New drug aims to boost red blood cells in MDS patients

NCT ID NCT04419649

Recruiting now Disease control Sponsor: Takeda Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a drug called elritercept (KER-050) in 160 adults with a bone marrow condition called myelodysplastic syndromes (MDS) who have anemia. The main goals are to check the drug's safety and how well people tolerate different doses. Researchers will also see if it helps the body make more healthy red blood cells and reduces the need for transfusions.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: elritercept (also called KER-050 or TAK-226)
What this could lead to: If successful, this could lead to a new treatment option for anemia in people with lower-risk MDS, potentially reducing the need for blood transfusions.
What could go wrong: This is an early-phase trial with only 160 participants, so results may not apply to everyone. The drug may cause side effects or fail to improve anemia significantly.

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Conditions

The condition(s) this trial relates to.

chronic myelomonocytic leukemia Cytopenia myelodysplastic syndrome Myelodysplastic Syndromes pancytopenia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CYTOPENIA MYELODYSPLASTIC SYNDROMES

Contacts and locations

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Study contacts

Contact

Email: •••••@•••••

Locations

Austin Health
RECRUITING

Heidelberg, Victoria, 3084, Australia
Ballarat Oncology & Haematology Service
COMPLETED

Wendouree, Victoria, 3355, Australia
Border Medical Oncology Research
RECRUITING

Albury, New South Wales, 2640, Australia
Boxhill Hospital
RECRUITING

Box Hill, Victoria, 3128, Australia
CH Rene-Dubos
RECRUITING

Pontoise, France
CHU Angers - Hopital Hotel Dieu
COMPLETED

Angers, France
CHU Nice - Hopital de l'Archet 1
RECRUITING

Nice, France
CHU de Bordeaux - Hopital Haut-Leveque
RECRUITING

Talence, France
CHU de Nantes - Hotel Dieu
RECRUITING

Nantes, France
Centre Hospitalier de la Region dAnnecy
COMPLETED

Épagny, France
Charite-Campus Benjamin Franklin
NOT_YET_RECRUITING

Berlin, Germany
City of Hope National Medical Center
RECRUITING

Duarte, California, 91010, United States
Fakultni nemocnice Brno
COMPLETED

Brno, Czechia
Fakultni nemocnice Kralovske Vinohrady
RECRUITING

Prague, Czechia
Flinders Medical Centre
RECRUITING

Bedford Park, South Australia, 5042, Australia
H. Lee Moffitt Cancer Center and Research Center
RECRUITING

Tampa, Florida, 33612, United States
Hopital Saint-Louis
RECRUITING

Paris, France
Hospital Universitari i Politecnic La Fe
RECRUITING

Valencia, Spain
Hospital Universitario Central de Asturias
RECRUITING

Barcelona, Spain
Hospital Universitario Vall d'Hebron
RECRUITING

Barcelona, Spain
Hospital Universitario Virgen del Rocio
COMPLETED

Seville, Spain
Hospital Universitario de Salamanca
RECRUITING

Salamanca, Spain
ICO l'Hospitalet - Hospital Duran i Reynals
RECRUITING

Barcelona, Spain
Karmanos Cancer Institute at Mclaren Greater Lansing
COMPLETED

Lansing, Michigan, 48910, United States
Klinikum Bayreuth GmbH
RECRUITING

Bayreuth, Germany
Klinikum Esslingen GmbH
RECRUITING

Esslingen am Neckar, Germany
Marien Hospital Dusseldorf GMBH
RECRUITING

Düsseldorf, Germany
Middlemore Hospital
COMPLETED

Auckland, 2025, New Zealand
Praxis am Volkspark Berlin
NOT_YET_RECRUITING

Berlin, Germany
Royal Adelaide Hospital
RECRUITING

Adelaide, South Australia, 5000, Australia
Royal Melbourne Hospital
RECRUITING

Melbourne, Victoria, 3050, Australia
Sheba Medical Center - Sheba Fund for Health Services and Research
RECRUITING

Ramat Gan, 52621, Israel
Sourasky Medical Center - Infrastructure and Health Services Fund of the Tel Aviv Medical Center
COMPLETED

Tel Aviv, 6423906, Israel
St Vincent's Hospital Melbourne
RECRUITING

Melbourne, Victoria, 3065, Australia
Townsville University Hospital
COMPLETED

Douglas, Queensland, 4814, Australia
Tweed Hospital
RECRUITING

Tweed Heads, New South Wales, 2485, Australia
Universitaetsklinikum Duesseldorf AoeR
COMPLETED

Düsseldorf, Germany
Universitaetsklinikum Leipzig AoeR
COMPLETED

Leipzig, Germany
Universitaetsmedizin Rostock
COMPLETED

Rostock, Germany
Universitaetsmedizin der Johannes Gutenberg-Universitaet Mainz
RECRUITING

Mainz, Germany
University Hospital Bonn
NOT_YET_RECRUITING

Bonn, Germany
University Hospital Geelong
RECRUITING

Geelong, Victoria, 3220, Australia
University Hospital Halle (Saale)
NOT_YET_RECRUITING

Halle, Germany
University of Miami School of Medicine Sylvester Comprehensive Cancer Center (SCCC)
RECRUITING

Miami, Florida, 33136, United States
University of Pittsburgh Medical Health Center
COMPLETED

Pittsburgh, Pennsylvania, 15213, United States
Vseobecna Fakultni Nemocnice Praha
COMPLETED

Prague, Czechia
Westmead Hospital
RECRUITING

Westmead, New South Wales, 2145, Australia

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