New drug combo aims to boost stem cell transplant success for tough blood cancers
NCT ID NCT07044544
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This early-stage trial is testing whether adding two drugs, decitabine and venetoclax, to a standard reduced-intensity stem cell transplant can safely help control high-risk myeloid cancers like acute myeloid leukemia. About 20 adults aged 18-75 with a matched donor will receive the drugs alongside the transplant. The main goal is to find a safe dose and watch for serious side effects.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Decitabine and Venetoclax
- What this could lead to
- If this works, it could lead to a safer and more effective way to control high-risk myeloid cancers using a stem cell transplant.
- What could go wrong
- This is a very early phase 1 trial with only 20 people, so it's mainly checking safety. The added drugs may cause serious side effects, and it's too soon to know if they will improve outcomes.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
University of Alabama at Birmingham
RECRUITINGBirmingham, Alabama, 35294, United States
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Other studies related to the condition(s) this trial covers.
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