Experimental combo aims to boost chemo for tough blood cancers

NCT ID NCT05342584

Recruiting now Disease control Sponsor: Montefiore Medical Center Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This early-phase trial is testing whether adding the targeted drug venetoclax to standard chemotherapy can safely treat adults newly diagnosed with acute myeloid leukemia or advanced myelodysplastic syndrome. About 99 participants will receive different doses of venetoclax alongside chemo drugs daunorubicin and cytarabine. The study's main focus is finding the safest dose and monitoring side effects.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Venetoclax (a targeted drug) combined with standard chemotherapy drugs daunorubicin and cytarabine
What this could lead to: If successful, this could lead to a more effective treatment option for adults with newly diagnosed acute myeloid leukemia or advanced myelodysplastic syndrome.
What could go wrong: This is an early Phase 1 trial, so the main goal is safety, not yet proof of effectiveness. The combination may cause serious side effects, and it is too soon to know if it will improve outcomes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

acute myeloid leukemia myelodysplastic syndrome Myelodysplastic Syndromes

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE MYELOID LEUKEMIA MYELODYSPLASTIC SYNDROMES

Contacts and locations

Locations

Montefiore Einstein Cancer Center and Children's Hospital at Montefiore (CHAM)
RECRUITING

The Bronx, New York, 10467, United States

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