CHRONIC KIDNEY DISEASES

This study tests whether a natural compound called fisetin can reduce inflammation and improve stem cell function in 30 adults with advanced chronic kidney disease, including those with diabetes. Participants will take fisetin or a placebo for 14 days, and researchers will measur…

This early-phase study tests whether the drug belumosudil can help people who receive a kidney transplant along with a stem cell transplant from the same donor. The goal is to see if it is safe and allows patients to stop taking most anti-rejection drugs over time. The study invo…

This study tests a health behavior change program for 160 adults with both metabolic syndrome and chronic kidney disease. The program aims to reduce waist size and improve kidney function through better diet and physical activity. Participants are followed for one month after the…

This study tests a procedure called renal denervation, which uses a device to calm overactive nerves in the kidneys that can raise blood pressure. About 1,900 adults with uncontrolled high blood pressure will be followed for years to see if the treatment safely and durably lowers…

This study is testing whether home-delivered fruits and vegetables can be a practical alternative to medication for managing acid buildup in people with chronic kidney disease. It's a small, early-stage trial with 37 participants, focusing on whether this dietary approach is feas…

This study tests a new ultrasound method that uses a contrast agent to create detailed images of blood vessels in the kidneys. Researchers want to see if this can help diagnose chronic kidney disease more accurately. The study includes both healthy volunteers and people with kidn…

This study is testing a virtual health platform called GoodRENal.eu for people with end-stage kidney disease who are on hemodialysis. The program combines exercise, nutrition advice, and psychological support to help patients feel better and improve their daily lives. About 70 pa…

This study gathers information on a new dialysis machine (CARPEDIEM) designed specifically for critically ill infants with kidney failure. Researchers will track up to 1,000 babies across the U.S. to learn the best ways to use the machine, how well it works, and whether it helps …

This study is building a registry of 5000 adults with chronic kidney disease (CKD) to collect information on their health, treatments, and outcomes. The goal is to understand how CKD progresses, identify risk factors, and see how well current care matches guidelines. Participants…

This study is collecting health and genetic information from 120,000 people with chronic diseases like pancreatitis, inflammatory bowel disease, diabetes, and arthritis. Researchers want to understand how genes, lifestyle, and other factors affect disease progression and quality …

This study looks at how two drugs, Sacubitril/Valsartan (Entresto) and MANP, affect people with a type of heart failure called HFpEF, which also involves chronic kidney disease or shortness of breath during exercise. Researchers will measure changes in body fluids and certain che…

This study follows about 793 people with chronic kidney disease who already took part in a program to help them get kidney transplants. Researchers want to see if the program's effects last, like whether patients talk to doctors and family about transplants or find living donors.…

This study looked at using a computer program (machine learning) to predict how long patients would stay in a home hospital. Researchers used information from past patients, like their health conditions and background, to train the computer model. The goal was to see if the model…

This study follows 600 people with and without chronic kidney disease (CKD) for up to 4 years to see how memory, thinking, and daily activities change over time. Researchers will compare the two groups and look for risk factors that may lead to cognitive decline, dementia, or str…

This study planned to use a computer program (machine learning) and a simple heart test (single-lead ECG) to predict potassium levels in the blood of hospitalized patients. Researchers would have analyzed data from a previous study at Brigham and Women's Hospital. However, the st…

This study screened over 16,600 adults in Spain (ages 45-70) with at least one risk factor (like high blood pressure or smoking) but no known heart disease. Half received advanced ultrasound and urine tests to find hidden artery and kidney problems. The goal is to see if early de…

This study looks at adding geriatric care to dialysis clinics for patients aged 55 and older. The goal is to better manage common problems like depression, memory issues, and falls. About 120 participants will be involved to see if this approach is practical and helpful.

This study tests a new educational tool to help people with chronic kidney disease (CKD) make informed decisions about pregnancy and contraception. About 70 participants will use the tool and then answer a survey to see how prepared they feel to make those decisions. The goal is …

This study uses a special MRI technique called T1 mapping to measure changes in heart muscle tissue. Researchers will follow 8,000 adults who are already having a heart MRI to see if these measurements can help predict future health problems like heart failure or death. The goal …

This study looks at muscle and fat in people with chronic kidney disease (CKD) compared to healthy volunteers. The goal is to understand when and how muscle loss happens in CKD, so future treatments can improve quality of life. About 80 adults with and without CKD will take part.

This study was designed to see if using digital tools and body composition monitors could better predict how much fluid is removed during automated peritoneal dialysis. It planned to enroll adults with chronic kidney disease on dialysis for at least 3 months. However, the study w…

This study looks at whether a video-based learning program (KidneyTIME) helps people with kidney failure learn more about getting a kidney from a living donor and take action to find one. About 422 adults who are being evaluated for a kidney transplant will either get the video p…