CHRONIC KIDNEY DISEASES

This study tests whether colchicine, an anti-inflammatory drug, can improve heart function in people with chronic kidney disease. About 20 adults with mild to severe kidney disease will take colchicine or a placebo. The main goal is to see if the drug helps the heart pump better,…

This study is testing a smartphone app designed to help adults aged 55 and older who have multiple chronic conditions like heart failure, diabetes, and kidney disease. The app provides fall prevention tips, a personalized after-hospital care plan, and tools to track symptoms and …

This study looks at whether mindfulness meditation can improve nerve function in people with chronic kidney disease (CKD). It also tests if adding a gentle nerve stimulation device can boost these benefits. The goal is to help control blood pressure and restore balance in the bod…

This study tests several treatments to slow chronic kidney disease (CKD) and prevent kidney failure. About 1,000 adults with CKD will receive standard care plus one or more experimental agents. The goal is to find the best way to keep kidneys working longer and reduce the need fo…

This early-phase study at Mayo Clinic tests whether transplanting a kidney and a bladder together is possible and safe. It involves up to 30 people aged 1 to 60 with chronic kidney disease and bladder problems. The main goal is to see if the new bladder works well and improves qu…

This study looks at whether an automated insulin delivery system (the Medtronic 780G) can help adults with diabetes and advanced kidney disease manage their blood sugar better than their usual insulin injections. Participants will use the system for 8 weeks and then switch to the…

This study tests a new treatment using stem cells from amniotic membrane for people with calciphylaxis, a rare and painful condition where blood vessels harden and cause severe skin wounds. The treatment is given to 9 adults with chronic kidney disease to see if it helps wounds h…

This study tests a program that helps adults with uncontrolled high blood pressure plus diabetes or kidney disease. Participants use a home blood pressure monitor that sends readings to a care team, including a community health worker and a pharmacist. The goal is to see if this …

This study is testing whether a single or repeated infusion of donor stem cells is safe for people with chronic kidney disease, including those who have had a kidney transplant. The stem cells are taken from bone marrow and given through a vein or directly into the kidney arterie…

This study tests whether treating suddenly ill adults at home is as safe and effective as hospital care. About 3,000 participants with conditions like infections, heart failure, or COPD will receive hospital-level care at home. The goal is to see if home care can lower costs and …

This study tests whether patiromer, a drug that lowers potassium levels, allows people with moderate-to-severe chronic kidney disease to safely increase their dose of a common blood pressure medication (irbesartan). The goal is to see if this leads to better kidney protection and…

This study tests whether giving two medicines, tranexamic acid and desmopressin, before surgery can reduce bleeding in patients with kidney problems. About 100 adults with chronic kidney disease or acute kidney injury who need noncardiac surgery will take part. The goal is to see…

This study tests a faster version of a procedure called renal denervation, which uses energy to calm overactive nerves in the kidneys that can raise blood pressure. The goal is to see if the quicker approach works as well as the standard method for lowering blood pressure in peop…

This early-stage study tests whether a stem cell infusion from the same donor can allow kidney transplant recipients to safely stop taking lifelong anti-rejection medications. Ten adults with a well-functioning kidney from a matched living donor will receive the infusion after a …

This study looks at how long people with advanced chronic kidney disease should take two blood thinners (aspirin plus clopidogrel or prasugrel) after getting a heart stent. About 900 adults with severe kidney disease will be randomly assigned to either a short or long course of t…

This study tests a special wrap called SelfWrap placed around blood vessels during fistula creation for dialysis. The goal is to help the fistula mature faster and work without extra procedures. About 600 adults with chronic kidney disease needing a new fistula will take part. Th…

This study tests a pharmacy-led program to help low-income patients with multiple chronic conditions take their medications correctly after leaving the hospital. The program provides free medications, bedside delivery, and health coaches to address common barriers like cost and t…

This study tests whether a potassium-lowering drug (SZC) can help elderly patients (70+) with heart failure and chronic kidney disease safely increase their doses of RAASi medications, which are often limited by high potassium levels. About 94 participants will be randomly assign…

This study tests an experimental cell therapy called REACT (rilparencel) in 685 adults with type 2 diabetes and chronic kidney disease. Participants receive up to two injections of their own kidney cells or a sham procedure. The goal is to see if the treatment can slow the loss o…

This study tests whether gentle shockwave therapy to the kidneys can help lower blood pressure and improve kidney function in people with chronic kidney disease and high blood pressure. 30 adults will receive either real or sham treatments over three weeks. The goal is to see if …

This study tests a deprescribing program for adults with chronic kidney disease (CKD) in Qatar. The goal is to safely reduce or replace unnecessary medications that can cause side effects or lower quality of life. About 424 participants on dialysis or pre-dialysis will be randoml…

This study tests a device that uses energy to calm overactive nerves in the kidney and liver, which may help lower blood pressure. It is for adults aged 18 to 80 with uncontrolled high blood pressure, with or without other health risks like heart or kidney disease. The goal is to…

This study looks at whether checking blood pressure at home and sharing readings with a case manager can improve blood pressure control for people with chronic kidney disease who live far from clinics. About 146 adults in northern Alberta will either use home monitoring with usua…

This study is testing a new imaging technique called dynamic full-field optical coherence tomography (OCT) to analyze kidney biopsy samples. The goal is to see if this method can quickly and accurately identify signs of acute kidney injury or chronic kidney disease, compared to t…

This study tests a special ultrasound technique called shear wave elastography to help doctors quickly tell if kidney disease is acute (new) or chronic (long-standing). The goal is to make diagnosis faster and safer for patients in the emergency room, avoiding the need for contra…

This study aims to find better ways to treat depression in people with chronic kidney disease (CKD). About 201 adults with advanced CKD and major depression will receive either behavioral activation teletherapy plus a non-SSRI antidepressant, the antidepressant plus teletherapy, …

This study tests if a medicine called difelikefalin is safe for teenagers aged 12 to 17 who have severe itching due to kidney disease and are on dialysis. All 18 participants will receive the medicine during their regular dialysis visits for up to 12 weeks. The goal is to see if …

This study tests whether a 12-week physical activity program can help teens (ages 13-18) with chronic kidney disease (CKD) increase their daily moderate-to-vigorous exercise. Researchers will use Fitbits to track activity changes and gather feedback from participants. The goal is…

This study tests whether a small device that stimulates a nerve in the ear can safely help people with chronic kidney disease (stages 3-5) who have problems with their autonomic nervous system (which controls things like heart rate and blood pressure). Thirty participants will us…

This study tests a smartphone app that helps people with kidney disease manage body swelling by giving daily instructions on adjusting their water pill (diuretic) dose. Thirty participants will use the app for 90 days, entering their weight and blood pressure daily. The goal is t…

This study looks at whether a 6-month home walking program can improve memory, thinking skills, and brain structure in older adults with chronic kidney disease and mild memory problems. Researchers will compare the walking group to a health education group. The goal is to find a …

This study tests whether a 12-week high-velocity resistance training program is safe and doable for older adults with advanced chronic kidney disease. Researchers will compare the exercise group to a group that attends weekly healthy lifestyle sessions. The goal is to see if this…

This study looks at whether doing handgrip exercises at home for 8 weeks can help lower blood pressure in people with chronic kidney disease (stages 3 and 4). About 50 adults aged 45-85 who do not exercise regularly will take part. Researchers will measure blood pressure, artery …

This study follows 300 babies born early (preterm) and at full term to understand how early birth affects kidney and heart health later in life. Researchers use ultrasound and blood/urine tests to spot early warning signs of kidney disease and high blood pressure. The goal is to …

This study looks at whether a single dose of equol, a substance made when digesting soy, can improve blood vessel function in postmenopausal women. It includes 38 women aged 50-69, some with chronic kidney disease (CKD) and some healthy. Researchers will measure blood vessel heal…

This study looks at a rare but serious condition called calciphylaxis, where small blood vessels in the skin harden, often in people with advanced kidney disease. Researchers will compare 860 kidney disease patients with and without calciphylaxis to find clues about what causes i…

This study aims to better understand acute kidney injury and chronic kidney disease by analyzing kidney tissue from 1,000 volunteers. Researchers will use advanced technology to identify different disease subtypes and find new targets for therapies. The goal is to pave the way fo…

This study looks at why people with chronic kidney disease (CKD) often lose muscle mass and strength, a condition called sarcopenia. Researchers will follow 1,000 adults with CKD to find risk factors for sarcopenia and see how it affects their health over time. The goal is to bet…

This study looks at how chronic kidney disease weakens the immune system, specifically T-cells, in 100 patients. Researchers will analyze blood samples to understand the immune defects. They will also test a new method in the lab to engineer T-cells using mRNA, aiming to restore …

This study looks at whether it's possible to run a larger trial of a drug called empagliflozin (a type of SGLT2 inhibitor) in 40 children and teens with chronic kidney disease. Participants are randomly assigned to take the drug or continue usual care for 3 months. The goal is to…

This study will screen 3,000 adults at a major hospital to find out how many have chronic kidney disease without knowing it. Participants must be over 50 or over 18 with conditions like diabetes or high blood pressure. The goal is to measure how common undiagnosed kidney disease …

This study looks at how social needs—like food, housing, or safety—affect the health and self-care of African American adults with diabetic kidney disease. Researchers will talk with 330 participants to understand what helps or hinders their care, then design a program tailored t…

This study looks at how common sleep apnea is in people with chronic kidney disease (CKD) and whether it makes kidney function worse over time. Researchers will follow 356 adults with moderate to severe CKD who are not on dialysis. The goal is to find risk factors for sleep apnea…

This study looks at easier methods to measure how much extra work the kidneys can do (called renal reserve). About 44 adults with sickle cell kidney disease or who have donated a kidney will take a protein drink and have their kidney function checked. The goal is to find a practi…

This study looks at how chronic kidney disease affects the eyes, brain, and kidneys together. Researchers will use MRI scans and eye imaging to see if changes in the brain and retina are linked to memory problems and kidney function. About 1,500 adults with CKD will take part, bu…

This study follows 200 adults with advanced chronic kidney disease as they start dialysis at home or in a center. Researchers will track changes in quality of life, frailty, fatigue, and mood every 3 months for a year. The goal is to see if home dialysis helps patients stay healt…

This study looks at how dapagliflozin, a drug used for diabetes, affects heart and lung function in people with chronic kidney disease. Researchers will measure heart strain, oxygen use during exercise, and blood chemicals. The goal is to understand how the drug works, not to cur…

This study aims to better understand and diagnose diabetic kidney disease in people with type 2 diabetes. Researchers will collect kidney tissue and blood, urine, and stool samples from 300 participants to look for molecular and genetic patterns. The goal is to improve diagnosis …

This study aims to uncover the molecular mechanisms behind kidney disease, immune disorders, and complications in organ transplant patients. Researchers will analyze blood and urine samples from 5,000 participants to find genetic and protein markers that predict disease progressi…

This study looks at how the sedative remimazolam behaves in 30 adults receiving a kidney transplant. Researchers will measure drug levels in the blood and monitor how deeply patients are sedated. The goal is to learn more about the drug's effects, not to treat the kidney disease …

This study looks at how blood pressure and artery stiffness change between day and night in people at higher risk for heart disease, including those with kidney problems. Researchers will monitor 120 participants over 24 hours using wearable devices and collect blood and urine sa…