Experimental combo for tough blood cancers hits early hurdle

NCT ID NCT04937166

Terminated Disease control Sponsor: Kahr Medical Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early-stage trial tested a new drug called DSP107 combined with standard chemotherapy drugs (azacitidine and venetoclax) in 25 people with relapsed or hard-to-treat acute myeloid leukemia, myelodysplastic syndrome, or chronic myelomonocytic leukemia. The study aimed to check safety and find the right dose, but it was terminated early. It is too soon to know if this approach will help patients.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: DSP107 (a fusion protein) combined with azacitidine and venetoclax
What this could lead to: If successful, this could point toward a new combination treatment for certain blood cancers that have not responded to prior therapy.
What could go wrong: This was a very early (Phase 1) trial that was terminated, so results are limited. The combination may cause significant side effects, and it is unclear if it will work better than existing options.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

acute myeloid leukemia chronic myelomonocytic leukemia myelodysplastic syndrome Myelodysplastic Syndromes

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE MYELOID LEUKEMIA CHRONIC MYELOMONOCYTIC LEUKEMIA MYELODYSPLASTIC SYNDROMES

Contacts and locations

Locations

City of Hope

Duarte, California, 91010, United States
The University of Texas MD Anderson Cancer Center, Department of Leukemia

Houston, Texas, 77030, United States

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