Exercise plus supplement may rebuild muscle in young transplant survivors

NCT ID NCT05194397

Recruiting now Disease control Sponsor: Children's Hospital of Philadelphia Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether a tailored exercise program combined with a dietary supplement called nicotinamide riboside (NR) can improve muscle mass, strength, and fitness in adolescents and young adults who had a bone marrow transplant for leukemia or other blood disorders. About 80 participants, aged 10 to 30, will be randomly assigned to receive NR or a placebo, and some will also do intensive exercise. The goal is to see if these interventions can reverse the muscle loss and reduced fitness that often follow transplant.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Nicotinamide Riboside (a vitamin B3-like dietary supplement)
What this could lead to: If it works, this could point toward a way to help young cancer survivors regain lost muscle strength and fitness after a bone marrow transplant.
What could go wrong: This is a small, early-phase trial (80 people) testing a supplement and exercise program. The supplement is not a proven treatment, and results may not apply to everyone.

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Conditions

The condition(s) this trial relates to.

acute lymphoblastic leukemia aplastic anemia myelodysplastic syndrome Myelodysplastic Syndromes myeloid leukemia Precursor Cell Lymphoblastic Leukemia-Lymphoma Sarcopenia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

APLASTIC ANEMIA CANCER SURVIVORS LYMPHOBLASTIC LEUKEMIA MYELODYSPLASTIC SYNDROMES MYELOID LEUKEMIA

Contacts and locations

Locations

Children's Hospital of Philadelphia
RECRUITING

Philadelphia, Pennsylvania, 19104, United States
City of Hope Medical Center
RECRUITING

Duarte, California, 91010, United States
St. Jude Children's Research Hospital
RECRUITING

Memphis, Tennessee, 38105, United States

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