Could a Low-Dose start make opioid treatment easier?
NCT ID NCT05450718
First seen Jun 25, 2026 · Last updated Jun 26, 2026 · Updated 1 time
Summary
This study tests a low-dose method of starting buprenorphine-naloxone for opioid use disorder, compared to standard guidelines. The goal is to see if this approach is safe, effective, and acceptable to patients. The trial enrolls 70 adults with opioid use disorder who are willing to follow the assigned regimen.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
buprenorphine-naloxone (low-dose initiation)
What this could lead to
If successful, this could make starting buprenorphine treatment easier and more comfortable for people with opioid use disorder, potentially increasing treatment uptake.
What could go wrong
This is a small pilot study with only 70 participants, focused on feasibility. It may not prove effectiveness, and low-dose initiation might not work for everyone or could have side effects.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Montefiore Medical Center
RECRUITINGThe Bronx, New York, 10467, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-••••