Blood test could unlock precision medicine for deadly TMA

NCT ID NCT04745195

Recruiting now Diagnosis Sponsor: Maastricht University Medical Center Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study is testing a new blood test (the HMEC test) to see if it can better identify which patients with thrombotic microangiopathy (TMA) have a specific immune system problem driving their disease. TMA is a severe condition that damages kidneys and the brain. The researchers hope this test will help doctors choose the right treatment for each patient. The study will enroll 42 adults with acute kidney injury and TMA.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: HMEC test (a blood test that measures complement activity on endothelial cells)
What this could lead to: If successful, this test could help doctors identify which TMA patients have complement-driven disease, leading to more targeted treatments and better outcomes.
What could go wrong: This is a small, early-stage study (42 participants) focused on diagnosis, not treatment. The test may not prove accurate enough for routine use, and results may not apply to all TMA patients.

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Conditions

The condition(s) this trial relates to.

antiphospholipid syndrome atypical hemolytic-uremic syndrome hemolytic-uremic syndrome malignant hypertension systemic lupus erythematosus systemic sclerosis thrombotic microangiopathy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEMOLYTIC UREMIC SYNDROME, ATYPICAL HEMOLYTIC-UREMIC SYNDROME THROMBOTIC MICROANGIOPATHIES

Contacts and locations

Locations

Maastricht University Medical Center
RECRUITING

Maastricht, Limburg, 6229HX, Netherlands

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