Kidney disease and Women's heart risk: hormones may hold the key

NCT ID NCT05471518

Completed Knowledge-focused Sponsor: University of Colorado, Denver Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026 · Updated 1 time

Summary

This study looked at how sex hormones, especially estradiol, affect blood vessel function in women with chronic kidney disease (CKD). Researchers compared pre- and post-menopausal women with CKD to healthy women of the same age. They measured blood vessel dilation and stiffness, along with hormone levels, to understand why women with CKD face higher heart disease risk. The goal is to uncover whether hormone changes from CKD contribute to blood vessel damage.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this research could help explain why women with CKD have higher heart disease risk and point toward hormone-based treatments to protect their blood vessels.
What could go wrong: This is a small, completed observational study (51 participants) that only measures associations, not causes. The findings may not apply to all women with CKD or lead directly to treatments.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

chronic kidney disease chronic renal failure syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHRONIC KIDNEY DISEASES

Contacts and locations

Locations

University of Colorado Anschutz Medical Campus

Aurora, Colorado, 80045, United States

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