 52, Czechia

  • Local Institution - 0101

    Porto Alegre, Rio Grande do Sul, 90610-000, Brazil

  • Local Institution - 0103

    Tianjin, Tianjin Municipality, 300020, China

  • Local Institution - 0106

    Tampa, Florida, 33612, United States

  • Local Institution - 0108

    Wuhan, Hubei, 430058, China

  • Local Institution - 0109

    Hefei, Anhui, 230001, China

  • Local Institution - 0111

    Qingdao, Shandong, 266003, China

  • Local Institution - 0112

    Vancouver, British Columbia, V6Z 1Y6, Canada

  • Local Institution - 0113

    Camperdown, New South Wales, 2050, Australia

  • Local Institution - 0116

    La Tronche, Isère, 38700, France

  • Local Institution - 0128

    Hattiesburg, Mississippi, 39401, United States

  • Local Institution - 0130

    Wałbrzych, Lower Silesian Voivodeship, 58-309, Poland

  • Local Institution - 0131

    Chaïdári, Attikí, 12462, Greece

  • Local Institution - 0132

    Pátrai, Achaḯa, 26504, Greece

  • Local Institution - 0133

    Verona, 37134, Italy

  • Local Institution - 0134

    Milan, Milano, 20162, Italy

  • Local Institution - 0135

    Bologna, 40138, Italy

  • Local Institution - 0136

    Rozzano, Milano, 20089, Italy

  • Local Institution - 0137

    Milan, Lombardy, 20122, Italy

  • Local Institution - 0138

    Florence, Tuscany, 50134, Italy

  • Local Institution - 0140

    Toulouse, 31100, France

  • Local Institution - 0142

    Mexico City, 14080, Mexico

  • Local Institution - 0147

    Medellín, Antioquia, 05034, Colombia

  • Local Institution - 0149

    Montería, 230002, Colombia

  • Local Institution - 0150

    Puebla City, 72424, Mexico

  • Local Institution - 0152

    Valledupar, Cesar Department, 200001, Colombia

  • Local Institution - 0156

    Oaxaca City, Oaxaca, 68020, Mexico

  • Local Institution - 0163

    Plantation, Florida, 33322, United States

  • Local Institution - 0165

    Vandœuvre-lès-Nancy, Lorraine, 54511, France

  • Local Institution - 0166

    Würzburg, 97080, Germany

  • Local Institution - 0167

    Mutlangen, 73557, Germany

  • Local Institution - 0168

    Koblenz, Rhineland-Palatinate, 56068, Germany

  • Local Institution - 0169

    Berlin, 10117, Germany

  • Local Institution - 0171

    Leipzig, Saxony, 04103, Germany

  • Local Institution - 0173

    New Haven, Connecticut, 06510, United States

  • Local Institution - 0174

    Knoxville, Tennessee, 37920, United States

  • Local Institution - 0177

    Bengaluru, Karnataka, 560027, India

  • Local Institution - 0178

    Bhubaneswar, Odisha, 751003, India

  • Local Institution - 0179

    Fountain Valley, California, 92708, United States

  • Local Institution - 0180

    Jacksonville, Florida, 32207, United States

  • Local Institution - 0183

    Walnut Creek, California, 94598, United States

  • Local Institution - 0184

    Skokie, Illinois, 60077, United States

  • Local Institution - 0191

    Baton Rouge, Louisiana, 70808, United States

  • Local Institution - 0193

    New Delhi, National Capital Territory of Delhi, 110029, India

  • Local Institution - 0194

    Zhengzhou, Henan, 450003, China

  • Local Institution - 0196

    Valencia, Valenciana, Comunitat, 46010, Spain

  • Local Institution - 0197

    L'Hospitalet de Llobregat, Catalunya [Cataluña], 08908, Spain

  • Local Institution - 0198

    Barcelona, Barcelona [Barcelona], 08035, Spain

  • Local Institution - 0199

    Granada, 18012, Spain

  • Local Institution - 0200

    Salamanca, 37007, Spain

  • Local Institution - 0201

    St. Petersburg, Florida, 33705, United States

  • Local Institution - 0202

    Fort Myers, Florida, 33901, United States

  • Local Institution - 0203

    Kennewick, Washington, 99336, United States

  • Local Institution - 0206

    Columbus, Ohio, 43210, United States

  • Local Institution - 0207

    Düsseldorf, 40225, Germany

  • Local Institution - 0209

    Oxnard, California, 93030, United States

  • Local Institution - 0211

    Los Alamitos, California, 90720, United States

  • Local Institution - 0212

    Hackensack, New Jersey, 07601, United States

  • Local Institution - 0216

    Xi’an, Shanxi, 710068, China

  • Local Institution - 0217

    Beijing, Beijing Municipality, 100044, China

  • Local Institution - 0218

    Shanghai, Shanghai Municipality, 200030, China

  • Local Institution - 0219

    San Juan, 00917, Puerto Rico

  • Local Institution - 0220

    Xiamen, Fujian, 361003, China

  • Local Institution - 0222

    Saint Louis Park, Minnesota, 55426, United States

  • Local Institution - 0223

    Chongqing, Chongqing Municipality, 400016, China

  • Local Institution - 0224

    Margate, Florida, 33063, United States

  • Local Institution - 0227

    Hartford, Connecticut, 06102, United States

  • Local Institution - 0228

    Houston, Texas, 77030, United States

  • Local Institution - 0229

    Roanoke, Virginia, 24014, United States

  • Local Institution - 0235

    New Delhi, National Capital Territory of Delhi, 110085, India

  • Local Institution - 0236

    Richmond, Virginia, 23219, United States

  • Local Institution - 0238

    Tamarac, Florida, 33321, United States

  • Local Institution - 0240

    Honolulu, Hawaii, 96813, United States

  • Local Institution - 0243

    Ahmedabad, Gujarat, 380009, India

  • Local Institution - 0244

    Roma, 00168, Italy

  • Local Institution - 0245

    Athens, Attikí, 11527, Greece

  • Local Institution - 0246

    Gold Coast, Queensland, 4217, Australia

  • Local Institution - 0247

    Orange, California, 92868, United States

  • Local Institution - 0248

    Villejuif, Val-de-Marne, 94805, France

  • Local Institution - 0251

    Jena, Thuringia, 07747, Germany

  • Local Institution - 0252

    Madrid, 28006, Spain

  • Local Institution - 0254

    Coffs Harbour, New South Wales, 2450, Australia

  • Local Institution - 0255

    Lübeck, 23562, Germany

  • Local Institution - 0256

    Rome, Lazio, 00133, Italy

  • Local Institution - 0258

    Los Angeles, California, 90095, United States

  • Local Institution - 0259

    Münster, North Rhine-Westphalia, 48153, Germany

  • Local Institution - 0261

    Erding, Bavaria, 85435, Germany

  • Local Institution - 0266

    Shijiazhuang, Hebei, 050000, China

  • Local Institution - 0267

    Piedecuesta, Santander Department, 681017, Colombia

  • Local Institution - 0269

    Angers, Maine-et-Loire, 49933, France

  • Local Institution - 0270

    Dyer, Indiana, 46311, United States

  • Local Institution - 0271

    Oviedo, 33011, Spain

  • Local Institution - 0272

    Chicago, Illinois, 60611, United States

  • Local Institution - 0274

    Seville, 41013, Spain

  • Local Institution - 0276

    Santiago, Santiago Metropolitan, 7580206, Chile

  • Local Institution - 0277

    Santiago, Santiago Metropolitan, 8420383, Chile

  • Local Institution - 0278

    Santiago, Santiago Metropolitan, 7500921, Chile

  • Local Institution - 0280

    Santiago, Santiago Metropolitan, 7500587, Chile

  • Local Institution - 0281

    Ningbo, Zhejiang, 315010, China

Conditions

Explore the condition pages connected to this study.

MYELODYSPLASTIC SYNDROMES MYELODYSPLASTIC SYNDROMES