Radiation and immunotherapy join forces against Hard-to-Treat liver metastases
NCT ID NCT06794086
First seen Jun 30, 2026 · Last updated Jul 01, 2026 · Updated 1 time
Summary
This study tests whether combining a precise form of radiation (SBRT) with an immunotherapy drug (PD-1 monoclonal antibody) can help people whose colorectal cancer has spread to the liver and cannot be removed surgically. The trial enrolls adults aged 18 to 75 with a specific type of colorectal cancer (pMMR/MSS). The goal is to see if this combination shrinks tumors and improves outcomes, while monitoring for side effects.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- PD-1 monoclonal antibody (a type of immunotherapy) plus stereotactic body radiation therapy (SBRT, a precise form of radiation)
- What this could lead to
- If successful, this combination could offer a new treatment option for people with colorectal cancer that has spread to the liver and cannot be removed by surgery, potentially shrinking tumors and improving survival.
- What could go wrong
- This is a small, early-phase study with only 24 participants, so results may not apply to everyone. The combination of radiation and immunotherapy can cause side effects such as fatigue, liver inflammation, or immune-related reactions.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Sixth Affiliated Hospital, Sun Yat-sen University
RECRUITINGGuangzhou, Guangdong, 510065, China
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