New drug combo tested for stubborn heart failure

This study looks at how two drugs, Sacubitril/Valsartan (Entresto) and MANP, affect people with a type of heart failure called HFpEF, which also involves chronic kidney disease or shortness of breath during exercise. Researchers will measure changes in body chemicals and kidney function after giving the drugs or a placebo. The goal is to understand how these drugs work in different patient groups, not to cure the condition.