A drug and exercise combo takes aim at the dangers of prolonged sitting in kidney disease

NCT ID NCT05173714

Recruiting now Disease control Sponsor: Srinvasan Beddhu Source: ClinicalTrials.gov ↗

First seen Jul 27, 2026 · Last updated Jul 28, 2026 · Updated 1 time

Summary

This study tests whether adding guided resistance training and the medication semaglutide can help people with chronic kidney disease stick to a program that replaces one hour of sitting per day with light walking. The goal is to reduce sedentary time, which is linked to worse kidney function and higher risks of diabetes and heart disease. Participants will be followed for a year to see if these additions improve adherence and increase daily steps.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: semaglutide and guided resistance training
What this could lead to: If successful, this approach could offer a practical way to reduce sedentary behavior and improve physical function in people with chronic kidney disease.
What could go wrong: This is a mid-stage trial, so results may not be definitive. Semaglutide can cause gastrointestinal side effects, and the behavioral intervention may not sustain long-term adherence.

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Conditions

The condition(s) this trial relates to.

chronic kidney disease chronic renal failure syndrome Obesity obesity disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHRONIC KIDNEY DISEASES OBESITY

Contacts and locations

Locations

Stanford University
RECRUITING

Stanford, California, 94305, United States
University of Utah
RECRUITING

Salt Lake City, Utah, 84108, United States

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