Less may be more: smaller surgery for melanoma tested in 1,000-Patient trial

NCT ID NCT06673095

Recruiting now Disease control Sponsor: OHSU Knight Cancer Institute Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether removing a smaller border of healthy tissue around a melanoma (narrow excision) works as well as the standard wider excision. About 1,000 adults with early-stage melanoma will be randomly assigned to one of the two surgeries. The goal is to see if narrow excision can reduce complications and improve quality of life without increasing the chance of the cancer coming back.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: surgical excision (narrow margin vs wide margin)
What this could lead to: If narrow excision works as well as wide excision, it could become the new standard for early-stage melanoma, reducing surgical side effects and improving recovery.
What could go wrong: This is a Phase 2/3 trial, so results are not yet proven. Narrow excision might lead to higher local recurrence rates, and the study is still recruiting.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

cutaneous melanoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CLINICAL STAGE IA CUTANEOUS MELANOMA AJCC V8 CLINICAL STAGE IB CUTANEOUS MELANOMA AJCC V8

Contacts and locations

Locations

OHSU Knight Cancer Institute
RECRUITING

Portland, Oregon, 97239, United States
University Hospitals Cleveland Medical Center
NOT_YET_RECRUITING

Cleveland, Ohio, 44106, United States
University of California, Davis
NOT_YET_RECRUITING

Davis, California, 95817, United States
University of Kentucky/Markey Cancer Center
NOT_YET_RECRUITING

Lexington, Kentucky, 40536, United States
University of Michigan
NOT_YET_RECRUITING

Ann Arbor, Michigan, 48109, United States

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