Montefiore Medical Center

This study tested whether giving buprenorphine treatment in group medical visits (instead of one-on-one) helps people with opioid use disorder stay abstinent and remain in treatment. Eighteen adults already on buprenorphine but still using opioids took part in weekly 90-minute gr…

This phase 2 trial tested a combination of FLT3 ligand immunotherapy (CDX-301) and stereotactic body radiotherapy (SBRT) in 33 adults with advanced non-small cell lung cancer that had worsened after standard treatments. The goal was to see if this approach could slow cancer growt…

This pilot study tested a precise type of radiation called stereotactic body radiation therapy (SBRT) in 20 adults with liver cancer that could not be surgically removed. The goal was to see if the treatment is safe and to measure how long patients survive. The approach aims to d…

This early-phase trial tested a new type of radiation called carbon ion therapy for people with locally advanced pancreatic cancer that cannot be removed by surgery. Fourteen participants received increasing doses of carbon ion radiation along with chemotherapy. The main goal was…

This study tested whether tracking daily steps with a simple pedometer could help identify cancer patients at high risk of being hospitalized during chemoradiotherapy. 40 adults with head and neck, lung, esophageal, or stomach cancer wore a pedometer and received extra support li…

This study tested a school-based program called Asthma-PASS to help children with asthma be more physically active. The program worked with doctors, community health workers, and schools to ensure kids had the right medications and could use rescue inhalers at school. Researchers…

This phase 2 trial tested a combination of the immunotherapy drug pembrolizumab and a personalized 4-week course of radiotherapy in 25 patients with advanced non-small cell lung cancer whose tumors had high PD-L1 levels. The goal was to see if this approach could control the canc…

This study looked at whether men with advanced prostate cancer could safely stop their regular hormone injections (like leuprolide) and rely only on the pills abiraterone and prednisone to keep testosterone at very low levels. 31 men participated. The goal was to see if testoster…

This pilot study tested whether a multicultural anti-inflammatory diet is practical and acceptable for racial/ethnic minorities with chronic kidney disease (CKD). Researchers enrolled 18 adults with stage 3 CKD in the Bronx, providing dietary counseling tailored to each person's …

This study looked at whether giving buprenorphine treatment directly at syringe exchange programs helps people with opioid addiction more than sending them to a community health center. About 100 syringe exchange participants in New York City took part. The goal was to see if sta…

This study tested a computer-based program that reminds doctors to follow asthma guidelines for children aged 2 to 12 with persistent or uncontrolled asthma. The program helped doctors take more corrective actions, like adjusting medication or checking triggers. The goal was to r…

This study tested whether a special group therapy program called Positively Smoke Free helps people living with HIV quit smoking better than standard care. 450 HIV-positive smokers who wanted to quit took part. The main goal was to see if more people stayed smoke-free for 6 month…

This study looked at how the drug emicizumab (Hemlibra) works in real-world settings for infants and children up to 3 years old with hemophilia A, a bleeding disorder. Researchers tracked 71 children to see how many were using emicizumab to prevent bleeds and whether any breakthr…

This study tested two common pain relievers for sudden low back pain: a topical gel (diclofenac) and oral pills (ibuprofen). 198 adults from the emergency department were randomly assigned to receive one or both treatments. Researchers measured how much pain affected daily activi…

This study looked at whether adding a steroid called dexamethasone to standard headache medicine helps people with headaches caused by a recent head injury. 162 adults with moderate to severe headaches were randomly assigned to get either the steroid plus standard medicine or sta…

This study tested whether a simple walking program, guided by a fitness tracker, could help cancer patients tolerate their chemoradiotherapy without missing treatments. 166 adults with brain, head and neck, lung, gastrointestinal, or cervical cancer participated. Patients were gi…

This study looked at whether people with chronic pain and opioid use disorder would do art on their own at home, and if it helped their pain and mood. 31 adults tried self-directed artmaking up to four times. Researchers measured how many people stuck with it and whether anxiety,…

This study tested whether virtual reality goggles can reduce pain and anxiety during blood draws in hospitalized children aged 5 to 21. Half of the 126 participants received standard care (including numbing cream), while the other half also wore VR goggles before and during the p…

This study tested whether silicone gel helps reduce scarring after eyelid surgery. 132 patients applied silicone gel to one eye and a placebo (Aquaphor) to the other, without knowing which was which. Doctors and patients rated scar redness, elevation, and pigmentation over 6 mont…

This study tested whether taking melatonin for three nights before wisdom tooth surgery could lower pain and the need for pain medication afterward. Sixty adults aged 18-35 took either melatonin or a placebo before their surgery. Researchers measured how many pain pills they used…

This study tested whether a special nerve block (erector spinae plane block) could help control pain and reduce the need for strong painkillers after breast reduction surgery. 78 adults took part. The goal was to see if adding this block to standard pain management leads to using…

This study tested whether practicing mindfulness meditation using the Headspace app before a minimally invasive hysterectomy could lower pain and stress after surgery. Seventy-two women were randomly assigned to either meditate regularly before surgery or receive standard care. R…

This study tested whether a 12-session parenting group therapy, called the Connecting and Reflecting Experience (CARE) program, is helpful and doable for new parents struggling with postpartum depression or anxiety. Seventeen parents of babies aged 3 to 12 months took part. The g…

This study looked at whether medical cannabis can reduce nerve pain and inflammation in people with HIV. Thirty-five adults with HIV and neuropathic pain used different ratios of THC and CBD over 14 weeks. Researchers measured changes in pain severity and blood markers of inflamm…

This study tested whether community health workers with lived experience of incarceration could help people recently released from jail or prison get COVID-19 tests and adopt safety measures like mask-wearing and social distancing. The program included education, on-site testing,…

This study tested whether people with diabetes would use a special foot mat at home every day. The mat, called the Podimetrics SmartMat, measures foot temperature to spot early signs of foot ulcers. Twenty people who had a foot ulcer in the past used the mat for six months. The m…

This completed trial tested a virtual version of the Supporting Healthy Relationships program for 1,022 low-income couples with children in the Bronx. The program included 24 hours of workshops on relationship skills, parenting, and financial support. Researchers measured changes…

This pilot study looked at whether cancer patients with head and neck, lung, or digestive system cancers could wear a fitness tracker during radiation therapy. The goal was to see if tracking activity levels and quality of life is practical and might relate to treatment outcomes.…

This study tested two AI tools—OpenEvidence and GPT-4 (ChatGPT)—to see which one helps doctors make better diagnoses and treatment decisions. Twenty-seven internal medicine doctors used both tools on medical cases. The goal was to compare how accurate and fast each AI made them. …

This study tested a training program to help doctors reduce racial bias when talking to families of seriously ill patients. Twenty-two doctors participated in simulated conversations with a Black actor playing a family member. The goal was to see if bias training improved communi…

This study tested a program called HERO Dads, a 4-week series of workshops for low-income non-custodial fathers in the Bronx. The workshops aimed to improve parenting skills, relationships, anger management, and job readiness. A total of 496 fathers took part, and researchers mea…

This completed study looked at how well the HPV vaccine protects against HPV infections over time in over 3,000 Rwandan women aged 18-28, some living with HIV and some without. Researchers collected blood, oral, and other samples to measure vaccine effectiveness and long-term ant…

This completed study followed 126 babies born at 35 weeks or later who were at risk for low blood sugar (hypoglycemia). Researchers compared those who had low blood sugar in their first day of life with those who did not, testing their thinking, movement, and language skills at 1…

This pilot study tested whether adding ergonomics training to the surgical curriculum helps OB/GYN residents learn safer body movements to prevent work-related injuries. 23 residents took a class on ergonomics and then practiced surgical skills on a model. Half received personali…