Worldwide registry aims to unlock secrets of tricuspid valve replacement

NCT ID NCT06033274

Recruiting now Knowledge-focused Sponsor: Montefiore Medical Center Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This global registry will follow 800 patients receiving a new, less-invasive tricuspid valve replacement (TTVR) for leaky heart valves. Researchers aim to track complications like pacemaker needs and how well the valve works over time. The study does not test a new drug but gathers real-world data to guide future care.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Transcatheter Tricuspid Valve Replacement (a device procedure to replace the tricuspid valve without open-heart surgery)
What this could lead to: If successful, this registry could provide crucial data to improve the safety and effectiveness of a less invasive valve replacement for people with severe tricuspid regurgitation.
What could go wrong: This is an observational registry, not a controlled trial, so it cannot prove cause and effect. Results may be limited by differences in patient care across centers.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

heart valve disorder tricuspid valve insufficiency

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

TRICUSPID REGURGITATION

Contacts and locations

Locations

Arizona Heart Hospital (Biltmore Cardiology)
RECRUITING

Phoenix, Arizona, 85016, United States
Cardiovascular Center (CVC) Frankfurt, Division of Cardiology
RECRUITING

Frankfurt, 60389, Germany
Centre Hospitalier Universitaire de Lille
RECRUITING

Lille, 59000, France
Centro Cardiologico Monzino IRCCS
RECRUITING

Milan, 20138, Italy
Chu De Bordeaux - Haut-Lévêque Hospital
RECRUITING

Bordeaux, Pessac, 33600, France
Cleveland Clinic
RECRUITING

Cleveland, Ohio, 44195, United States
Clinique Pasteur Toulouse
RECRUITING

Toulouse, 31300, France
Columbia University Irving Medical Center
RECRUITING

New York, New York, 10032, United States
Heart Center Cologne, University of Cologne
RECRUITING

Cologne, 50924, Germany
Heart and Diabetes Centre, North Rhine-Westphalia (NRW), Ruhr-University
RECRUITING

Bad Oeynhausen, 32545, Germany
Medical Clinic and Polyclinic, University Hospital of Munich (LMU Klinikum)
RECRUITING

Munich, 80333, Germany
Montefiore Medical Center
RECRUITING

The Bronx, New York, 10461, United States
Oregon Health & Science University
ENROLLING_BY_INVITATION

Portland, Oregon, 97239, United States
Quebec Heart and Lung Institute, Laval University, Quebec City, Quebec, Canada
RECRUITING

Québec, Quebec, G1V 4G5, Canada
Rigshospitalet, Copenhagen University Hospital
RECRUITING

Copenhagen, 2100, Denmark
San Raffaele University Hospital
RECRUITING

Milan, 20132, Italy
St Michael's Hospital, University of Toronto
RECRUITING

Toronto, Ontario, M5B 1W8, Canada
St. Paul's Hospital
RECRUITING

Vancouver, British Columbia, V6Z 1Y6, Canada
University Heart Center, Schleswig-Holstein University
RECRUITING

Lübeck, D-23538, Germany
University Heart and Vascular Center, Department of Cardiology
RECRUITING

Hamburg, 20251, Germany
University Hospital Alvaro Cunqueiro (CHUVI)
RECRUITING

Vigo, Pontevedra, 36312, Spain

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