Should MDS patients get chemo before a stem cell transplant? new trial aims to find out.

NCT ID NCT06918834

Recruiting now Disease control Sponsor: Institute of Hematology & Blood Diseases Hospital, China Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study compares two strategies for people with higher-risk myelodysplastic syndrome (MDS): getting a donor stem cell transplant right away versus receiving one to two cycles of chemotherapy first (called bridging therapy) before the transplant. The goal is to see if immediate transplant is at least as good as the pre-treatment approach. About 236 adults will take part, and the main outcome is how many are alive and cancer-free two years after transplant.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: allogeneic hematopoietic stem cell transplantation (a donor stem cell transplant) with or without pre-transplant chemotherapy (azacitidine, venetoclax, or targeted drugs)
What this could lead to: If it works, this could show that going straight to transplant is just as effective as pre-treatment, potentially simplifying care and reducing side effects for higher-risk MDS patients.
What could go wrong: This is a Phase 2 trial with 236 participants, so results are still early. The study may not prove one approach is clearly better, and stem cell transplants carry serious risks like infection and graft-versus-host disease.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

myelodysplastic syndrome Myelodysplastic Syndromes

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MYELODYSPLASTIC SYNDROMES

Contacts and locations

Locations

Peking University People's Hospital
RECRUITING

Beijin, Beijing Municipality, 100044, China
People's Liberation Army The General Hospital of Western Theater Command
RECRUITING

Chengdu, Sichuan, 610083, China
The 960th Hospital of the Joint Service Support Force of the Chinese People's Liberation Army
RECRUITING

Jinan, Shandong, China
The Second Hospital of Hebei Medical University
RECRUITING

Shijia Zhuang, China
Zhengzhou University First Affiliated Hospital
RECRUITING

Zhengzhou, Henan, 450000, China

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