Prebiotic fiber and exercise may ease inflammation in kidney patients

NCT ID NCT03689569

Completed Disease control Sponsor: Springfield College Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at whether taking a prebiotic fiber (resistant starch) and doing moderate aerobic exercise for 16 weeks could reduce inflammation and improve blood vessel health, thinking, and mood in people with stage 3-4 chronic kidney disease. 68 patients were randomly assigned to receive the prebiotic or a placebo, with some also exercising. The goal was to see if these lifestyle changes could help manage the disease before dialysis is needed.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: resistant starch (a type of prebiotic fiber)
What this could lead to: If it works, this could point toward a simple, non-drug way to manage inflammation and slow kidney disease progression.
What could go wrong: This is a small, early-stage study with only 68 participants. Results may not apply to everyone, and the benefits of prebiotics and exercise may be modest or hard to separate from other factors.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

chronic kidney disease chronic renal failure syndrome Inflammation

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHRONIC KIDNEY DISEASES

Contacts and locations

Locations

Springfield College

Springfield, Massachusetts, 01109, United States

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