New hope for Hard-to-Treat leukemia? enzomenib trial launches

NCT ID NCT04988555

Recruiting now Disease control Sponsor: Sumitomo Pharma America, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a new oral drug called enzomenib (DSP-5336) in people with acute leukemia and certain other blood cancers that have not responded to standard treatments. The trial has two phases: first, finding the safest dose, and then checking how well it works alone or combined with other drugs. About 606 participants will be enrolled across multiple sites.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Enzomenib (DSP-5336)
What this could lead to: If successful, this could lead to a new targeted treatment option for certain types of acute leukemia that have not responded to standard therapies.
What could go wrong: This is an early-phase trial (phase 1/2) with a small number of participants, so safety and effectiveness are not yet proven. Side effects are unknown, and the drug may not work for all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

acute leukemia of ambiguous lineage acute lymphoblastic leukemia acute myeloid leukemia myelodysplastic syndrome Myelodysplastic Syndromes plasma cell myeloma Precursor Cell Lymphoblastic Leukemia-Lymphoma Recurrence

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LEUKEMIA, LYMPHOCYTIC, ACUTE LEUKEMIA, MYELOID, ACUTE MULTIPLE MYELOMA MYELODYSPLASTIC SYNDROMES

Contacts and locations

Locations

AZ Delta
RECRUITING

Roeselare, Belgium
Allegheny Health Network
RECRUITING

Pittsburgh, Pennsylvania, 15224, United States
Atlantic Health
RECRUITING

Morristown, New Jersey, 07960, United States
Atrium Wake Forest Baptist Medical Center
RECRUITING

Winston-Salem, North Carolina, 27157, United States
Azienda USL della Romagna, Ospedale Santa Maria delle Croci di Ravenna
NOT_YET_RECRUITING

Ravenna, 48121, Italy
Bristol Hematology & Oncology Centre
RECRUITING

Bristol, United Kingdom
CHU Bordeaux
NOT_YET_RECRUITING

Talence, 33000, France
CHU de Nantes
NOT_YET_RECRUITING

Nantes, 44093, France
CHU de Nice - Hôpital l'Archet 1
RECRUITING

Nice, France
Centre Hospitalier Le Mans
RECRUITING

Le Mans, France
Centre Hospitalier Universitaire d'Angers
RECRUITING

Angers, France
Centre Hospitalier Universitaire de Limoges
RECRUITING

Limoges, France
Chonnam National University Hwasun Hospital
RECRUITING

Hwasun, South Korea
Christie Hospital NHS Foundation Trust
RECRUITING

Manchester, United Kingdom
Churchill Hospital Oxford
NOT_YET_RECRUITING

Oxford, United Kingdom
Colorado Blood Cancer Institute
RECRUITING

Denver, Colorado, 80218, United States
Columbia University
COMPLETED

New York, New York, 10032, United States
Complexo Hospitalario Universitario De Santiago
RECRUITING

Santiago de Compostela, Spain
Duke University
RECRUITING

Durham, North Carolina, 27705, United States
Fukushima Medical University Hospital
RECRUITING

Fukushima, Fukushima, 960-1295, Japan
Fundacion Instituto de Investigacion Marques de Valdecilla
RECRUITING

Santander, Spain
Georgetown Lombardi Comprehensive Cancer Center
NOT_YET_RECRUITING

Washington D.C., District of Columbia, 20007, United States
Hoag Family Cancer Center
RECRUITING

Newport Beach, California, 92663, United States
Hokkaido University Hospital
NOT_YET_RECRUITING

Hokkaido, 060-8648, Japan
Hopital Avicenne
NOT_YET_RECRUITING

Bobigny, 93000, France
Hopital Claude Huriez
NOT_YET_RECRUITING

Lille, 59037, France
Hopital Saint-Louis
RECRUITING

Paris, France
Hospices Civils de Lyon
RECRUITING

Lyon, France
Hospital General Universitario De Albacete
RECRUITING

Albacete, Spain
Hospital San Pedro de Alcantara
RECRUITING

Cáceres, Spain
Hospital Universitari Vall D'Hebron
RECRUITING

Barcelona, Spain
Hospital Universitario Central De Asturias
RECRUITING

Oviedo, Spain
Hospital Universitario De Gran Canaria Dr. Negrin
RECRUITING

Las Palmas, Spain
Hospital Universitario de Salamanca
RECRUITING

Salamanca, Spain
Hospital Universitario y Politecnico La Fe
RECRUITING

Valencia, Spain
Huntsman Cancer Institute
RECRUITING

Salt Lake City, Utah, 84112, United States
IRCCS Azienda Ospedaliero-Universitaria Di Bologna, Policlinico Sant'Orsola
RECRUITING

Bologna, Italy
IRCCS istituto Romagnolo per lo studio dei tumori "Dino Amadori"
RECRUITING

Meldola, Italy
Institut Catala d'Oncologia
RECRUITING

Barcelona, Spain
Institut Gustave Roussy
NOT_YET_RECRUITING

Villejuif, 94800, France
Institut Paoli-Calmettes
RECRUITING

Marseille, France
Intermountain Healthcare
RECRUITING

Salt Lake City, Utah, 84143, United States
Istituto Oncologico Veneto (IOV), IRCCS
NOT_YET_RECRUITING

Padua, Italy
Johns Hopkins Main Center
RECRUITING

Baltimore, Maryland, 21287, United States
King's College Hospital
RECRUITING

London, United Kingdom
Kyushu University Hospital
RECRUITING

Fukuoka, 812-8582, Japan
MD Anderson Cancer Center
RECRUITING

Madrid, Spain
MDACC
RECRUITING

Houston, Texas, 77030, United States
Massachusetts General Hospital
RECRUITING

Boston, Massachusetts, 02114, United States
Medical University of South Carolina
RECRUITING

Charleston, South Carolina, 29425, United States
Miami Cancer Institute
NOT_YET_RECRUITING

Miami, Florida, 33176, United States
Moffitt Cancer Center
NOT_YET_RECRUITING

Tampa, Florida, 33612, United States
Mount Sinai Hospital
COMPLETED

New York, New York, 10029, United States
NHS Lothian Western General
NOT_YET_RECRUITING

Edinburgh, EH4 2XU, United Kingdom
Nagasaki University Hospital
RECRUITING

Nagasaki, Nagasaki, 852-8501, Japan
National Cancer Center Hospital East
RECRUITING

Kashiwa-shi, Chiba, 277-8577, Japan
National Cheng Kung University Hospital
RECRUITING

Tainan, Taiwan
National Taiwan University Hospital
RECRUITING

Taipei, Taiwan
National University Cancer Institute
RECRUITING

Singapore, 119074, Singapore
Nippon Medical School Hospital
RECRUITING

Bunkyo-ku, Tokyo, 113-8603, Japan
Northwestern
RECRUITING

Chicago, Illinois, 60611, United States
Okayama University Hospital
RECRUITING

Okayama, 700-8558, Japan
Oncology Associates of Oregon
RECRUITING

Eugene, Oregon, 97401, United States
Osaka University Hospital
RECRUITING

Osaka, 565-0871, Japan
Ospedale Policlinico San Martino, IRCCS
RECRUITING

Genoa, Italy
Ospedale di Busto Arsizio
NOT_YET_RECRUITING

Busto Arsizio, 21052, Italy
PU A. Gemelli, Università Cattolica del Sacro Cuore
RECRUITING

Rome, Italy
Roswell Park Comprehensive Cancer Center
RECRUITING

Buffalo, New York, 14203, United States
Rutgers Cancer Institute of New Jersey
RECRUITING

New Brunswick, New Jersey, 08901, United States
Samsung Medical Center
RECRUITING

Seoul, South Korea
Sarah Cannon Research Institute
NOT_YET_RECRUITING

London, United Kingdom
Seoul National University Hospital
RECRUITING

Seoul, South Korea
Sibley Memorial Hospital
RECRUITING

Baltimore, Maryland, 20016, United States
Sidney Kimmel Comprehensive Cancer Center
RECRUITING

Philadelphia, Pennsylvania, 19107, United States
Stanford University
NOT_YET_RECRUITING

Palo Alto, California, 94304, United States
Taichung Veterans General Hospital
RECRUITING

Taichung, Taiwan
The Catholic University of Korea
RECRUITING

Seoul, South Korea
The Ohio State University Comprehensive Cancer Center
RECRUITING

Columbus, Ohio, 43210, United States
The Royal Marsden NHS Foundation Trust
RECRUITING

Sutton, United Kingdom
Tohoku University Hospital
RECRUITING

Miyagi, 980-8574, Japan
Tokai University Hospital
RECRUITING

Isehara-shi, Kanagawa, 259-1193, Japan
Tokyo Metropolitan Komagome Hospital
NOT_YET_RECRUITING

Bunkyō City, 113-8677, Japan
Tom Baker Cancer Center
RECRUITING

Calgary, Alberta, T2N 5G2, Canada
TriStar Centennial Medical Center
RECRUITING

Nashville, Tennessee, 37203, United States
Tufts University
WITHDRAWN

Boston, Massachusetts, 02111, United States
UNC Hospital
RECRUITING

Chapel Hill, North Carolina, 27514, United States
UZ Ghent
RECRUITING

Ghent, 9000, Belgium
Universita' Degli Studi Di Torino
RECRUITING

Turin, Italy
Universitaetsspital Zuerich - Haematology
NOT_YET_RECRUITING

Zurich, 8091, Switzerland
University College London Hospitals NHS Foundation Trust
RECRUITING

London, United Kingdom
University Hospital Basel
NOT_YET_RECRUITING

Basel, 4031, Switzerland
University Hospital Bern Inselspital
NOT_YET_RECRUITING

Bern, 3010, Switzerland
University Hospitals Leuven
RECRUITING

Leuven, Belgium
University Hospitals of Birmingham Centre for Clinical Hematology
RECRUITING

Birmingham, United Kingdom
University Hospitals of North Midlands NHS Foundation Trust
NOT_YET_RECRUITING

Stoke-on-Trent, United Kingdom
University of Alberta
RECRUITING

Edmonton, T6G 2R3, Canada
University of Fukui Hospital
RECRUITING

Yoshida-gun, Fukui, 910-1193, Japan
University of Maryland
RECRUITING

Baltimore, Maryland, 21201, United States
University of Miami
RECRUITING

Miami, Florida, 33136, United States
University of Virginia
RECRUITING

Charlottesville, Virginia, 22908, United States
Università degli Studi di Perugia
RECRUITING

Perugia, Italy
Virginia Cancer Specialists
RECRUITING

Fairfax, Virginia, 22031, United States
Virginia Oncology Associates
RECRUITING

Norfolk, Virginia, 23502, United States
ZNA Cadix
RECRUITING

Antwerp, Belgium

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