Can a tiny dose of a common blood thinner protect hearts in kidney failure?

NCT ID NCT03969953

Completed Disease control Sponsor: The George Institute Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether a low dose of the blood thinner rivaroxaban (Xarelto) could reduce major heart problems like heart attacks and strokes in people with advanced chronic kidney disease or kidney failure on dialysis. About 1,753 participants were randomly assigned to receive either the drug or a placebo. The goal was to see if the drug lowers the risk of cardiovascular death, heart attack, stroke, or serious artery disease without causing excessive bleeding.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Rivaroxaban (Xarelto) low-dose tablet
What this could lead to: If successful, this could offer a way to lower the risk of heart attacks, strokes, and related deaths in people with advanced kidney disease who currently have few safe options.
What could go wrong: This is a completed Phase 3 trial, but results are not yet published. The drug may not reduce heart risks in this group, and bleeding is a known risk of blood thinners like rivaroxaban.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

cardiovascular disorder chronic kidney disease chronic renal failure syndrome end stage renal failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CARDIOVASCULAR DISEASE CHRONIC KIDNEY DISEASES DIALYSIS-DEPENDENT KIDNEY FAILURE

Contacts and locations

Locations

AIIMS Bhubaneswar

Bhubaneswar, India
AURAL Colmar, (AURAL Colmar)

Colmar, 68000, France
AURAL Haguenau, (AURAL Haguenau)

Haguenau, 67500, France
AURAL Mulhouse, (AURAL Mulhouse)

Mulhouse, 68100, France
AURAL Strasbourg, (AURAL Strasbourg)

Strasbourg, 67000, France
AZ Sint-Jan Brugge

Bruges, Belgium
All India Institute Of Medical Sciences, Raipur

Raipur, Chhattisgarh, 700020, India
All India Institute of Medical Sciences, Bathinda

Bathinda, Punjab, 151001, India
Apollo Hospital

Chennai, Tamil Nadu, India
Asian Institute of Nephrology and Urology

Hyderabad, India
Aykai Super Speciality Hospital, Ludhiana

Ludhiana, Punjab, 141010, India
Aysha Hospital

Chennai, Tamil Nadu, 600010, India
Bendigo Health

Bendigo, Victoria, 3552, Australia
CH Boulogne-sur-Mer, (CH Boulogne-sur-Mer)

Boulogne-sur-Mer, 62200, France
CH Haguenau, (CH Haguenau)

Haguenau, 67500, France
CH Le Puy-en-Velay

Le Puy-en-Velay, France
CH Mulhouse, (CH Mulhouse)

Mulhouse, 68100, France
Canberra Hospital

Garran, Australian Capital Territory, 2605, Australia
Centre Hospitalier Régional Universitaire de Nancy

Nancy, Meurthe-et-Moselle, 54035, France
Chang Gung Memorial Hospital, Linkou Medical Center

Taoyuan, 333, Taiwan
Charles Nicolle Hospital

Tunis, Tunisia
Chung-Shan Medical University Hospital

Taichung, 402, Taiwan
Citizens Hospital

Hyderabad, Telangana, 500019, India
Concord Repatriation General Hospital

Concord, New South Wales, 2139, Australia
Dialysis Centre - King Abdul Aziz Medical City (KAMC)

Ar Rimāyah, Riyadh Region, 11481, Saudi Arabia
Fattouma Bourguiba Hospital

Monastir, Tunisia
Fu-Jen Catholic University Hospital

Taishan, New Taipei City, 243, Taiwan
Government Hospital

Nandyāl, 518501, India
Government Hospital

Proddatūr, 516362, India
Hedi chaker Hospital

Sfax, Tunisia
Hemodialysis Care Project North Centre

Al Yāsamīn, Riyadh Region, 13322, Saudi Arabia
Hemodialysis Care Project South Centre

Riyadh, Riyadh Region, 12799-6176, Saudi Arabia
Hemodialysis King Abdullah Centre

Al Yāsamīn, Riyadh Region, 13322, Saudi Arabia
Hopital Louis Pasteur (CH Colmar)

Colmar, France
Hospital Ampang

Ampang, Malaysia
Hospital Canselor Tuanku Muhriz

Kuala Lumpur, Kuala Lumpur, 56000, Malaysia
Hospital Kajang

Kajang, Selangor, 43000, Malaysia
Hospital Pakar Sultanah Fatimah Muar

Muar town, Malaysia
Hospital Queen Elizabeth, Kota Kinabalu

Kota Kinabalu, Sabah, 88200, Malaysia
Hospital Raja Perempuan Zainab II

Kota Bharu, Kelantan, 15586, Malaysia
Hospital Raja Permaisuri Bainun, Ipoh

Ipoh, Perak, 30450, Malaysia
Hospital Seberang Jaya

Seberang Jaya, Pulau Pinang, 13700, Malaysia
Hospital Sultanah Bahiyah

Alor Star, Kedah, 05460, Malaysia
Hospital Tuanku Ja'afar, Seremban

Seremban, Negeri Sembilan, 70300, Malaysia
Hôpital Bretonneau, (CHRU Tours)

Tours, 37000, France
Hôpital Edouard Herriot, (CHU Lyon)

Lyon, 69003, France
Hôpital Pasteur, (CHU Nice)

Nice, 06000, France
Hôpital de la Cavale Blanche, (CHU Brest)

Brest, 29200, France
Hôpital de la Conception, (AP-HM)

Marseille, 13005, France
Hôpital de la Maison Blanche, (CHU Reims)

Reims, 51092, France
Hôpitaux de Brbaois, (ALTIR)

Vandœuvre-lès-Nancy, 54500, France
Institute of Post-Graduate Medical Education and Research

Kolkata, 700020, India
KG Hospital, K.Govindaswamy Naidu Medical Trust

Coimbatore, 641018, India
KRH Klinikum Siloah

Hanover, Germany
Kaohsiung Chang-Gung Memorial Hospital

Kaohsiung City, 833, Taiwan
Kaohsiung Medical University Chung-Ho Memorial Hospital

Kaohsiung City, 807, Taiwan
Khoo Teck Puat Hospital

Singapore, 767828, Singapore
King Abdulaziz Medical City - Western Region - Jeddah, Ministry of National Guard - Health Affairs

Jeddah, Saudi Arabia
King Saud University Medical City (KSUMC)

Riyadh, Saudi Arabia
La Rabta Hospital

Tunis, Tunisia
Logan Hospital

Meadowbrook, Queensland, 4131, Australia
Military Hospital

Tunis, Tunisia
Mongi Slim Hospital

Tunis, Tunisia
Muljibhai Patel Urological Hospital

Nadiād, Gujarat, 387001, India
Nepean Hospital

Kingswood, New South Wales, 2747, Australia
Nil Ratan Sircar Medical College and Hospital

Kolkata, India
Nizam's Institute of Medical Sciences, Hyderabad

Hyderabad, Telangana, 500082, India
Noble Annex Hospital

Hadapsar, Pune Maharashtra, 411013, India
Nutema Hospital

Meerut, Uttar Pradesh, India
Osmania General Hospital

Hyderabad, Telangana, 500012, India
Postgraduate Institute of Medical Education and Research, Chandigarh

Chandigarh, 160012, India
Prince of Wales Hospital

Randwick, New South Wales, 2031, Australia
Research St. Joseph's - Hamilton

Hamilton, Canada
Royal Adelaide Hospital

Adelaide, South Australia, 5000, Australia
Royal North Shore Hospital

St Leonards, New South Wales, 2065, Australia
Safdarjung Hospital

New Delhi, India
Sahloul Hospital

Sousse, Tunisia
St George Hospital

Kogarah, New South Wales, 2217, Australia
Sunshine Hospital

St Albans, Victoria, 3021, Australia
Taher Sfar Hospital

Tunis, Tunisia
Taipei Tzu Chi Hospital

Taipei, 231, Taiwan
Tan Tock Seng Hospital

Singapore, 308433, Singapore
Tribhuvan University College

Kathmandu, Nepal
University of Alberta

Edmonton, Canada
University of Malaya Medical Centre

Kuala Lumpur, Kuala Lumpur, 59100, Malaysia
VS Hospital

Kilpauk, 600010, India
Wan fang Hospital

Taipei, 116, Taiwan
Wollongong Hospital

Wollongong, New South Wales, 2500, Australia

More trials for these conditions

Other studies related to the condition(s) this trial covers.