Spinal chemotherapy may stop brain damage from cancer treatment
NCT ID NCT06895473
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This phase 2 trial tests whether injecting chemotherapy drugs (cytarabine, methotrexate, and hydrocortisone) into the spinal fluid can prevent severe brain side effects in people receiving CAR T-cell therapy for blood cancers. About 20-70% of CAR T patients develop neurotoxicity, which can cause confusion, seizures, or brain swelling. The study will enroll 26 adults and track how many develop serious brain symptoms.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- cytarabine, methotrexate, and hydrocortisone injected into the spinal fluid
- What this could lead to
- If it works, this could make CAR T-cell therapy safer by preventing serious brain side effects, allowing more patients to benefit from this cancer treatment.
- What could go wrong
- This is a small, early-phase trial with only 26 participants, so results may not apply to everyone. The spinal injections themselves carry risks like headache or infection.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for HEMATOPOIETIC AND LYMPHATIC SYSTEM NEOPLASM are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
OHSU Knight Cancer Institute
RECRUITINGPortland, Oregon, 97239, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- A virtual pharmacy visit may ease opioid fears for cancer patients
- Can meditation tame the Long-Term side effects of a stem cell transplant?
- Strumming through treatment: can ukulele lessons shield teen brains from Radiation's toll?
- A smartphone app may help young cancer survivors get fitter — a trial puts it to the test
- Faith and mindfulness join forces to heal black cancer survivors
- Sniffing away sickness: essential oils tested for chemo nausea