Could a simple ultrasound replace kidney biopsies?
NCT ID NCT05764642
First seen Oct 31, 2025 · Last updated Jun 22, 2026 · Updated 28 times
Summary
This study tests a new ultrasound technique that uses tiny bubbles to create detailed images of blood vessels in the kidney. Researchers hope this can help diagnose chronic kidney disease without an invasive biopsy. The study involves 186 healthy volunteers and kidney disease patients at Mayo Clinic.
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Mayo Clinic Florida
Jacksonville, Florida, 32224, United States
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Mayo Clinic Minnesota
Rochester, Minnesota, 55905, United States
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Definity (ultrasound contrast agent)
What this could lead to
If successful, this could provide a non-invasive way to diagnose and monitor chronic kidney disease, reducing the need for biopsies.
What could go wrong
This is an early-phase study with only 186 participants, so results may not apply to everyone. The imaging technique is still experimental and may not be accurate enough for routine use.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.