New combo therapy aims to outsmart advanced liver cancer
NCT ID NCT05168163
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This phase II trial tests whether adding the immunotherapy drug atezolizumab to a targeted therapy (cabozantinib or lenvatinib) works better than the targeted therapy alone for people with advanced liver cancer that cannot be surgically removed. The study enrolls 122 adults whose cancer has progressed after prior treatment with atezolizumab plus bevacizumab. Researchers will measure overall survival and progression-free survival to see if the combination improves outcomes.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
atezolizumab (immunotherapy) plus cabozantinib or lenvatinib (kinase inhibitors)
What this could lead to
If successful, this could provide a new treatment option for advanced liver cancer patients whose disease has progressed after initial immunotherapy.
What could go wrong
This is a phase II trial with only 122 participants, so results are preliminary. Adding atezolizumab may increase side effects without improving survival.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Allegheny General Hospital
RECRUITINGPittsburgh, Pennsylvania, 15212, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Carle Cancer Center NCI Community Oncology Research Program
RECRUITINGUrbana, Illinois, 61801, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Cleveland Clinic Weston Florida
WITHDRAWNWeston, Florida, 33331, United States
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Duke University Medical Center
COMPLETEDDurham, North Carolina, 27710, United States
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Froedtert and the Medical College of Wisconsin LAPS
RECRUITINGMilwaukee, Wisconsin, 53226, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Mayo Clinic in Arizona
RECRUITINGScottsdale, Arizona, 85259, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Mayo Clinic in Florida
WITHDRAWNJacksonville, Florida, 32224-9980, United States
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Mayo Clinic in Rochester
RECRUITINGRochester, Minnesota, 55905, United States
Contact Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Medical College of Wisconsin
RECRUITINGMilwaukee, Wisconsin, 53226, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Michigan Cancer Research Consortium NCORP
RECRUITINGAnn Arbor, Michigan, 48106, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Rapid City Regional Hospital
RECRUITINGRapid City, South Dakota, 57701, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Roswell Park Cancer Institute
RECRUITINGBuffalo, New York, 14263, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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University Hospitals Cleveland Medical Center
WITHDRAWNCleveland, Ohio, 44106, United States
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University Medical Center New Orleans
RECRUITINGNew Orleans, Louisiana, 70112, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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University of Chicago Comprehensive Cancer Center
NOT_YET_RECRUITINGChicago, Illinois, 60637, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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University of Michigan Comprehensive Cancer Center
NOT_YET_RECRUITINGAnn Arbor, Michigan, 48109, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact