CHRONIC KIDNEY DISEASES

This study tested whether a low dose of the blood thinner rivaroxaban could reduce the risk of major heart problems (like heart attack or stroke) in people with advanced chronic kidney disease or kidney failure on dialysis. About 1,753 participants were randomly assigned to recei…

This study tested an experimental drug called KBP-5074 in 162 people with moderate-to-severe chronic kidney disease whose high blood pressure was not well controlled. The goal was to see if the drug could safely lower blood pressure and reduce kidney damage. Participants were ran…

This early-stage study tested an investigational drug called DISC-0974 in 55 adults with chronic kidney disease (not on dialysis) who also have anemia. The main goal was to check the drug's safety and how the body processes it. Researchers measured side effects, blood iron levels…

This study looked at whether community health workers can help low-income adults better manage chronic diseases like diabetes, high blood pressure, and obesity. About 200 people took part over 10 months. The goal was to see if working with a health worker improved health markers …

This study tested a treatment called REACT (rilparencel) for people with type 1 or 2 diabetes who also have chronic kidney disease. The treatment uses a person's own kidney cells to try to slow down kidney damage. 53 adults took part, and the study looked at safety and whether it…

This study looked at whether giving hospital-level care to acutely ill adults in their own homes in rural areas works well. 160 people with various conditions like infections, heart failure, or COPD took part. The main goal was to see if this approach could lower costs and keep p…

This study looked at whether special programs can help people with chronic kidney disease get kidney transplants earlier and reduce racial differences in care. Over 1,100 adults took part. The programs included a system to find patients who might need a transplant early and a tea…

This study tested whether people with type 2 diabetes and early kidney disease can manage their medications from home. Twelve participants took empagliflozin and, if needed, added finerenone to lower protein in their urine. They measured their own blood pressure, weight, and coll…

This study tested whether dapagliflozin, a diabetes drug, can reduce protein in the urine (a sign of kidney damage) in 55 kidney transplant patients with chronic kidney disease. Participants took the drug for 6 months, and researchers measured changes in protein levels and kidney…

This study tested a device called the everlinQ System in 32 adults with kidney failure who need hemodialysis. The device creates a connection between a vein and artery in the arm to allow easy blood flow for dialysis. The main goals were to see if the connection matures properly …

This study looked at whether an educational worksheet plus health coaching could help people with chronic kidney disease and high blood pressure improve their blood pressure. About 320 adults with moderate to severe kidney disease took part. The goal was to see if this approach l…

This study tested a new device that creates a connection between an artery and vein using a needle instead of surgery, making dialysis access easier. It involved 24 adults with kidney failure who needed dialysis. The goal was to see if the device could successfully create this ac…

This study tested a new dialysis filter called ELISIO-HX in 22 adults with kidney failure. The main goal was to see if the filter was safe by checking that it did not lower blood albumin levels. The study also looked at how well the filter removed certain waste products from the …

This study tested three doses of a monthly injection called Ziltivekimab in 264 adults with advanced chronic kidney disease and high inflammation. The goal was to see which dose best lowers inflammation markers, like hs-CRP, to help plan a larger trial on heart risks. Participant…

This study tested a drug called TOUR006 in 143 adults with chronic kidney disease and high levels of a blood marker for inflammation (hs-CRP). The goal was to see if monthly or quarterly injections could safely lower inflammation, which is linked to worse kidney outcomes. The stu…

This study tested a digital program called DDEP that helps people with chronic kidney disease and their care partners make healthy lifestyle changes. Over six months, 208 participants either received the program plus usual care or usual care alone. The goal was to see if the prog…

This study looked at whether adding empagliflozin (a diabetes drug) to standard water pills helps people with acute heart failure and moderate-to-severe kidney disease urinate out more excess fluid. 25 adults participated, and researchers measured urine output after combining the…

This small pilot study tested a cognitive behavioral program to help reduce fatigue in people with chronic kidney disease (CKD). Five adults with moderate-to-severe CKD joined remote sessions to learn strategies for managing tiredness. The main goal was to see if the program was …

This study looked at how dapagliflozin, a drug already used for kidney disease, changes the gut bacteria in people with chronic kidney disease who do not have diabetes. Researchers measured gut bacteria diversity and related toxins in the blood before and after 12 weeks of treatm…

This study looked at how sex hormones, especially estrogen, affect blood vessel function in women with chronic kidney disease (CKD). Researchers compared pre- and post-menopausal women with CKD to healthy women of the same age. The goal was to understand why women with CKD have h…

This study tested whether using a more accurate blood pressure reading (central aortic pressure) instead of the usual arm cuff helps manage blood pressure better in people with advanced chronic kidney disease. 116 adults with kidney failure risk were randomly assigned to either t…

This study looked at 76 adults with end-stage kidney disease to see if special ultrasound tests could predict whether a surgically created blood vessel connection (arteriovenous fistula) would work well for dialysis. The researchers measured artery stiffness and blood vessel func…

This study tested a program that helps low-income African Americans with diabetic kidney disease get their basic needs met, like food or housing. 50 people took part to see if the program was practical and could improve blood sugar, blood pressure, and quality of life. The goal w…

This study looked at how well primary care doctors referred patients with chronic kidney disease to kidney specialists. Researchers checked if referrals happened quickly enough and if patients were on the right treatment. The study involved 345 adults and used medical records fro…

This study tested whether sending digital letters to patients with chronic kidney disease and their general practitioners could increase the use of recommended medications. Over 28,000 adults in Denmark took part. The letters reminded them about updated treatment guidelines. The …

This study examined how the COVID-19 pandemic affected primary care for people with chronic conditions like diabetes, heart failure, and depression in Canada. Researchers analyzed health records from nearly 920,000 adults to see changes in doctor visits, tests, and treatments. Th…

This study looked at data from 372 patients who were part of a home hospital program. Researchers used a computer program (machine learning) to see if it could predict which patients would need to be readmitted to the hospital within 30 days. The goal was to learn if this approac…

This study tested whether community health workers and trauma-informed care training for doctors can improve quality of life for Black and Hispanic patients with advanced chronic kidney disease. 153 patients from high-poverty areas in Philadelphia took part. The goal was to see i…

This completed study used advanced MRI scans to look at heart structure and function in 276 adults with chronic kidney disease (stages 3-5). The goal was to identify different types of heart damage linked to kidney failure and dialysis, and to see which patterns lead to worse out…

This study tested whether a computer alert in the medical record system could prompt doctors to order a simple urine test for kidney disease in people with type 2 diabetes. Many patients with diabetes have early kidney damage but don't know it. The study involved 400 adults at on…

This study tested an electronic alert system that reminds general practitioners to screen and manage chronic kidney disease (CKD) in at-risk patients. The trial involved 65 primary care centers in Stockholm, Sweden, and used existing health records to measure whether the alerts i…

This study tested a program to improve conversations between older adults (65+) with advanced kidney disease and their kidney doctors about whether to start dialysis. The program trained doctors in communication skills and coached patients to share their values and ask key questi…

This study looked at whether a computer program could predict when patients being treated at home might suddenly get worse. Researchers used data from 526 patients to train and test the program. The goal was to see if the program could alert doctors early, helping prevent serious…

This study looked back at medical records of 490 people with liver cirrhosis and kidney problems to see how well a treatment (terlipressin and albumin) worked. The goal was to compare treatment response in patients with and without chronic kidney disease. The study is complete an…

This study tested whether 3D ultrasound can accurately measure kidney and tumor volumes, comparing it to standard CT or MRI scans. 53 adults with chronic kidney disease or renal tumors participated. The goal was to see if this simpler, radiation-free method could be a reliable al…

This completed study examined 88 Afro-Caribbean adults in Guadeloupe to understand how a specific gene (APOL1) and other health factors like diabetes and high blood pressure relate to advanced chronic kidney disease (stage 4). Researchers analyzed DNA from blood samples to identi…

This study aimed to create a tool that helps doctors decide which patients with severe acute kidney injury should see a kidney specialist after leaving the hospital. Researchers looked at 319 patients who needed dialysis for kidney injury and tracked their recovery. The goal was …