New hope for advanced cancers? first human trial launches

NCT ID NCT06427941

Recruiting now Disease control Sponsor: BeOne Medicines Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jul 30, 2026 · Updated 5 times

Summary

This early-stage study is testing a new drug called BGB-B2033, alone or with other drugs, in people with advanced liver, stomach, or lung cancers. The goal is to see if it is safe and how well it works. About 392 participants will take part.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: BGB-B2033, tislelizumab, bevacizumab
What this could lead to: If it works, this could point toward a new treatment option for certain advanced cancers like liver, stomach, and lung cancer.
What could go wrong: This is a very early (Phase 1) study, so the drug may not work or could have serious side effects. It is also small and not yet tested in many people.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

extragonadal germ cell tumor gastric cancer hepatocellular carcinoma metastatic malignant neoplasm non-small cell squamous lung carcinoma nongerminomatous germ cell tumor Simpson-Golabi-Behmel syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADVANCED HEPATOCELLULAR CARCINOMA ALPHA-FETOPROTEIN (AFP)-PRODUCING GASTRIC CANCER EXTRAGONADAL YOLK SAC TUMORS GLYPICAN-3 (GPC3)-POSITIVE SQUAMOUS NON-SMALL CELL LUNG CANCER LOCAL ADVANCED HEPATOCELLULAR CARCINOMA METASTATIC HEPATOCELLULAR CARCINOMA METASTATIC SOLID TUMOR

Contacts and locations

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Study contacts

Contact

Email: •••••@•••••

Locations

Anhui Provincial Hospital
RECRUITING

Hefei, Anhui, 230000, China
Asan Medical Center
RECRUITING

SongpaGu, Seoul Teugbyeolsi, 05505, South Korea
Auckland City Hospital
RECRUITING

Auckland, 1023, New Zealand
Cancer Institute Hospital of Jfcr
RECRUITING

Kotoku, Tokyo, 135-8550, Japan
Centre Hospitalier Universitaire Nantes Hotel Dieu
RECRUITING

Nantes, 44000, France
Centro Gaucho Integrado de Oncologia Hospital Mae de Deus
RECRUITING

Porto Alegre, 90110-270, Brazil
Cha Bundang Medical Center, Cha University
RECRUITING

BundangGu SeongnamSi, Gyeonggi-do, 13496, South Korea
Chongqing University Cancer Hospital
RECRUITING

Chongqing, Chongqing Municipality, 400030, China
Chungbuk National University Hospital
RECRUITING

Cheongju-si, Chungcheongbukdo, 28644, South Korea
City of Hope Chicago Cancer Center
RECRUITING

Zion, Illinois, 60099, United States
City of Hope National Medical Center
RECRUITING

Duarte, California, 91010-3012, United States
City of Hope Phoenix Cancer Center
RECRUITING

Goodyear, Arizona, 85338, United States
Fondazione Policlinico Universitario Agostino Gemelli
RECRUITING

Roma, 00168, Italy
Fundacao Faculdade Regional de Medicina de Sao Jose Do Rio Preto
RECRUITING

São José do Rio Preto, 15090-000, Brazil
Guangxi Medical University Cancer Hospital Wuxiang Branch
RECRUITING

Nanning, Guangxi, 530201, China
Harbin Medical University Cancer Hospital
RECRUITING

Harbin, Heilongjiang, 150000, China
Hopital Beaujon
RECRUITING

Clichy, 92110, France
Hospital Da Bahia
RECRUITING

Salvador, 41810-011, Brazil
Hospital Oncologico
RECRUITING

Rio Piedras, 00935, Puerto Rico
Hunan Cancer Hospital
RECRUITING

Changsha, Hunan, 410013, China
Icesp Instituto Do Cancer Do Estado de Sao Paulo Octavio Frias de Oliveira
RECRUITING

São Paulo, 01246-000, Brazil
Institut Gustave Roussy
RECRUITING

Villejuif, 94800, France
Iov Istituto Oncologico Veneto Irccs
RECRUITING

Padova, 35128, Italy
Irccs Humanitas Research Hospital
RECRUITING

Rozzano, 20089, Italy
Irccs Istituto Nazionale Tumori Fondazione Pascale
RECRUITING

Naples, 80131, Italy
Kindai University Hospital
RECRUITING

Sakai, Osaka, 590-0197, Japan
Lishui Central Hospital
RECRUITING

Lishui, Zhejiang, 323000, China
Memorial Sloan Kettering Cancer Center Mskcc
RECRUITING

New York, New York, 10065-6800, United States
Mengchao Hepatobiliary Hospital of Fujian Medical University
RECRUITING

Fuzhou, Fujian, 350028, China
Nanfang Hospital of Southern Medical University
RECRUITING

Guangzhou, Guangdong, 510515, China
Samsung Medical Center
RECRUITING

GangnamGu, Seoul Teugbyeolsi, 06351, South Korea
Scri Oncology Partners
RECRUITING

Nashville, Tennessee, 37203-1503, United States
Seoul National University Bundang Hospital
RECRUITING

Seongnam-si, Gyeonggi-do, 13620, South Korea
Seoul National University Hospital
RECRUITING

Seoul, Seoul Teugbyeolsi, 03080, South Korea
Severance Hospital Yonsei University Health System
RECRUITING

SeodaemunGu, Seoul Teugbyeolsi, 03722, South Korea
Sichuan Cancer Hospital and Institute
RECRUITING

Chengdu, Sichuan, 610041, China
The Affiliated Hospital of Xuzhou Medical University
RECRUITING

Xuzhou, Jiangsu, 221000, China
The First Affiliated Hospital of Wenzhou Medical University
RECRUITING

Wenzhou, Zhejiang, 325000, China
The First Affiliated Hospital, Zhejiang University School of Medicine
RECRUITING

Hangzhou, Zhejiang, 310003, China
The Fourth Hospital of Hebei Medical University
RECRUITING

Shijiazhuang, Hebei, 050011, China
The Second Affiliated Hospital of Nanchang University
RECRUITING

Nanchang, Jiangxi, 330006, China
The Second Affiliated Hospital of Nanchang Universityhongjiaozhou Branch
RECRUITING

Nanchang, Jiangxi, 330038, China
The University of Texas Md Anderson Cancer Center
RECRUITING

Houston, Texas, 77030-4009, United States
Tokyo Metropolitan Komagome Hospital
RECRUITING

Bunkyoku, Tokyo, 113-8677, Japan
Tongji Hospital of Tongji Medical College Huazhong University of Science and Technology
RECRUITING

Wuhan, Hubei, 430030, China
Union Hospital of Tongji Medical College, Huazhong University of Science and Technology
RECRUITING

Wuhan, Hubei, 430022, China
Upmc Hillman Cancer Center(Univ of Pittsburgh)
RECRUITING

Pittsburgh, Pennsylvania, 15232-1309, United States
Zhujiang Hospital of Southern Medical University
RECRUITING

Guangzhou, Guangdong, 510000, China

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