Montefiore Medical Center

This study is testing whether using pilocarpine eye drops after a combined glaucoma and cataract surgery helps control eye pressure better than surgery alone. It involves 142 patients with glaucoma who are having this specific two-in-one procedure. The goal is to see if the drops…

This study is testing a new, lower-dose weekly schedule of two approved drugs (decitabine and venetoclax) for people with certain blood cancers like AML and MDS. The goal is to see if this gentler approach can control the cancer while causing fewer severe side effects and treatme…

This study is collecting and comparing real-world results from thousands of patients who have had a brain aneurysm treated with a special implanted device. The goal is to see which of two main device types—stents that divert blood flow or mesh plugs that fill the aneurysm—works b…

This study is testing a smartphone app designed to help adults with asthma manage their condition. The app analyzes short voice samples to detect early signs of worsening symptoms and connects users with educational resources and community support. Researchers will compare the ap…

This early-stage study is testing the safety and initial effectiveness of adding a new drug, FHD-286, to a standard two-drug treatment for acute myeloid leukemia (AML). It is for adults with newly diagnosed high-risk AML or AML that has come back after one prior treatment. The ma…

This study is testing whether adding the medication dupilumab to standard nasal sprays improves symptoms and sense of smell in patients with chronic sinusitis and nasal polyps. It focuses on including more racial and ethnic minority patients, who are often underrepresented in res…

This study aims to find the best way to prevent infections from a tube (EVD) placed in the brain to drain fluid after a serious brain bleed. Researchers are comparing a single pre-procedure antibiotic dose to a longer course of antibiotics given for the entire time the drain is i…

This early-stage study is testing the safety and best dose of a drug called venetoclax when added to standard chemotherapy for adults newly diagnosed with acute myeloid leukemia (AML) or advanced myelodysplastic syndrome (MDS). The goal is to see if this combination can better co…

This study is looking at the real-world results of a minimally invasive procedure to treat chronic subdural hematoma, a type of brain bleed common in older adults. Researchers will review past medical records of 5,000 patients who had a procedure that blocks a small artery to sto…

This study is testing whether adding a community health worker to a kidney care team helps more patients with advanced kidney disease choose and start dialysis at home. Researchers will compare two groups: one gets standard team care plus a community health worker, and the other …

This study is testing if surgically removing bone tumors before starting chemotherapy leads to better limb function and quality of life for patients. It will follow 10 people with newly diagnosed osteosarcoma in their arms or legs. Researchers will use questionnaires to track how…

This study aims to see if offering enhanced support to fathers in families at risk of substance misuse improves child well-being and family outcomes. It will enroll 240 fathers from the Bronx and nearby areas who have a child under 18 and a family risk of substance use. Participa…

This study is testing if a newer, 'smarter' type of non-invasive breathing support is better for infants with bronchiolitis than the standard method. The newer method uses a special sensor to better match the ventilator's help to the baby's own breathing effort. Researchers want …

This study is testing if a specific type of laser can help treat scarring alopecia, a condition that causes permanent hair loss. Five adults with the condition will receive three laser treatments over three months. Researchers will also collect hair samples to try to understand h…

This study is testing if starting medication for opioid addiction with very small, gradually increasing doses is safe and helps people stick with treatment. It will compare this gentle start to the usual way of beginning treatment in 70 adults with opioid use disorder. Researcher…

This study is testing whether providing free boxes of fresh fruits and vegetables, along with nutrition education, can help people with diabetes or prediabetes better manage their condition. The 6-month program serves 400 participants in the Bronx who struggle with food insecurit…

This study is testing a new, more flexible strategy to help people living with HIV who smoke. Instead of focusing only on quitting completely, it also helps participants reduce smoking, get screened for lung cancer, and manage blood pressure and cholesterol. The goal is to lower …

This global registry aims to understand the safety and effectiveness of a minimally invasive procedure to replace a leaky tricuspid heart valve. It will follow 800 patients who receive the new valve to track complications, recovery, and long-term quality of life. The goal is to i…

This early-stage study is testing the safety and initial effectiveness of a new drug called Danvatirsen, first by itself and then combined with an existing drug, Venetoclax. It is for adults with advanced forms of blood cancer (MDS or AML) that have returned or not responded to a…

This small pilot study is testing if radiation therapy alone can safely treat keloids in people who cannot or choose not to have surgery. Researchers will give a short course of radiation to see if it stops the keloids from growing, shrinks them, and improves quality of life. The…

This study is testing whether sildenafil (the active ingredient in Viagra) can protect blood vessels in people with advanced heart failure who use a mechanical heart pump (LVAD). The goal is to see if the drug can reduce the rapid aging and damage that happens to blood vessels wh…

This study aims to make the standard test for adrenal insufficiency more accurate. Researchers will compare a new, more specific blood test to the current method in 90 participants, including healthy volunteers and patients with known or suspected adrenal insufficiency. The goal …

This study is testing a new type of MRI scan designed to see inside breast tumors in a special way. The scan looks for 'leaky' areas where cancer cells might escape into the bloodstream and spread. Researchers want to see if this scan can help doctors identify which patients have…

This study is testing a new type of talk therapy called Trauma-Focused Psychodynamic Psychotherapy (TFPP) for veterans with PTSD who haven't gotten better with standard treatments. The therapy focuses on understanding trauma experiences without using exposure techniques. Research…

This study compares two pain management approaches for adults recovering from rotator cuff repair surgery. Researchers want to see if a combination of non-narcotic medications works as well as or better than the current standard, which relies more on opioid painkillers. The goal …

This study is testing whether cancer patients will regularly use a mobile app called RestoreMe that provides nutrition education, recipes, exercises, and communication with their care team. The goal is to see if this app can help patients improve their health behaviors and unders…

This study is testing whether a non-psychoactive compound from the cannabis plant, called cannabidivarin (CBDV), can safely reduce irritability and repetitive behaviors in children with autism. It will involve 100 children and teens aged 5 to 18, comparing CBDV to a placebo over …

This study is testing whether a virtual 'Life Story Club' can help reduce feelings of loneliness and apathy in older adults living independently. Researchers will enroll 50 participants aged 60+ to attend weekly online group sessions for 12 weeks, where they share personal storie…

This study is testing a mental health program designed to help teenagers who are having surgery for severe scoliosis. Researchers want to see if teaching coping skills before and after surgery can reduce anxiety, depression, and pain. The program is based on proven therapy techni…

This study is testing if a drug called tranexamic acid (TXA) can reduce bruising and swelling after surgery around the eye socket. 150 patients having this type of surgery will be randomly assigned to receive the drug either by IV, as a local injection, or a standard saline solut…

This study aims to see if a new cold-based nerve treatment works better than the standard heat-based treatment for long-term low back pain. About 110 adults with chronic back pain will be randomly assigned to receive either the cold (iovera) or heat (radiofrequency) procedure. Re…

This study is testing whether the medication duloxetine can help people with low back pain who don't get enough relief from common anti-inflammatory painkillers like naproxen. Researchers are enrolling 120 adults who visit the emergency room with recent back pain to see if duloxe…

This study aims to understand why babies born smaller than average have a higher risk of becoming obese later in life. Researchers will follow 400 mother-baby pairs, collecting blood samples to see if there are lasting chemical changes in the baby's immune cells. The goal is to l…

This study aims to see if a plant-based diet or an animal-based diet has a different effect on erectile function in healthy young men. Researchers will provide meals and use a special home device to measure nighttime erections. The goal is to gather information about how diet mig…

This study aims to understand how certain breast cancer drugs affect body composition—specifically fat and muscle mass. Researchers will follow 30 patients with advanced breast cancer who are starting standard treatment with CDK 4/6 inhibitor drugs. They will use scans and blood …

This study aims to understand how social and economic factors affect medication use and quality of life for Hispanic and Black patients with inflammatory bowel disease (IBD). Researchers will survey 400 adults with Crohn's disease or ulcerative colitis to identify barriers to pro…

This study aims to understand how the knowledge of having an unruptured brain aneurysm affects a person's anxiety and depression. Researchers will compare the mental health of about 120 patients who choose to have their aneurysm treated with those who are monitored over time with…

This study aims to find out which of two common methods for helping patients breathe during a hospital cardiac arrest leads to better survival and recovery. It will compare using a simpler breathing device placed in the throat first versus using the more complex traditional breat…

This study compares two techniques for placing central venous catheters (large IVs) in emergency patients. Researchers want to see if using a small peripheral IV catheter first leads to fewer attempts, fewer complications, and faster placement than the standard needle method. The…

This study compares two artificial intelligence tools to see which one helps doctors make better medical decisions. Twenty-six internal medicine doctors will try solving real patient cases using either OpenEvidence (a medical research tool) or ChatGPT (a general AI assistant). Re…

This study aims to see if a single plant-based meat meal affects overnight erections differently than a single animal meat meal in healthy young men. Researchers will measure erection patterns during sleep using a special device after participants eat each type of meal. The goal …