Montefiore Medical Center

This pilot study tests a 1470nm laser on 10 adults with androgenetic alopecia (common baldness) or scarring alopecia. Researchers will measure hair density and counts using imaging, and track satisfaction. The goal is to see if the laser is safe and can improve hair growth.

This study tests whether DFMO, a drug taken by mouth, can help prevent cancer from coming back in people with relapsed Ewing sarcoma or osteosarcoma who have finished all planned treatment and show no signs of disease. The trial will enroll 15 participants under age 40. The main …

This study tests a program called PRAGMATIC-S that connects doctors' offices with schools to help children ages 4-12 better manage their asthma. The goal is to improve asthma control and quality of life by making sure kids get the right care in both places. About 420 children wit…

This study tests a harm reduction strategy for 400 people with HIV who smoke cigarettes. Instead of pushing for complete quitting, the program helps participants cut down on smoking, get screened for lung cancer, and manage blood pressure and cholesterol. The goal is to improve o…

This study looks at whether adding a community health worker to a kidney care team helps more patients with advanced kidney disease choose or start home dialysis. About 106 adults with severe chronic kidney disease will be split into two groups: one gets standard team care, the o…

This Phase 2 trial is testing whether combining two immunotherapy drugs (cemiplimab and fianlimab) with radiation can shrink tumors in people with locally advanced non-small cell lung cancer who haven't had treatment yet. The study will enroll 76 participants and measure how well…

This early-stage trial is testing a new drug called FHD-286 combined with two standard chemotherapy drugs (decitabine and venetoclax) in 33 people with acute myeloid leukemia that is either newly diagnosed with high-risk features or has returned after one prior treatment. The mai…

This pilot study is testing whether radiation therapy can safely treat keloids (raised scars) when surgery isn't an option or has been refused. Fifteen adults with keloids will receive radiation over several sessions. Researchers will track side effects and measure if the keloids…

This early-phase trial tests whether sildenafil (the drug in Viagra) can reduce blood vessel damage in people with advanced heart failure who have a mechanical heart pump (LVAD). LVADs help patients live longer, but they often cause blood vessel aging that leads to strokes or ble…

This study is testing whether adding dupilumab to standard steroid nasal sprays improves symptoms and sense of smell in people with chronic sinusitis and nasal polyps. It focuses on a diverse, mostly minority group of 60 adults. Participants will receive dupilumab injections and …

This early-phase trial is testing whether adding the targeted drug venetoclax to standard chemotherapy can safely treat adults newly diagnosed with acute myeloid leukemia or advanced myelodysplastic syndrome. About 99 participants will receive different doses of venetoclax alongs…

This study looks back at medical records of 5,000 adults who had a procedure called middle meningeal artery embolization (MMAE) for chronic subdural hematoma, a condition where blood collects on the brain. The goal is to see how well the procedure works, how often the blood comes…

This phase 2 trial tests a low-dose weekly schedule of two drugs, decitabine and venetoclax, in people with myelodysplastic syndromes (MDS), acute myeloid leukemia (AML), or chronic myelomonocytic leukemia (CMML). The goal is to see if this gentler approach reduces treatment dela…

This trial compares two ways to help patients breathe during a cardiac arrest in the hospital: a supraglottic airway (a tube placed in the throat) versus endotracheal intubation (a tube placed into the windpipe). About 1,060 adults who suffer cardiac arrest while hospitalized wil…

This study tests whether adding pilocarpine eye drops after combined cataract and Kahook Dual Blade surgery helps lower eye pressure more than standard drops alone. About 142 adults with glaucoma or high eye pressure will take part. The goal is to see if more patients achieve a 2…

This early-stage study tests a drug called danvatirsen, first by itself and then combined with venetoclax, in 38 adults with relapsed or refractory acute myeloid leukemia (AML) or myelodysplastic syndromes (MDS). The goal is to see if the treatment is safe and can shrink or contr…

This study provides 400 adults with diabetes or prediabetes who struggle to afford food with free fresh food boxes and nutrition classes twice a month for six months. Researchers will check if this program helps lower blood sugar levels and reduces food insecurity. The goal is to…

This study tests a low-dose method of starting buprenorphine-naloxone for opioid use disorder, compared to standard guidelines. The goal is to see if this approach is safe, effective, and acceptable to patients. The trial enrolls 70 adults with opioid use disorder who are willing…

This study aims to find the most accurate cortisol levels to diagnose adrenal insufficiency, a condition where the body doesn't make enough cortisol. Researchers will test 90 healthy volunteers and people already diagnosed with the condition using a new, highly specific cortisol …

This study tests a special MRI technique called TMEM-MRI that looks at the tumor environment to see how likely breast cancer is to spread. About 95 women with operable breast cancer will get this MRI before their standard biopsy or surgery. The goal is to see if this imaging meth…

This study tests whether desloratadine, a common allergy medication, can prevent nerve damage caused by taxane chemotherapy in breast cancer patients. About 116 participants will receive either desloratadine or a placebo for 12 weeks while on chemotherapy. The goal is to see if t…

This study compares two treatments for chronic low back pain: one uses cold (cryoneurolysis) to numb nerves, the other uses heat (radiofrequency ablation). About 110 adults with long-term back pain will be randomly assigned to one of the two groups. Researchers will track pain le…

This study is testing a type of talk therapy for people who have both HIV and PTSD. The therapy helps people understand how trauma affects their emotions and relationships. The goal is to see if this therapy is helpful and acceptable for this group. About 20 adults with HIV and P…

This pilot study is testing whether a one-time, 45-minute virtual reality (VR) session guided by an AI coach can help people with chronic pain who also misuse opioids. The session includes a check-in, pain coping skills training, and a stress reduction exercise. The study involve…

This study compares a newer anti-nausea drug, fosaprepitant, to the standard medicine ondansetron for adults coming to the emergency room with nausea and vomiting. The goal is to see if fosaprepitant provides faster relief without needing extra medication. About 200 participants …

This study tests a minimally invasive procedure called TENEX for people with chronic hip pain from Greater Trochanteric Pain Syndrome (GTPS). The procedure uses ultrasound guidance to partially release tight tendons around the hip. Researchers will compare pain levels and quality…

This study tests DaxibotulinumtoxinA (Daxxify) in 40 adults with benign essential blepharospasm (uncontrollable eye blinking) or hemifacial spasm (one-sided face twitching). Participants who previously used Botox will switch to Daxxify to see if it works as well or better. The ma…

This study compares three types of spacer grafts (hard palate, ear cartilage, and a porcine product) used in surgery to fix lower eyelid retraction, a condition where the eyelid pulls down. Researchers will measure eyelid height and track complications in 100 adults who had this …

This study looks at whether adding a short course of dexamethasone (a steroid) to standard ibuprofen treatment can improve pain and disability in people with acute radicular low back pain (pain that shoots from the back down the leg). About 132 adults visiting the emergency depar…

This study tests whether a short course of cognitive behavioral therapy (CBT) can reduce anxiety and pain in teenagers recovering from scoliosis surgery. About 45 teens aged 10–19 will receive either standard care or CBT sessions (plus a mobile app) before and after their operati…

This study compares how a single plant-based meat meal (a Beyond Meat product) versus an animal meat meal affects erectile function in 30 healthy men with normal erections. Participants eat one meal and then wear a Rigiscan device overnight to measure erection hardness and freque…

This study looks at which pain control method works best after rotator cuff repair surgery. Researchers will compare different combinations of pain medicines to see which reduces the need for strong narcotics like oxycodone. About 130 adults having shoulder surgery will take part…

This study tests whether a virtual group reminiscence program called Life Story Club can reduce loneliness and apathy in adults aged 60 and older. Fifty participants will meet weekly over Zoom for 12 weeks to share personal stories. Researchers will measure changes in loneliness,…

This study is testing whether a special non-ablative laser can help treat scarring alopecia, a condition that causes permanent hair loss. Five adults will receive three laser treatments and attend follow-up visits over 15 months. Researchers will also study hair follicle genes to…

This study tests whether tranexamic acid (TXA), a drug that helps blood clot, can reduce swelling and bruising after eye socket surgery. About 150 adults having orbital surgery will receive TXA locally, systemically, or a placebo. The goal is to see if TXA leads to less swelling …

This study tests whether duloxetine, a medication often used for depression, can reduce low back pain in people who didn't get better with NSAIDs like naproxen. About 120 adults from the emergency department will take either duloxetine or a placebo for two weeks. The goal is to s…

This study tests a type of talk therapy called Trauma-Focused Psychodynamic Psychotherapy (TFPP) for veterans with PTSD who haven't gotten better with standard VA treatments. About 75 veterans will be randomly assigned to receive either TFPP or usual care. The goal is to see if T…

This study is testing a mobile app called ASTHMAXcel Voice to see if it helps adults with asthma better control their symptoms. The app sends reminders and educational content to users. Two hundred adults with persistent asthma will either use the app or receive usual care, and r…

This Phase 2 trial tests whether cannabidivarin (CBDV), a compound from cannabis, can reduce irritability and repetitive behaviors in children with autism spectrum disorder. About 100 children aged 5 to 18 will receive either CBDV or a placebo daily for several weeks. Researchers…

This study compares two types of non-invasive breathing support for infants under 2 years old with bronchiolitis in the pediatric ICU. One method uses standard ventilation, while the other uses a smarter mode called NAVA that synchronizes with the baby's own breathing. The goal i…

This study tests a program called SPARK-CGM that helps primary care clinics prescribe continuous glucose monitors (CGM) to people with diabetes. CGM devices track blood sugar in real-time, but they are underused in primary care. The program provides training, workflow support, an…

This study recruits 500 people who inject drugs through social media to see if they can use at-home HIV test kits mailed to them. Participants fill out online surveys and mail back samples. The goal is to find out if this approach is a practical way to conduct HIV prevention rese…

This study tests a tool called DOTS that helps doctors create a personalized plan to reduce opioid painkillers after orthopedic surgery. The tool is built into the hospital's computer system and includes a taper schedule, a patient handout, and phone support after discharge. Rese…

This study looks at the genetic makeup of head and neck tumors from 1,000 people to find markers that predict how well a patient will respond to treatment and their chances of survival. Researchers will also search for new diagnostic markers. The goal is to better understand why …

This study looks at whether special programs for fathers can help families in the Bronx and nearby areas who are at risk for substance misuse. About 240 fathers will be randomly assigned to either get usual services or extra support like counseling, fatherhood classes, and case m…

This pilot study looks at 10 people with a new, high-grade bone cancer (osteosarcoma) in an arm or leg. The goal is to see if removing the tumor with surgery before starting chemotherapy leads to better arm or leg function and quality of life. Participants and their surgeons will…

This study is testing whether cancer patients will regularly use a mobile app called RestoreMe to help with diet, nutrition, and activity during their treatment. About 50 patients with various cancers (like breast, lung, or prostate) who are getting radiation therapy will be aske…

This study looks at whether giving antibiotics for just 24 hours around the time of placing a special antibiotic-coated brain drain works as well as giving them for the whole time the drain is in place. The goal is to find the best way to prevent serious brain infections in peopl…

This study surveys 400 adults with inflammatory bowel disease (IBD) from two medical centers to understand how social factors like insurance, income, and support affect medication adherence and quality of life. Researchers focus on Hispanic and Black patients, who often have wors…

This study looks back at medical records of up to 5,000 adults who had a brain aneurysm treated with special mesh tubes called flow diverters. Researchers want to see how well these devices work and how safe they are by checking things like successful placement, complications, an…

This study compares two techniques for inserting a central venous catheter in adult emergency department patients with shock. Researchers want to see which method leads to higher first-attempt success, fewer complications, and faster completion. 160 participants will be randomly …

This study looks at how knowing you have an unruptured brain aneurysm affects your mental health, and whether getting it treated or just monitoring it makes a difference. Researchers will follow 120 people with unruptured aneurysms, comparing those who have surgery or a less inva…

This study looks at how plant-based meals compare to animal-based meals on erectile function in 46 healthy men with normal erections. Participants eat specially prepared meals and wear a device to measure nighttime erections. The goal is to see if diet alone can make a difference…

This study looks at why babies born with restricted growth (IUGR) have a higher risk of childhood obesity. Researchers will track 400 mother-infant pairs for two years, analyzing T-cell changes and DNA methylation. The goal is to uncover early biological signs that could lead to …

This global registry will follow 800 patients receiving a new, less-invasive tricuspid valve replacement (TTVR) for leaky heart valves. Researchers aim to track complications like pacemaker needs and how well the valve works over time. The study does not test a new drug but gathe…