Ohsu Knight Cancer Institute

This study offers a special bone marrow transplant for people with cancer or other serious diseases who lack a perfectly matched donor. Doctors use a device to select only the stem cells from a partially matched donor, removing immune cells that could attack the patient's body. T…

This study tests whether removing a smaller amount of healthy skin around a melanoma (narrow excision) works as well as the standard wider removal. About 1,000 adults with early-stage invasive melanoma will take part. The goal is to see if the narrower approach reduces side effec…

This study tests whether adding the immunotherapy drug mosunetuzumab to standard chemotherapy is safe and works better for people with a fast-growing type of lymphoma that has a specific genetic change (c-Myc rearrangement). About 30 adults aged 18-75 who have not been treated be…

This study tests a combination of two drugs—glofitamab and ibrutinib—plus a pretreatment drug called obinutuzumab for people with mantle cell lymphoma who are 65 or older, or younger adults with high-risk features. The goal is to see if this combo is safe and can shrink or elimin…

This study tests whether combining three drugs—axatilimab, retifanlimab, and paclitaxel—is safe and works against advanced or metastatic solid tumors. About 38 adults with tumors that have spread will receive the combination. The goal is to find the best dose and see if the treat…

This early-phase study tests a targeted drug called pemigatinib given after standard chemotherapy for people newly diagnosed with acute myeloid leukemia (AML). The drug blocks a protein (FGFR) that may help leukemia cells grow. The main goal is to find the safest dose and see if …

This study tests a new combination of drugs for people newly diagnosed with a specific type of acute myeloid leukemia (AML). The treatment uses venetoclax, which blocks a protein that helps cancer cells survive, along with three chemotherapy drugs. The goal is to see if this comb…

This study tests whether adding venetoclax to a standard chemotherapy regimen (FLAG IDA) can better eliminate leukemia cells in people newly diagnosed with acute myeloid leukemia (AML). About 102 adults aged 18 to 65 will be randomly assigned to receive either the new combination…

This early-phase study tests a combination of three drugs (tafasitamab, acalabrutinib, and obinutuzumab) in people with previously untreated chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL). The goal is to check safety and see how well the drugs work togethe…

This study tests whether giving chemotherapy drugs directly into the spinal fluid can prevent serious brain-related side effects in people receiving CAR T-cell therapy for blood cancers. About 20-70% of CAR T-cell patients experience neurotoxicity, which can cause confusion, hall…

This study compares a new MRI technique called aMRI to standard PET scans for measuring brain tumor activity in people with glioma. aMRI uses special analysis of regular MRI images to show tumor metabolism without needing radioactive tracers. If successful, aMRI could offer a saf…

This study tests whether using two contrast agents (gadolinium and ferumoxytol) in one MRI session can improve the detection of brain abnormalities like tumors or nerve disorders. About 150 people with neurological symptoms or brain lesions will be scanned. The goal is to see if …

This study tests whether taking a daily fiber supplement can change the types of bacteria living in the colon. The goal is to see if these changes might help prevent precancerous polyps from forming. About 120 adults with benign anal conditions or getting a routine colonoscopy wi…

This study tests whether the heart medication amiodarone can prevent atrial fibrillation (a fast, irregular heartbeat) in people recovering from minimally invasive esophageal cancer surgery. Atrial fibrillation is a common complication after this surgery, and there is no standard…

This study looks at whether creative arts like drawing, painting, and sculpting can help children with cancer feel better and improve their quality of life. Researchers will compare art activities to watching videos in 72 children aged 8 to 13 who were diagnosed with cancer in th…

This study looks at whether getting immunotherapy in the morning or afternoon changes how well it fights advanced or metastatic solid tumors. Researchers believe the body's internal clock (circadian rhythm) might affect immune response. About 160 adults with certain cancers like …

This study tests an internet-based program that combines weight loss and resistance training to help men who have had prostate cancer and hormone therapy. The goal is to reduce obesity and frailty, which can improve quality of life and lower the risk of falls. About 250 men will …

This study tests if olanzapine, a drug that affects brain chemicals, can help cancer patients who have lost their appetite and weight. The trial includes 66 adults with advanced lung, stomach, or colorectal cancers who are not being treated with a goal to cure. Participants will …

This study tests whether adding social support to group exercise helps older men (65+) with prostate cancer feel less lonely and improve their mental and physical health. 150 men will be assigned to one of three 6-month programs: socially-enhanced group exercise, standard group e…

This study is for people with pancreatic cancer that can be removed by surgery or has spread. Researchers will give one of several drugs (cobimetinib, olaparib, onvansertib, azenosertib, AZD5305, or tremelimumab) for a short time before surgery or biopsy. By comparing tumor sampl…

This study looks at whether a simple blood test can help doctors decide if rectal cancer patients can avoid surgery and keep their rectum. Researchers will measure tiny bits of tumor DNA in the blood (ctDNA) before, during, and after standard treatment in 50 adults with stage II …

This study aims to see if a statewide educational campaign can help people in Oregon spot the early signs of melanoma, a serious skin cancer. Researchers will compare awareness and early detection rates in Oregon with neighboring states that did not receive the campaign. Up to 75…

This early phase 1 trial is studying how the drug OMO-103 affects pancreatic cancer cells in 12 patients with advanced or metastatic disease. The main goal is to see if the drug causes measurable changes in the tumor's biology by comparing tissue samples taken before and after tr…

This study looks at how hormonal therapy changes a protein called PSMA in prostate cancer cells, both in cancers that respond to hormone treatment and those that don't. Researchers will track 80 men with prostate cancer to see how PSMA levels change shortly after starting therapy…

This study offers free genetic testing to the general public to find people with inherited cancer syndromes, like hereditary breast and ovarian cancer or Lynch syndrome. Researchers want to see if broad testing is better than only testing those with a family history. Up to 27,500…

This study looks at how sex and gender might change the side effects people experience during immunotherapy for cancer. Researchers will track symptoms and quality of life in 100 adults starting standard immunotherapy. The goal is to better understand these differences to improve…

This study looks at whether CAR-T cell therapy reduces the protection that vaccines (like measles, mumps, and rubella) provide in people with multiple myeloma and non-Hodgkin lymphoma. Researchers will measure antibody levels before and after CAR-T treatment in 45 adults. The goa…