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New drug combo takes on Hard-to-Treat bone marrow cancer

NCT ID NCT04245397

Recruiting now Disease control Sponsor: Syntrix Biosystems, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early-stage trial is testing a new oral drug called SX-682, alone or with the chemotherapy drug decitabine, in people with myelodysplastic syndrome (MDS) — a bone marrow disorder. The main goal is to find a safe dose and check for side effects. About 151 adults whose MDS has not responded to standard treatments will take part. The study is currently recruiting.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
SX-682 (an oral drug that blocks certain immune signals) and decitabine (a chemotherapy-like drug)
What this could lead to
If it works, this could point toward a new treatment option for people with myelodysplastic syndrome who have not responded to standard therapies.
What could go wrong
This is an early Phase 1 trial with only 151 participants, focused on safety and dosing. It is too small and early to know if the drug will be effective or have manageable side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

myelodysplastic syndrome Myelodysplastic Syndromes

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MYELODYSPLASTIC SYNDROMES

Contacts and locations

Locations

  • AdventHealth Medical Group & Bone Marrow Transplant at Orlando

    RECRUITING

    Orlando, Florida, 32804, United States

  • Emory University

    RECRUITING

    Atlanta, Georgia, 30322, United States

  • Mayo Clinic

    RECRUITING

    Jacksonville, Florida, 32224, United States

  • Moffitt Cancer Center

    RECRUITING

    Tampa, Florida, 33612, United States

  • Montefiore Medical Center

    RECRUITING

    The Bronx, New York, 10467, United States

    Contact Email: •••••@•••••

  • Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

    RECRUITING

    Baltimore, Maryland, 21287, United States

  • University of Miami

    RECRUITING

    Miami, Florida, 33136, United States

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