Could a Pre-Chemo 'Priming' drug boost leukemia survival in kids?
NCT ID NCT03164057
First seen Jan 28, 2026 · Last updated Jun 10, 2026 · Updated 19 times
Summary
This study tests whether giving a drug that changes how DNA is read (called a DNA methyltransferase inhibitor) before standard chemotherapy can help children with newly diagnosed acute myeloid leukemia. About 206 participants will receive either azacitidine or decitabine for five days before their chemo blocks. Researchers will check if this approach is safe and if it reduces the chance of the cancer coming back.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Children's Hospital of Central California
Madera, California, 93636, United States
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Children's Hospital of Michigan
Detroit, Michigan, 48201, United States
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Children's Hospital of Orange County
Orange, California, 92968, United States
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Cook Children's Medical Center
Fort Worth, Texas, 76104, United States
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Dana-Farber Cancer Institute
Boston, Massachusetts, 02215, United States
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Lucile Packard Children's Hospital Stanford University
Palo Alto, California, 94304, United States
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Rady Children's Hospital and Health Center
San Diego, California, 92123, United States
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Sanford Children's Specialty Clinic
Sioux Falls, South Dakota, 57117, United States
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St. Jude Children's Research Hospital
Memphis, Tennessee, 38105, United States
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University of Chicago Children's Hospital (Comer)
Chicago, Illinois, 60637, United States
Conditions
Explore the condition pages connected to this study.