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Engineered donor cells aim to make stem cell transplants safer for blood cancer patients

NCT ID NCT03802695

Recruiting now Disease control Sponsor: Orca Biosystems, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 02, 2026 · Updated 2 times

Summary

This study tests a new way to prepare donor stem cells (called Orca-Q) for people with blood cancers like leukemia or MDS who need a transplant. The goal is to see if this engineered graft is safe and helps the body accept the new cells with fewer complications. About 300 participants will receive the treatment and be monitored for side effects and how well the new cells take hold.

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Conditions

The condition(s) this trial relates to.

acute biphenotypic leukemia acute lymphoblastic leukemia acute myeloid leukemia mixed phenotype acute leukemia myelodysplastic syndrome Myelodysplastic Syndromes Precursor Cell Lymphoblastic Leukemia-Lymphoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE LYMPHOBLASTIC LEUKEMIA ACUTE MYELOID LEUKEMIA MIXED PHENOTYPE ACUTE LEUKEMIA MYELODYSPLASTIC SYNDROMES

Contacts and locations

Study contacts

  • Contact

    Email: •••••@•••••

  • Contact

    Email: •••••@•••••

Locations

  • City of Hope

    RECRUITING

    Duarte, California, 91010, United States

  • Emory University

    ACTIVE_NOT_RECRUITING

    Atlanta, Georgia, 30322, United States

  • Fred Hutchinson Cancer Center

    RECRUITING

    Seattle, Washington, 98109, United States

  • Froedtert Memorial Lutheran Hospital

    WITHDRAWN

    Milwaukee, Wisconsin, 53226, United States

  • John Theurer Cancer Center at Hackensack University Medical Center

    RECRUITING

    Hackensack, New Jersey, 07601, United States

  • Memorial Sloan Kettering Cancer Center

    RECRUITING

    New York, New York, 10065, United States

  • Moffitt Cancer Center

    RECRUITING

    Tampa, Florida, 33612, United States

  • Ohio State University

    ACTIVE_NOT_RECRUITING

    Columbus, Ohio, 43210, United States

  • Stanford Health Care

    RECRUITING

    Stanford, California, 94305, United States

  • The University of Kansas Hospital

    WITHDRAWN

    Kansas City, Kansas, 66160, United States

  • UC Davis

    RECRUITING

    Sacramento, California, 95817, United States

  • University of Texas MD Anderson Cancer Center

    RECRUITING

    Houston, Texas, 77054, United States

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