Could an antidepressant ease stubborn back pain?
NCT ID NCT05851976
First seen Dec 02, 2025 · Last updated Jun 22, 2026 · Updated 25 times
Summary
This study tests whether duloxetine, a medication often used for depression, can reduce low back pain in people who didn't get better with NSAIDs like naproxen. About 120 adults from the emergency department will take either duloxetine or a placebo for two weeks. The goal is to see if duloxetine helps prevent ongoing pain three months later.
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Montefiore Medical Center
RECRUITINGThe Bronx, New York, 10467, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Duloxetine
What this could lead to
If it works, this could offer a new option for people with low back pain who don't get relief from common anti-inflammatory drugs.
What could go wrong
This is a small, early-phase exploratory study, so results may not apply widely. Duloxetine can cause side effects like nausea or dizziness, and it may not help everyone.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.