CHRONIC KIDNEY DISEASES

This study is testing if an automated insulin pump system can help people who have both diabetes and advanced kidney disease. The system continuously monitors blood sugar and automatically delivers insulin, aiming to keep levels in a safe range. Researchers will compare this auto…

This study is testing whether a smartphone app can help people with kidney problems better manage fluid buildup and swelling. Participants will use the app daily to track their weight and blood pressure, and it will provide personalized instructions for adjusting their water pill…

This study aims to find the safest duration for patients with advanced kidney disease to take two blood-thinning medications after receiving a heart stent. Researchers will compare different treatment lengths to see which one best prevents heart attacks and strokes while causing …

This study is testing a comprehensive support program to help people better manage multiple chronic conditions like high blood pressure, diabetes, and kidney disease. It involves giving participants home blood pressure monitors and connecting them with a team including community …

This study is testing if mindfulness meditation can help calm an overactive nervous system in people with chronic kidney disease (CKD), which is linked to high blood pressure and heart risk. Researchers also want to see if a gentle, non-invasive device that stimulates a nerve in …

This early-stage study is testing whether stem cells taken from amniotic fluid can help heal the extremely painful and dangerous skin wounds caused by calciphylaxis, a rare complication of kidney disease. Nine adult patients with calciphylaxis will receive the stem cell treatment…

This study aims to see if two common, low-cost drugs can safely reduce dangerous bleeding during surgery for people with advanced kidney disease. It will enroll 100 patients with severe kidney problems who are having non-heart surgery. The trial is a pilot to prepare for a larger…

This study is testing whether suddenly ill adults with conditions like infections, heart failure, or breathing problems can be safely treated at home instead of in a hospital. About 3,000 participants will receive hospital-level care at home with doctors, nurses, tests, and treat…

This study is testing the safety and early effectiveness of a new medical procedure that targets nerves in both the kidney and liver to help lower blood pressure. It is for adults with uncontrolled high blood pressure, including those with other heart or kidney risks. The goal is…

This study is testing if home blood pressure monitoring with extra support from a nurse case manager works better than monitoring alone for people with kidney disease and high blood pressure who live far from clinics. About 150 patients in remote Northern Alberta will use a smart…

This study is testing a new, dissolvable wrap called SelfWrap that is placed around a surgically created blood vessel connection (fistula) used for dialysis. The goal is to see if the wrap helps the fistula develop properly and last longer while reducing complications, compared t…

This study is testing if a 12-week online exercise program can help teens with chronic kidney disease become more active. Researchers want to see if getting teens to do just 15 more minutes of moderate activity each day can improve their health and quality of life. The program us…

This study is testing a smartphone app designed to help older adults with multiple chronic conditions like heart failure, diabetes, and kidney disease manage their care after leaving the hospital. The goal is to see if the app can reduce complications and readmissions by providin…

This study is testing whether doing handgrip exercises at home for 8 weeks can help improve blood pressure in people with chronic kidney disease (CKD). Researchers will enroll 50 adults with moderate CKD who don't exercise regularly to perform the grip training three times per we…

This study is testing whether a gentle, non-invasive shockwave treatment applied to the kidneys can help lower high blood pressure and improve kidney health in people with chronic kidney disease. Thirty patients will be randomly assigned to receive either the real treatment or a …

This study is testing if a single dose of a supplement called equol, which comes from soy, can quickly improve blood vessel function in postmenopausal women. It aims to see if this could be a potential way to help lower the high risk of heart disease in women with chronic kidney …

This large international trial aims to find the best treatments to slow the progression of chronic kidney disease (CKD) and prevent kidney failure. It will test multiple medications or combinations in adults with CKD over two-year periods. The innovative 'platform' design allows …

This study is testing whether colchicine, a low-cost anti-inflammatory medication, can help protect the heart in people with chronic kidney disease. It will involve about 20 participants to see if the drug improves heart function and reduces inflammation. The goal is to find a ne…

This study is testing whether stem cells taken from bone marrow are safe for people with chronic kidney disease, including those who have had a kidney transplant. Researchers will give these cells to 75 adults and closely monitor them for any side effects. The goal is to see if t…

This study is testing a new program where a team of healthcare professionals reviews and safely reduces unnecessary medications for people with chronic kidney disease. The goal is to see if this 'deprescribing' approach improves patients' quality of life, reduces hospital visits,…

This study tests a new support program for low-income patients with chronic diseases like diabetes and heart problems after they leave the hospital. It provides free medications, delivers them to the bedside and then to the home, and offers a coach to help with follow-up care. Re…

This study is testing if home-delivered fruits and vegetables can help manage acid buildup in people with chronic kidney disease, as an alternative to standard medication. It will enroll 40 adults with moderate kidney disease and mild acidosis to see if this dietary approach is p…

This study is testing if a drug called Lokelma (SZC), which lowers potassium, can help elderly patients with both heart failure and chronic kidney disease safely take higher, more effective doses of their standard heart medications. Many patients cannot take the full recommended …

This early-stage study is testing a new approach for people who have already received a kidney transplant from a well-matched family donor. Researchers want to see if giving patients stem cells from the same donor, after a special preparation treatment, can teach their immune sys…

This study is testing if a drug called patiromer can help people with moderate to severe chronic kidney disease safely take higher doses of a common kidney-protecting blood pressure medication (irbesartan). In this 44-person trial, participants will try both patiromer and a place…

This study is testing if a medication called empagliflozin can help children with chronic kidney disease. Researchers want to see if running this type of trial is practical and if the drug improves blood, urine, and heart health markers over three months. Forty children will be r…

This study is testing if a faster version of a kidney nerve-calming procedure works as well as the older, longer method to lower high blood pressure. It will involve about 130 adults whose blood pressure remains high despite treatment. Researchers aim to see if simplifying where …

This study is testing whether injecting a person's own processed kidney cells back into their kidneys can slow or stop the progression of kidney disease caused by type 2 diabetes. About 685 participants will be randomly assigned to receive either the real cell injections or a sim…

This study is testing a new imaging technology called dynamic full-field optical coherence tomography to see if it can help doctors analyze kidney biopsies faster and more accurately. Researchers will compare this new method to standard biopsy analysis in 50 adult patients with s…

This study is testing a new type of ultrasound called shear wave elastography to see if it can help doctors quickly figure out if a patient's kidney problem is a new, sudden issue (acute) or a long-term condition (chronic). The test will be given to 800 adults in a hospital emerg…

This small pilot study aims to see if a 12-week program of fast-paced, low-weight strength training is safe and practical for older adults with advanced kidney disease. Researchers will compare the exercise program to a healthy lifestyle education group. The main goal is to gathe…

This study is testing the safety of a drug called difelikefalin for teenagers on kidney dialysis who suffer from moderate to severe itching. It aims to see if the drug is safe for adolescents, as it is already used for adults. About 18 participants aged 12 to 17 will receive the …

This small pilot study is testing whether a non-invasive device that gently stimulates a nerve through the ear can help regulate the nervous system in people with chronic kidney disease. The main goals are to see if the device is safe and tolerable for patients to use for two wee…

This study is testing two new treatment strategies for depression in people with chronic kidney disease (CKD). Researchers will compare a 16-week program of either a specific type of talk therapy (delivered remotely) or a non-SSRI antidepressant medication, with the option to add…

This study is testing new, simpler methods to measure how well kidneys can respond to stress, called 'kidney reserve.' It involves people with sickle cell disease affecting their kidneys or people who have donated a kidney. Participants will have their kidney function checked bef…

This study aims to understand why kidney disease happens, gets worse, or leads to complications like infections or heart problems. Researchers will follow 5,000 adult patients with or at risk for kidney disease for 10 years, collecting blood and urine samples. They will analyze t…

This study aims to understand how being born prematurely affects kidney development and long-term health. Researchers will follow 300 preterm babies for up to 10 years, using blood tests, urine tests, and ultrasounds to track kidney growth and function. The goal is to identify ea…

This study aims to learn more about kidney disease in people with Type 2 diabetes. Researchers will collect kidney tissue and other samples from 300 participants to look for patterns that can improve diagnosis and predict how the disease might progress. The goal is to gather know…

This early-stage study aims to understand how a sedative drug called remimazolam works in people undergoing kidney transplant surgery. Researchers will measure how the drug moves through the body and how well it keeps patients sedated during the procedure. The goal is to gather i…

This study follows 200 people with advanced kidney disease as they start dialysis treatment. Researchers want to understand how quality of life and physical frailty change over the first year, comparing patients who choose home dialysis with those who go to a clinic for treatment…

This study aims to understand how common obstructive sleep apnea is in people with chronic kidney disease (CKD) and whether having sleep apnea makes kidney disease worse over time. Researchers will follow 356 adults with moderate CKD for a long period to identify risk factors and…

This study aims to understand how challenges like unstable housing, food insecurity, and financial strain affect the health of African American adults living with both chronic kidney disease and type 2 diabetes. Researchers will interview participants and collect health data to i…

This study aims to understand how chronic kidney disease affects the brain and eyes, not to test a treatment. Researchers will follow 1,500 adults with kidney disease for three years, using brain scans, eye imaging, and memory tests to see if changes in these organs are connected…

This study aims to understand how chronic kidney disease affects the immune system, particularly why patients with advanced disease are more vulnerable to serious infections. Researchers will compare blood samples from 100 people across three groups: those with end-stage kidney d…

This study aims to find out how many patients at a specialized medical center have chronic kidney disease, and how many of those cases were previously unknown. Researchers will screen 3,000 adult patients who are already being seen at the clinic for other health issues. The study…

This study aims to understand how blood pressure and artery stiffness change between day and night in people at high risk for heart disease, including those with kidney problems. Researchers will measure these patterns in 120 participants over 24 hours on two separate occasions. …