New anemia drug for MDS and myeloma patients shows early promise but trial halted

NCT ID NCT04582539

Terminated Disease control Sponsor: Incyte Corporation Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested a daily pill called INCB000928 for people with anemia caused by myelodysplastic syndromes (MDS) or multiple myeloma. The goal was to see if it was safe and could raise red blood cell levels, reducing the need for transfusions. The trial was terminated early after enrolling only 22 participants, so we have limited information on how well it works.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: INCB000928
What this could lead to: If successful, this drug could help reduce or eliminate the need for blood transfusions in people with anemia from MDS or multiple myeloma.
What could go wrong: This was a very early (Phase 1/2) trial that was terminated before completion, so we have little data on safety or effectiveness. The drug may not work or could have side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

anemia myelodysplastic syndrome Myelodysplastic Syndromes plasma cell myeloma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ANEMIA MULTIPLE MYELOMA MYELODYSPLASTIC SYNDROMES

Contacts and locations

Locations

Azienda Ospedaliero-Universitaria Careggi (Aouc)

Florence, 50134, Italy
Barbara Ann Karmanos Cancer Hospital

Detroit, Michigan, 48201, United States
Centre Hospitalier Universitaire de Nantes (Chu de Nantes) - Hotel-Dieu

Nantes, 44093, France
Comitato Di Bioetica Della Fondazione Irccs Policlinico San Matteo

Pavia, 27100, Italy
Florida Cancer Specialists

Sarasota, Florida, 34232, United States
Hospices Civils de Lyon Centre Hospitalier Lyon Sud

Pierre-Bénite, 69310, France
Institut Gustave Roussy

Villejuif, 94800, France
Irccs Istituto Clinico Humanitas

Rozzano, 20089, Italy
L Azienda Ospedaliero-Universitaria Di Bologna Policlinico S. Orsola - Malpighi

Bologna, 40138, Italy
Md Anderson Cancer Center

Houston, Texas, 77030, United States
Stanford Cancer Center

Palo Alto, California, 94304, United States
Tulane Comprehensive Cancer Center

New Orleans, Louisiana, 70112, United States
University of Cincinnati

Cincinnati, Ohio, 45219, United States
University of Miami

Miami, Florida, 33136, United States
Vanderbilt University Medical Center

Nashville, Tennessee, 37232, United States

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