Radiation boosts immune attack on stubborn GI cancers?

NCT ID NCT04221893

First seen Nov 01, 2025 · Last updated May 10, 2026 · Updated 25 times

Summary

This study is for people with advanced gastrointestinal cancers that are spreading and no longer responding to immunotherapy. Researchers want to see if adding targeted radiation to one tumor can help the immune system fight cancer throughout the body. About 28 participants will receive radiation while continuing immunotherapy, and doctors will monitor tumor shrinkage and immune response.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • John Muir Medical Center-Walnut Creek

    NOT_YET_RECRUITING

    Walnut Creek, California, 94598, United States

    Contact

  • University of California, San Francisco

    RECRUITING

    San Francisco, California, 94143, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

Conditions

Explore the condition pages connected to this study.

METASTATIC ANAL CANAL CARCINOMA METASTATIC COLORECTAL CARCINOMA METASTATIC ESOPHAGEAL CARCINOMA METASTATIC GASTRIC CARCINOMA METASTATIC GASTROESOPHAGEAL JUNCTION ADENOCARCINOMA METASTATIC HEPATOCELLULAR CARCINOMA METASTATIC MALIGNANT DIGESTIVE SYSTEM NEOPLASM METASTATIC SMALL INTESTINAL CARCINOMA PANCREATOBILIARY CARCINOMA PATHOLOGIC STAGE IV GASTRIC CANCER AJCC V8 PATHOLOGIC STAGE IV GASTRIC CANCER AJCC V8 PATHOLOGIC STAGE IVA ESOPHAGEAL ADENOCARCINOMA AJCC V8 PATHOLOGIC STAGE IVA ESOPHAGEAL ADENOCARCINOMA AJCC V8 PATHOLOGIC STAGE IVA ESOPHAGEAL SQUAMOUS CELL CARCINOMA AJCC V8 PATHOLOGIC STAGE IVA ESOPHAGEAL SQUAMOUS CELL CARCINOMA AJCC V8 PATHOLOGIC STAGE IVB ESOPHAGEAL ADENOCARCINOMA AJCC V8 PATHOLOGIC STAGE IVB ESOPHAGEAL ADENOCARCINOMA AJCC V8 PATHOLOGIC STAGE IVB ESOPHAGEAL SQUAMOUS CELL CARCINOMA AJCC V8 PATHOLOGIC STAGE IVB ESOPHAGEAL SQUAMOUS CELL CARCINOMA AJCC V8 PATHOLOGIC STAGE IVB GASTROESOPHAGEAL JUNCTION ADENOCARCINOMA AJCC V8 PATHOLOGIC STAGE IVB GASTROESOPHAGEAL JUNCTION ADENOCARCINOMA AJCC V8 POSTNEOADJUVANT THERAPY STAGE IV ESOPHAGEAL SQUAMOUS CELL CARCINOMA AJCC V8 POSTNEOADJUVANT THERAPY STAGE IV ESOPHAGEAL SQUAMOUS CELL CARCINOMA AJCC V8 POSTNEOADJUVANT THERAPY STAGE IV GASTRIC CANCER AJCC V8 POSTNEOADJUVANT THERAPY STAGE IV GASTRIC CANCER AJCC V8 POSTNEOADJUVANT THERAPY STAGE IV GASTROESOPHAGEAL JUNCTION ADENOCARCINOMA AJCC V8 POSTNEOADJUVANT THERAPY STAGE IV GASTROESOPHAGEAL JUNCTION ADENOCARCINOMA AJCC V8 POSTNEOADJUVANT THERAPY STAGE IVA ESOPHAGEAL ADENOCARCINOMA AJCC V8 POSTNEOADJUVANT THERAPY STAGE IVA ESOPHAGEAL ADENOCARCINOMA AJCC V8 POSTNEOADJUVANT THERAPY STAGE IVA ESOPHAGEAL SQUAMOUS CELL CARCINOMA AJCC V8 POSTNEOADJUVANT THERAPY STAGE IVA ESOPHAGEAL SQUAMOUS CELL CARCINOMA AJCC V8 POSTNEOADJUVANT THERAPY STAGE IVA GASTROESOPHAGEAL JUNCTION ADENOCARCINOMA AJCC V8 POSTNEOADJUVANT THERAPY STAGE IVA GASTROESOPHAGEAL JUNCTION ADENOCARCINOMA AJCC V8 POSTNEOADJUVANT THERAPY STAGE IVB ESOPHAGEAL ADENOCARCINOMA AJCC V8 POSTNEOADJUVANT THERAPY STAGE IVB ESOPHAGEAL ADENOCARCINOMA AJCC V8 POSTNEOADJUVANT THERAPY STAGE IVB ESOPHAGEAL SQUAMOUS CELL CARCINOMA AJCC V8 POSTNEOADJUVANT THERAPY STAGE IVB ESOPHAGEAL SQUAMOUS CELL CARCINOMA AJCC V8 POSTNEOADJUVANT THERAPY STAGE IVB GASTROESOPHAGEAL JUNCTION ADENOCARCINOMA AJCC V8 POSTNEOADJUVANT THERAPY STAGE IVB GASTROESOPHAGEAL JUNCTION ADENOCARCINOMA AJCC V8 STAGE IV ADENOCARCINOMA OF THE GASTROESOPHAGEAL JUNCTION STAGE IV ANAL CANCER AJCC V8 STAGE IV COLORECTAL CANCER AJCC V8 STAGE IV COLORECTAL CANCER AJCC V8 STAGE IV ESOPHAGEAL ADENOCARCINOMA STAGE IV ESOPHAGEAL ADENOCARCINOMA STAGE IV ESOPHAGEAL SQUAMOUS CELL CARCINOMA STAGE IV ESOPHAGEAL SQUAMOUS CELL CARCINOMA STAGE IV GASTRIC CANCER STAGE IV GASTRIC CANCER STAGE IV HEPATOCELLULAR CARCINOMA AJCC V8 STAGE IV HEPATOCELLULAR CARCINOMA AJCC V8 STAGE IVA ADENOCARCINOMA OF THE GASTROESOPHAGEAL JUNCTION STAGE IVA ADENOCARCINOMA OF THE GASTROESOPHAGEAL JUNCTION STAGE IVA COLORECTAL CANCER AJCC V8 STAGE IVA COLORECTAL CANCER AJCC V8 STAGE IVA ESOPHAGEAL ADENOCARCINOMA STAGE IVA ESOPHAGEAL ADENOCARCINOMA STAGE IVA ESOPHAGEAL SQUAMOUS CELL CARCINOMA STAGE IVA ESOPHAGEAL SQUAMOUS CELL CARCINOMA STAGE IVA GASTRIC CANCER STAGE IVA GASTRIC CANCER STAGE IVA HEPATOCELLULAR CARCINOMA AJCC V8 STAGE IVA HEPATOCELLULAR CARCINOMA AJCC V8 STAGE IVB COLORECTAL CANCER AJCC V8 STAGE IVB COLORECTAL CANCER AJCC V8 STAGE IVB ESOPHAGEAL ADENOCARCINOMA STAGE IVB ESOPHAGEAL ADENOCARCINOMA STAGE IVB ESOPHAGEAL SQUAMOUS CELL CARCINOMA STAGE IVB ESOPHAGEAL SQUAMOUS CELL CARCINOMA STAGE IVB GASTRIC CANCER STAGE IVB GASTRIC CANCER STAGE IVB GASTROESOPHAGEAL JUNCTION ADENOCARCINOMA STAGE IVB GASTROESOPHAGEAL JUNCTION ADENOCARCINOMA STAGE IVB HEPATOCELLULAR CARCINOMA AJCC V8 STAGE IVB HEPATOCELLULAR CARCINOMA AJCC V8 STAGE IVC COLORECTAL CANCER AJCC V8