Study aims to find best treatment for leaky heart valve in older adults

NCT ID NCT05825898

ENROLLING_BY_INVITATION Disease control Sponsor: Ottawa Heart Institute Research Corporation Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at 3,500 people with severe tricuspid regurgitation, a common heart valve problem in older adults. It compares medical therapy (diuretics), surgery, and a less invasive transcatheter procedure to see which works best and when to treat. The goal is to improve survival and reduce heart failure hospitalizations.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Surgery or transcatheter tricuspid valve intervention
What this could lead to: If successful, this could help doctors choose the best treatment and timing for patients with severe tricuspid regurgitation, potentially improving survival and reducing hospital visits.
What could go wrong: This is an observational study, not a randomized trial, so results may be influenced by patient differences. Surgery carries a high risk of in-hospital death (about 10%), and the study is still enrolling.

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Conditions

The condition(s) this trial relates to.

tricuspid valve insufficiency

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

TRICUSPID REGURGITATION

Contacts and locations

Locations

APHM, La Timone Hospital, Cardiology Department

Marseille, France
Albertinen Heart and Vascular Center

Hamburg, Germany
Amiens University Hospital

Amiens, France
Asklepios clinic Sankt Georg

Hamburg, Germany
Bonn University Hospital

Bonn, Germany
CHU Charles Nicolle

Rouen, France
CHU Lille

Lille, France
CHU de Nantes

Nantes, France
CHU de RENNES

Rennes, France
Cardiology Department, Centre Cardiologique du Nord

Saint-Denis, France
Cardiovascular center Frankfurt

Frankfurt, Germany
Charité Universitätsmedizin Berlin

Berlin, Germany
Columbia University Medical Center

New York, New York, 10032, United States
Department of Cardiology, Bichat Claude Bernard Hospital

Paris, France
Department of Cardiology, University Hospital of Nancy-Brabois

Nancy, France
Department of Cardiovascular Surgery and Transplantation, Louis Pradel Cardiovascular Hospital

Lyon, France
Henri Mondor Hospital

Créteil, France
Herz- und Diabeteszentrum

Bad Oeynhausen, Germany
Hopital Universitaire de Bern

Bern, Switzerland
Hospital 12 de Octubre

Madrid, Spain
Hospital Clínico San Carlos

Madrid, Spain
Hospital Gregorio Marañón

Madrid, Spain
Hospital Ramón y Cajal

Madrid, Spain
IUCPQ

Québec, Canada
Instituto Auxologico Italiano, IRCCS

Milan, Italy
Istituto Cardiocentro Ticino

Lugano, Switzerland
Leiden University Medical center

Leiden, Netherlands
Leipzig University Hospital

Leipzig, Germany
Mayo Clinic Rochester

Rochester, Minnesota, 55905, United States
Montefiore Health System

New York, New York, 10467, United States
Mount Sinai

New York, New York, 10029, United States
Munich Großhadern

Munich, Germany
Puerta de Hierro

Madrid, Spain
Rangueil University Hospital

Toulouse, France
San Raffaele University Hospital

Milan, Italy
St Michael's Hospital

Toronto, Canada
St Paul Hospital

Vancouver, Canada
Tel Aviv Medical center

Tel Aviv, Israel
University Heart and Vascular Center

Hamburg, Germany
University Medical Center of Mainz

Mainz, Germany
University of Cologne

Cologne, Germany
University of Ottawa Heart Institute

Ottawa, Ontario, K1Y 4W7, Canada
Vienna Medical University

Vienna, Austria
Zurich Heart Center

Zurich, Switzerland

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