Blood cancer drug ASTX727 gets extended trial for ongoing patients

NCT ID NCT04093570

ENROLLING_BY_INVITATION Disease control Sponsor: Taiho Oncology, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 29, 2026 · Updated 2 times

Summary

This study offers continued treatment with the drug ASTX727 to adults with acute myeloid leukemia, chronic myelomonocytic leukemia, or myelodysplastic syndromes who were already benefiting from it in earlier studies. The main goal is to monitor long-term safety. About 332 participants will be enrolled by invitation only.

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Conditions

The condition(s) this trial relates to.

acute myeloid leukemia chronic myelomonocytic leukemia myelodysplastic syndrome Myelodysplastic Syndromes

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE MYELOID LEUKEMIA CHRONIC MYELOMONOCYTIC LEUKEMIA MYELODYSPLASTIC SYNDROMES

Contacts and locations

Locations

Baylor Scott White University Medical Center

Dallas, Texas, 75246, United States
Boca Raton Clinical Research

Plantation, Florida, 33322, United States
Cancer and Hematology Centers for Western Michigan

Grand Rapids, Michigan, 49503, United States
Centrum Badań Klinicznych Piotr Napora Lekarze Sp. p.

Wroclaw, Lower Silesian Voivodeship, Poland
Charleston Hematology Oncology Associates

Charleston, South Carolina, 29414, United States
Clínica Universidad de Navarra - Madrid

Madrid, 28027, Spain
Compassionate Care Research Group

Fountain Valley, California, 92708, United States
Debreceni Egyetem Klinikai Kozpont, Belgyogyszati Klinika, B epulet, Hematologia

Debrecen, 4032, Hungary
Erebuni Medical Center

Yerevan, Armenia
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico

Milan, 20122, Italy
Gabrail Cancer Center Research

Canton, Ohio, 44718, United States
Gabrail Cancer Center Research - 06 FE Study

Canton, Ohio, 44718, United States
Hackensack Medical Center

Hackensack, New Jersey, 07601, United States
Hackensack Medical Center - 06 FE Study

Hackensack, New Jersey, 07601, United States
Hematology Center After Prof. R. Yeolyan (Adult Blood Disorders)

Yerevan, Armenia
Hematology Center After Prof. R. Yeolyan (Clinic of Adults Oncology)

Yerevan, Armenia
Hospital Clínico Universitario Virgen de la Arrixaca

Murcia, 30120, Spain
Hospital Universitari Arnau de Vilanova

Lleida, Spain
Hospital Universitario 12 de Octubre

Madrid, 28041, Spain
Hospital Universitario La Fe

Valencia, 46026, Spain
Hôpital Emile Muller

Mulhouse, Grand Est, 68100, France
Institutul Oncologic Bucuresti - Prof. Dr. Alexandru Trestioreanu

Bucharest, 22328, Romania
Institutul Oncologic Prof. Dr. Ion Chiricuta

Cluj-Napoca, 400015, Romania
Kadlec Clinic Hematology and Oncology

Kennewick, Washington, 99336, United States
May Cancer Center

San Antonio, Texas, 78229, United States
Mayo - Rochester

Rochester, Minnesota, 55905, United States
National Center of Oncology Named After V.A. Fanarjyan

Yerevan, Armenia
Oregon Health and Science University

Portland, Oregon, 92739, United States
Princess Margaret Cancer Center

Toronto, M5G 2M9, Canada
QEII Health Sciences Centre

Nova Scotia, B3H 2Y9, Canada
Rosewell Park Cancer Institute

Buffalo, New York, 14263, United States
Roswell Park Cancer Institute - 06 FE Study

Buffalo, New York, 14263, United States
Seattle Cancer Care Alliance/Fred Hutchinson Cancer Research Center

Seattle, Washington, 98109, United States
Specialized Hospital for Active Treatment of Hematological Disease EAD

Sofia, 1797, Bulgaria
Städtisches Klinikum Braunschweig

Braunschweig, Lower Saxony, 38114, Germany
Summit Clinical Research s.r.o

Bratislava, 83101, Slovakia
Sunnybrook Health Sciences Centre

Toronto, M4N 3M5, Canada
The Ottawa Hosptial

Ottawa, K1H 8L6, Canada
The Sidney Kimmel Comprehensive Cancer Center at John Hopkins

Baltimore, Maryland, 21231, United States
The University of Chicago Medical Center

Chicago, Illinois, 60637, United States
The University of Texas MD Anderson Cancer Center

Houston, Texas, 77030, United States
University of Alberta Hospital

Edmonton, T6G 2B7, Canada
University of Texas Southwestern Medical Center

Dallas, Texas, 75390, United States
Universitätsklinikum Schleswig-Holstein - Campus Lübeck

Lübeck, Schleswig-Holstein, 23538, Germany
Vanderbilt - Ingram Cancer Center

Nashville, Tennessee, 37232, United States
Wiener Gesundheitsverbund - Klinik Hietzing 06 FE Study

Vienna, 1130, Austria
Wiener Gesundheitsverbund - Klinik Hietzing 06 Study

Vienna, 1130, Austria

More trials for these conditions

Other studies related to the condition(s) this trial covers.