CHRONIC KIDNEY DISEASES

This study tests a team-based program to safely reduce unnecessary or risky medications for people with chronic kidney disease in Qatar. About 424 adults on dialysis or pre-dialysis will be randomly assigned to the program or usual care. The goal is to lower medication burden, im…

This study tests if giving two medicines—tranexamic acid and desmopressin—before surgery can reduce bleeding in people with kidney problems. About 100 adults with chronic kidney disease or acute kidney injury who need noncardiac surgery will take part. The goal is to see if these…

This study tests whether colchicine, an anti-inflammatory drug, can improve heart function in people with chronic kidney disease. Researchers will measure changes in heart strain and size using ultrasound. The trial enrolls 20 adults aged 21-80 with moderate to severe kidney dise…

This early-phase study tests whether it is possible to transplant a kidney and a bladder together in one surgery. It includes up to 30 people aged 1 to 60 who have chronic kidney disease along with bladder problems like neurogenic bladder or bladder absence. The main goal is to s…

This study aims to find better ways to treat depression in people with chronic kidney disease (CKD). About 201 adults with advanced CKD and major depression will receive either behavioral activation therapy, a different antidepressant (bupropion), or a placebo, with the option to…

This study looks at whether mindfulness meditation can improve nerve function in people with chronic kidney disease (CKD). It also tests if adding a gentle nerve stimulation device (tVNS) makes meditation work better. About 150 adults with moderate CKD will participate. The goal …

This study tests whether bone marrow stem cells are safe for people with chronic kidney disease, including those who have had a kidney transplant. About 75 adults will receive stem cells through a vein or directly into the kidney arteries. The goal is to monitor side effects, not…

This study is testing a new device that uses a procedure called denervation to calm overactive nerves in the kidney and liver, which may help lower blood pressure. It involves 175 adults with uncontrolled high blood pressure, with or without other health risks like heart or kidne…

This study tests several treatments to slow chronic kidney disease (CKD) and prevent kidney failure. About 1,000 adults with CKD will receive standard care plus one or more experimental agents. The goal is to find the best way to keep kidneys working longer and reduce the need fo…

This study looks at whether an automated insulin delivery system (the Medtronic 780G) can help adults with diabetes and advanced kidney disease manage their blood sugar better than their usual insulin injections. Participants will use the system for 8 weeks and then switch to the…

This study tests a program that helps adults with uncontrolled high blood pressure plus diabetes or kidney disease. Participants use a home blood pressure monitor that sends readings to a care team, including a community health worker and a pharmacist. The goal is to see if this …

This study tests a new treatment using stem cells from amniotic membrane for people with calciphylaxis, a rare and painful condition where blood vessels harden and cause severe skin wounds. The treatment is given to 9 adults with chronic kidney disease to see if it helps wounds h…

This study tests a streamlined version of a procedure called renal denervation, which uses energy to calm overactive nerves in the kidneys to lower blood pressure. The goal is to see if a faster approach works just as well as the standard method. About 130 adults with uncontrolle…

This study tests a special wrap called SelfWrap that is placed around blood vessels during dialysis access surgery. The goal is to help the access mature faster and work without needing extra procedures. About 600 adults with chronic kidney disease who need a new dialysis access …

This study tests whether patiromer, a drug that lowers potassium, allows people with chronic kidney disease to safely increase their dose of a common blood pressure medication (irbesartan). The goal is to see if this reduces protein in the urine and lowers blood pressure, which c…

This study tests a program to help low-income people with multiple chronic conditions take their medications correctly after leaving the hospital. The program provides free medications, delivers them to the bedside and home, and offers support from pharmacy staff. Researchers wil…

This study looks at whether using a home blood pressure monitor plus a dedicated case manager can help people with chronic kidney disease and high blood pressure living in remote areas better control their blood pressure. About 146 participants will either use the monitor with th…

This study tests an experimental cell therapy called REACT (rilparencel) in 685 adults with type 2 diabetes and chronic kidney disease. The goal is to see if up to two injections can slow the loss of kidney function compared to a sham procedure. Participants will be followed for …

This early-stage study tests whether a stem cell infusion from the same donor can allow kidney transplant recipients to safely stop taking lifelong anti-rejection medications. Ten adults with a well-functioning kidney from a matched living donor will receive the infusion after a …

This study looks at how long people with advanced chronic kidney disease should take two blood thinners (aspirin plus clopidogrel or prasugrel) after getting a heart stent. About 900 adults with severe kidney disease will be randomly assigned to either a short or long course of t…

This study tests whether a potassium-lowering drug (SZC) can help elderly patients (70+) with heart failure and chronic kidney disease safely increase their doses of RAASi medications, which are often limited by high potassium levels. About 94 participants will be randomly assign…

This study tests whether gentle shockwave therapy to the kidneys can help lower blood pressure and improve kidney function in people with chronic kidney disease and high blood pressure. 30 adults will receive either real or sham treatments over three weeks. The goal is to see if …

This study is testing a new imaging technique called dynamic full-field optical coherence tomography (OCT) to analyze kidney biopsy samples. The goal is to see if this method can quickly and accurately identify signs of acute kidney injury or chronic kidney disease, compared to t…

This study tests a special ultrasound technique called shear wave elastography to help doctors quickly tell if kidney disease is acute (new) or chronic (long-standing). The goal is to make diagnosis faster and safer for patients in the emergency room, avoiding the need for contra…

This study looks at whether a simple home-based walking program can help improve memory, thinking speed, and brain structure in older adults who have both chronic kidney disease and mild cognitive impairment. About 144 participants aged 55 and older will walk regularly for 6 mont…

This study tests whether a 12-week physical activity program can help teens with chronic kidney disease (CKD) become more active. Researchers will track exercise using a Fitbit and ask participants about their experience. The goal is to see if the program improves daily activity …

This study tests whether a 12-week high-velocity resistance training program is safe and doable for 30 older adults with advanced chronic kidney disease. Participants will either do the strength exercises or attend weekly healthy lifestyle group sessions. The goal is to see if th…

This study tests if a medicine called difelikefalin is safe for teenagers aged 12 to 17 who have severe itching due to kidney disease and are on dialysis. All 18 participants will receive the medicine during their regular dialysis visits for up to 12 weeks. The goal is to see if …

This study tests whether a small device that stimulates a nerve in the ear can safely help people with chronic kidney disease (stages 3-5) who have problems with their autonomic nervous system (which controls things like heart rate and blood pressure). Thirty participants will us…

This study tests a smartphone app that helps people with kidney disease manage body swelling by giving daily instructions on adjusting their water pill (diuretic) dose. Thirty participants will use the app for 90 days, entering their weight and blood pressure daily. The goal is t…

This study looks at 300 people with type 2 diabetes and high levels of protein in their urine to better understand diabetic kidney disease. Researchers will take small kidney samples and analyze blood, urine, and genetic data to find patterns that could improve diagnosis and pers…

This study looks at whether a single dose of equol, a substance made from soy, can improve blood vessel function in postmenopausal women. It includes women with and without chronic kidney disease (CKD). Researchers will measure changes in artery health over a few hours after taki…

This study looks at how blood pressure and artery stiffness change between day and night in 120 people at increased risk for heart disease, including those with kidney issues. Researchers want to understand who lacks the healthy nighttime blood pressure drop and whether taking me…

This study looks at how the sedative remimazolam works in 30 adults getting a kidney transplant. Researchers will measure drug levels in the blood and check how deeply patients are sedated. The goal is to learn how the drug behaves so it can be used more safely in future surgerie…

This study looks at how common chronic kidney disease is among adults being treated at a large hospital. Researchers will check 3,000 people over age 50 (or over 18 with conditions like diabetes or high blood pressure) to see how many have kidney disease and how many did not know…

This study looks at how social needs like food or housing affect self-care and health in African American adults with diabetic kidney disease. Researchers will talk with 330 participants to understand these challenges and design a culturally tailored program. The goal is to impro…

This study looks at a rare but serious condition called calciphylaxis, where small blood vessels in the skin harden, mainly in people with advanced kidney disease. Researchers will compare 860 adults with kidney disease—some who have calciphylaxis and some who don't—to find clues…

This study looks at simpler methods to measure how well the kidneys can handle extra work, known as renal reserve. Researchers will test 44 people with chronic kidney disease or those who have donated a kidney. Participants drink a protein shake, and their kidney function is chec…

This study looks at how common sleep apnea is in people with chronic kidney disease and whether it makes their kidney function worse over time. Researchers will follow 356 adults with moderate kidney disease for several years, tracking their health and any heart or kidney problem…

This study looks at whether adults with sudden illnesses like infections, heart failure, or asthma can be safely treated at home instead of in a hospital. Researchers will compare costs, patient experience, and health outcomes for 3,000 participants. The goal is to see if home ho…

This study looks at whether it's possible to run a larger trial of a drug called empagliflozin (a type of SGLT2 inhibitor) in 40 children and teens with chronic kidney disease. Participants are randomly assigned to take the drug or continue usual care for 3 months. The goal is to…

This study is looking at why some people with chronic kidney disease (CKD) lose muscle mass and strength, a condition called sarcopenia. Researchers will follow 1000 adults with CKD to find risk factors for sarcopenia and see how it affects their health over time. The goal is to …

This study is testing a smartphone app designed to help older adults (55+) with conditions like heart failure, diabetes, and kidney disease after they leave the hospital. The app provides fall prevention tips, a personalized care plan, and a way to track symptoms and questions fo…

This study aims to better understand acute kidney injury and chronic kidney disease by analyzing kidney tissue from 1,000 participants. Researchers will use advanced techniques to identify different disease subtypes and find new targets for treatments. The goal is to pave the way…

This study looks at how the eyes, brain, and kidneys affect each other in adults with chronic kidney disease (CKD). Researchers will use non-invasive MRI scans and eye imaging to see if changes in the brain and retina are linked to thinking problems and kidney function. About 1,5…

This study follows 300 babies born early (preterm) and at full term to understand how early birth affects kidney and heart health later in life. Researchers use ultrasound and blood/urine tests to spot early warning signs of kidney disease and high blood pressure. The goal is to …

This study is looking at 5,000 adults with or at risk for kidney disease, including transplant recipients, to find molecular clues that predict disease progression or complications. Researchers will analyze blood and urine samples using advanced techniques to identify genes, prot…

This study looks at whether doing handgrip exercises at home for 8 weeks can help lower blood pressure in people with chronic kidney disease (stages 3 and 4). About 50 adults aged 45-85 who do not exercise regularly will take part. Researchers will measure blood pressure, artery …

This study looks at how chronic kidney disease weakens the immune system, specifically T-cells, in 100 patients. Researchers will analyze blood samples to understand the immune defects. They will also test a new method in the lab to engineer T-cells using mRNA, aiming to restore …

This study follows 200 adults with advanced chronic kidney disease as they start dialysis at home or in a center. Researchers will track changes in quality of life, frailty, fatigue, and mood every 3 months for a year. The goal is to see if home dialysis helps patients stay healt…

This study looks at how dapagliflozin, a drug used for diabetes, affects heart and lung function in people with chronic kidney disease. Researchers will measure heart strain, oxygen use during exercise, and blood chemicals. The goal is to understand how the drug works, not to cur…