Could an antibody tame inflammation in kidney patients?

NCT ID NCT03926117

Completed Disease control Sponsor: Novo Nordisk A/S Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested a drug called ziltivekimab in 264 people with advanced chronic kidney disease and high inflammation. Participants received monthly injections of either a placebo or one of three doses of ziltivekimab for six months. The goal was to see if the drug could safely lower inflammation markers, which might reduce the risk of heart problems in these patients.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: ziltivekimab (an antibody that blocks IL-6, a protein involved in inflammation)
What this could lead to: If successful, this could lead to a new treatment to lower inflammation and potentially reduce heart problems in people with advanced kidney disease.
What could go wrong: This is an early-phase trial with only 264 participants, so results may not apply to everyone. The drug may not work as hoped or could cause side effects like infections.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

cardiovascular disorder chronic kidney disease chronic renal failure syndrome Inflammation inflammatory disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHRONIC KIDNEY DISEASES INFLAMMATION

Contacts and locations

Locations

AMPM Research Clinic

Miami, Florida, 33169, United States
Apex Research of Riverside

Riverside, California, 92505, United States
Arizona Kidney Disease and Hypertension Center

Phoenix, Arizona, 85016, United States
Aventiv Research

Mesa, Arizona, 85210, United States
Biopharma Informatick Inc. Research Center

Houston, Texas, 77043, United States
Capital Nephrology

Greenbelt, Maryland, 20770, United States
Central Alabama Research

Birmingham, Alabama, 35205, United States
Clinical Advancement Center, PLLC

San Antonio, Texas, 78212, United States
Clinical Investigation Specialist, Inc

Kenosha, Wisconsin, 53142, United States
Clinical Trials of America, LLC - West Monroe

Monroe, Louisiana, 71201, United States
Columbus Regional Research Institute

Columbus, Georgia, 31904, United States
DaVita Clinical Research

Minneapolis, Minnesota, 55404, United States
DaVita Clinical Research

The Bronx, New York, 10461, United States
Elite Clinical Studies

Phoenix, Arizona, 85018, United States
Florida Premier Research Institue, LLC

Winter Park, Florida, 32789, United States
Henry Ford Health System

Detroit, Michigan, 48202, United States
Investigator Research by Design, LLC

Chicago, Illinois, 60643, United States
Julia and Israel Waldbaum Dialysis Center

Great Neck, New York, 11021, United States
Juno Research, LLC - Northwest

Houston, Texas, 77070, United States
Knoxville Kidney Center, PLLC

Knoxville, Tennessee, 37923, United States
Manassas Clinical Research Center

Manassas, Virginia, 20110, United States
Metrolina Nephrology Associates

Charlotte, North Carolina, 28277, United States
Metrolina Nephrology Associates, PA

Charlotte, North Carolina, 28207, United States
Mountain Kidney and Hypertension Associates

Asheville, North Carolina, 28801, United States
Mountain View CLinical Research - Greer

Greer, South Carolina, 29651, United States
Nephrology Associates, PC

Nashville, Tennessee, 37205, United States
Nephrology Research of Michigan

Saint Clair Shores, Michigan, 48081, United States
North America Research Institute

Lynwood, California, 90262, United States
North America Research Institute

Riverside, California, 92503, United States
North America Research Institute

San Dimas, California, 91773, United States
North Hills Medical Research, Inc

North Richland Hills, Texas, 76180, United States
Northeast Clinical Research Center

Allentown, Pennsylvania, 18104, United States
Northport VAMC

Northport, New York, 11768, United States
Ocala Cardiovascular Research

Ocala, Florida, 34474, United States
Onyx Clinical Research

Caro, Michigan, 48723, United States
Piedmont Research Partners, LLC

Fort Mill, South Carolina, 29707, United States
Renal Disease Research Institute

Dallas, Texas, 75246, United States
Rhode Island Hospital

Providence, Rhode Island, 02903, United States
San Antonio Kidney Disease Center Physicians Group, PLLC

San Antonio, Texas, 78229, United States
Southeastern Clinical Research Institute, LLC

Augusta, Georgia, 30901, United States
Southeastern Nephrology - Whiteville

Whiteville, North Carolina, 28472, United States
Southeastern Nephrology Associates - Wilmington

Wilmington, North Carolina, 28401, United States
Southside Urology and Nephrology

Danville, Virginia, 25241, United States
St. Clair Nephrology Research

Roseville, Michigan, 48066, United States
Summit Research Group, LLC

Stow, Ohio, 44224, United States
University of Iowa

Iowa City, Iowa, 52242, United States
University of Vermont

Burlington, Vermont, 05401, United States
Vilo Research Group, Inc

Houston, Texas, 77017, United States
Western Nephrology and Metabolic Bone Disease, PC

Arvada, Colorado, 80002, United States

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