Chronic kidney disease

This trial tests a new cell therapy called TX200-TR101 in people who receive a kidney from a living donor. The therapy is made from the patient's own immune cells, which are genetically modified to help the body accept the donated kidney instead of rejecting it. The study focuses…

This study tests a single dose of ravulizumab given before heart surgery to see if it can prevent kidney damage and serious kidney problems in people with chronic kidney disease. About 736 adults will take part. The goal is to reduce the risk of major kidney events within 90 days…

This study tests whether a 3-month nurse-led program can reduce frailty and improve self-management in people undergoing peritoneal dialysis. The program includes personalized assessments, education, exercise training, and social support. Researchers compare this program to stand…

This study tested whether adding balcinrenone to the standard drug dapagliflozin helps people with chronic kidney disease more than dapagliflozin alone. 324 adults with kidney disease and protein in their urine took either a combination pill or dapagliflozin alone for 12 weeks. R…

This study looks at whether a new method of measuring parathyroid hormone (PTH) can help doctors better manage calcium and phosphate levels in people on hemodialysis. About 80 patients with end-stage kidney disease will be randomly assigned to have their PTH measured either with …

This completed Phase 4 trial tested two drugs—dapagliflozin and spironolactone—alone and together in 12 adults with Alport syndrome, a genetic kidney disease. The goal was to see if these drugs could lower protein levels in urine, a key sign of kidney damage. Participants took ea…

This early-phase study tested whether stem cells taken from a patient's own urine (called KDSTEM Inj.) are safe for people with chronic kidney disease. Six participants received low or high doses of the cells through an IV. The main goal was to check for side effects, while also …

This study tested whether taking two doses of sodium bicarbonate (baking soda) over 24 hours could reduce uric acid crystals in the urine of adults with type 1 diabetes. Uric acid crystals can harm the kidneys, so lowering them might help prevent diabetic kidney disease. The tria…

This study tested whether quickly alerting a kidney specialist team when hospitalized patients show signs of severe kidney disease could improve survival. Over 1,100 patients in France were included. The team of a nephrologist and pharmacist would help manage care during the hosp…

This study compares two dialysis filters, SOLACEA-H and HYDROLINK-NVU, to see if SOLACEA-H can allow dialysis sessions with less or no blood thinner (heparin). The trial involves 20 adults who have been on dialysis for at least 3 months and are medically stable. Each participant …

This study tested a new drug called BAY3283142 in 75 people with mild to moderate high blood pressure. The drug is designed to relax blood vessels and is being developed for chronic kidney disease. Participants took different doses or a placebo for up to 10 weeks to check for saf…

This completed study tested whether eating more fruits and vegetables or taking sodium bicarbonate (baking soda) tablets can slow the progression of chronic kidney disease and reduce heart risks in people with high blood pressure and kidney damage. 108 non-diabetic adults with st…

This study tested whether reducing dietary acid with fruits and vegetables or sodium bicarbonate (baking soda) can slow chronic kidney disease in people with high blood pressure. 153 participants were followed for 5 years to measure kidney function and heart risk markers. The goa…

This completed study tested whether adding AC-134, a dietary supplement, to a low-protein diet helps protect kidney function in people with chronic kidney disease. Researchers measured kidney function, protein in urine, and waste products in the blood of 100 adults aged 20-90 wit…

This study looked at whether a 24-week exercise program can improve physical fitness, muscle strength, and overall health in people who received a kidney transplant. 345 adults joined the study six months after their transplant. Researchers compared those who exercised with those…

This study tested two different combinations of immunosuppressant drugs in 88 adults who received a new kidney. The goal was to see which plan better protects kidney function over the short term. All participants took lifelong anti-rejection medication, so this is about managing …

This study tested whether face-to-face nutrition education about potassium could help people on maintenance hemodialysis control their potassium levels. Fifty adult patients with high potassium took part. The goal was to reduce complications and improve quality of life.

This study tested a drug called sacubitril/valsartan (a heart failure medication) in 45 adults who had just started hemodialysis. The goal was to see if it could improve heart function and help preserve any remaining kidney function compared to a placebo. Participants took the dr…

This phase 2 trial tested whether adding the experimental drug lorundrostat to standard SGLT2 inhibitor therapy can lower blood pressure in adults with chronic kidney disease and albuminuria (protein in urine). Sixty participants received either lorundrostat or a placebo for four…

This study looked at how well the Ellipsys Vascular Access System works for creating arteriovenous (AV) fistulas in people with end-stage kidney disease who need dialysis. A total of 142 patients were followed for 12 months to see how long the access stayed open and how safe the …

This study looked at whether a high-protein drink with added curcumin (a compound from turmeric) could lower inflammation and oxidative stress in adults on hemodialysis for advanced kidney disease. 39 participants were randomly assigned to receive either the curcumin drink or a p…

This study tested a plant-based tablet called PH3 in 100 adults with diabetic nephropathy (kidney damage from diabetes). The goal was to see if PH3 can safely reduce protein in the urine, a sign of kidney stress, over 24 weeks. Researchers also looked at the best dose to use in f…

This study tested whether a smart app called Weiyin Health could improve follow-up care for 223 adults on peritoneal dialysis for kidney failure. One group used the app for reminders, AI questions, and risk alerts, while the other got standard care via WeChat and phone calls. The…

This study tested a tailored lifestyle counseling program for 120 adults with early-stage chronic kidney disease (CKD). Participants received personalized advice based on their readiness to change, focusing on diet, exercise, and kidney health knowledge. The goal was to see if th…

This completed study tested an oral supplement made from generally recognized as safe (GRAS) ingredients in 8 people with end-stage kidney disease. Two participants had not produced urine for 16 and 22 years. The goal was to see if the supplement could restore even a small amount…

This study tested a device called VasQ that wraps around a surgically created blood vessel connection (fistula) used for dialysis in people with kidney failure. The device is designed to improve blood flow and reduce complications. 144 patients received the device and were follow…

This study tested whether the drug sacubitril/valsartan can improve heart function in people with heart failure who are on chronic hemodialysis. 52 patients were split into two groups: one received the drug, the other standard care. Researchers measured changes in heart ultrasoun…

This study tests a new drug called SHR6508 in 303 adults on hemodialysis who have secondary hyperparathyroidism, a condition where parathyroid hormone levels get too high. The drug is given as an injection to help control these hormone levels and related minerals like calcium and…

This study tested whether a daily supplement called Avmacol Extra Strength, which contains sulforaphane from broccoli seeds, can slow kidney disease progression in people with stage 3 or 4 chronic kidney disease. The trial enrolled 96 adults and compared the supplement to a place…

This study tested whether a class of diabetes drugs called SGLT2 inhibitors can slow the progression of kidney disease in adolescents with type 1 diabetes. Researchers measured changes in urine protein levels and blood sugar control over 6 months in 86 participants aged 10-18. Th…

This study tested whether using sevoflurane gas for anesthesia during kidney transplant surgery helps the new kidney recover faster than standard propofol anesthesia. 120 adults receiving a kidney transplant were randomly assigned to one of the two anesthetics. Researchers tracke…

This study compared two types of dialysis in 415 older adults (ages 65-90) with chronic kidney failure: online hemodiafiltration and conventional hemodialysis. The goal was to see which method is better tolerated and whether it reduces heart problems and other complications. Pati…

This completed study tested whether lotus seed capsules could improve nerve health, blood sugar, and immune function in 60 people with type 2 diabetes and nerve damage. Participants took either lotus seed or placebo capsules for 9 months alongside their regular diabetes treatment…

This study tested whether resveratrol, a natural substance found in grapes and peanuts, could improve blood sugar control and kidney health in 60 teenagers with type 1 diabetes and early kidney damage. Participants took resveratrol tablets twice daily for 6 months. The study meas…

This study looked at whether adding citrate to the fluid used during dialysis can slow the buildup of calcium in blood vessels. 54 adults on hemodialysis who already had some vessel hardening took part. Each person used a standard fluid for 12 months and a citrate fluid for anoth…

This study tested an experimental drug, ziltivekimab, in 36 adults with advanced chronic kidney disease (not on dialysis) to see if it can safely reduce inflammation and related heart risks. Participants received either a low dose, a high dose, or a placebo injection every 4 week…

This study tested a drug called imlifidase in 113 highly sensitized kidney patients who had a positive crossmatch against a deceased donor. The drug was given before transplant to reduce the risk of rejection. The main goal was to see how many patients still had a working kidney …

This phase 2 trial tested a new combination of drugs—siplizumab, belatacept, and mycophenolic acid—in 76 people who just received a kidney transplant. The goal was to see if this combo is safer and works better than the usual immunosuppression therapy. Researchers measured side e…

This study tested a device that uses ultrasound to calm overactive nerves in the kidneys, which can drive high blood pressure. Researchers enrolled 44 people with stage 3 chronic kidney disease and uncontrolled hypertension. Half received the real procedure, half a sham, to see i…

This phase 3 trial tested a drug called imlifidase in 64 highly sensitized kidney transplant patients who had almost no chance of finding a compatible donor. The drug breaks down harmful antibodies, allowing a transplant from a donor that would normally be rejected. The study mea…

This study compared two types of home dialysis for people with end-stage kidney disease: nighttime automated dialysis (APD) and daytime manual dialysis (CAPD). 137 non-diabetic adults tried each method for 12 weeks. The goal was to see if nighttime dialysis was as good as daytime…

This study tested whether a drug called Lokelma (SZC) can help people with both chronic kidney disease and heart failure safely reach higher doses of life-saving heart medications (RAAS inhibitors) without dangerous potassium spikes. 112 adults with stable kidney disease and hear…

This study looked at whether a 12-week program of exercise, a protein-controlled diet, and education could improve health in people with early-stage kidney disease (stages G1 and G2). Fifteen participants completed the program. Researchers measured changes in cholesterol, muscle …

This study tested whether a form of vitamin B6 called pyridoxamine can improve the health of small blood vessels in people with type 2 diabetes. The researchers gave 40 participants either pyridoxamine or a placebo for a period, then switched treatments to compare effects. They m…

This study tested two flavors of a high-energy, low-protein drink called Renalive® LP in 74 adults with chronic kidney disease stages 3b-5. Participants drank the formula as a meal replacement or supplement for 4 weeks. The goal was to see if the drink was suitable and helped mai…

This study looked at whether taking a prebiotic fiber (resistant starch) and doing moderate aerobic exercise for 16 weeks could reduce inflammation and improve blood vessel health, thinking, and mood in people with stage 3-4 chronic kidney disease. 68 patients were randomly assig…

This study tested whether a 6-month program of plant-based diet, home exercise, medication management, and behavioral counseling could improve physical function in 42 adults with stage 3-4 chronic kidney disease. Participants were randomly assigned to the lifestyle program or usu…

This study tested whether baricitinib, a drug used for arthritis, can safely reduce high protein levels in the urine of African American adults with a specific genetic form of kidney disease (APOL1). Eight participants took the drug to see if it lowered their urine protein and pr…

This study tested a new drug called DISC-0974 in 55 adults with chronic kidney disease (not on dialysis) who also have anemia. The goal was to check the drug's safety and how the body processes it. Participants received either the drug or a placebo by injection. The results will …

This study tested a once-daily pill called orforglipron against insulin glargine in nearly 2,750 adults with type 2 diabetes, obesity or overweight, and increased cardiovascular risk. The main goal was to see if orforglipron could reduce major heart events like heart attacks or s…

This study compared two types of IV fluids given to kidney transplant patients during their first week after surgery. The goal was to see which fluid better prevents electrolyte imbalances and helps the new kidney work well. About 159 adult patients who received a kidney from a l…

This pilot study tested whether giving produce vouchers to 100 adults with chronic kidney disease and food insecurity could improve their health. Participants received $40-$60 in vouchers every two weeks for six months. Researchers measured changes in food security, diet quality,…

This study tested whether taking probiotics or synbiotics (probiotics plus fiber) for 6 months could improve health in 60 adults with kidney failure on dialysis. Researchers measured changes in blood toxins, heart health, quality of life, and thinking ability. The goal was to see…

This study tested a special dialysis fluid called icodextrin in 439 adults with chronic kidney failure who use peritoneal dialysis at home. The goal was to see if it works better than standard glucose solutions for overnight exchanges and to check for side effects. Researchers tr…

This study looked at how a tacrolimus tablet (TacroBell) works in people who received a kidney transplant. The goal was to measure drug levels in the blood and see how well patients tolerated it. 128 adults who were getting a kidney from a deceased or living donor took part. The …

This study tested a drug called patiromer in 262 Chinese adults with chronic kidney disease and high potassium levels. Participants took patiromer for 4 weeks, then some switched to placebo for 8 weeks to see if potassium stayed controlled. The goal was to manage potassium safely…

This study tested a new drug called BAY 3283142 in 1222 adults with chronic kidney disease and high protein in their urine. Participants took either the drug or a placebo on top of their usual treatments for 16 weeks. The goal was to see if the drug could lower urine albumin leve…

This study followed 27 HIV-positive people with kidney failure who received a kidney transplant. All were on a three-drug HIV treatment including Raltegravir. The goal was to see how many had graft rejection within 6 months, using blood tests and kidney biopsies.

This study looked at whether dapagliflozin, a diabetes drug, can reduce protein in the urine (proteinuria) in people who have had a kidney transplant and have chronic kidney disease. Researchers followed 55 patients for 6 months to see if the drug lowered protein levels and prote…

This study tested two different drug combinations (Simulect or ATG, plus standard medications) in 60 kidney transplant patients at high risk of rejection. The goal was to see which approach better prevents treatment failure, including rejection, graft loss, or death, within 6 mon…

This study tested a new drug called MT-6548 against a standard treatment (darbepoetin alfa) for anemia in people on dialysis for chronic kidney disease. About 323 participants in Japan received either the new drug or the standard one to see if it worked as well at keeping hemoglo…

This phase 3 trial tested an oral drug called vadadustat (MT-6548) in 24 Japanese adults on hemodialysis who had anemia due to chronic kidney disease. The goal was to see if the drug could raise and maintain healthy hemoglobin levels safely. Participants took the tablet daily, an…

This study tested a new dialysis filter (Clearum HS) in 20 adults with end-stage kidney disease who were already on dialysis. The goal was to see if the new filter safely removes waste products like urea as well as or better than standard filters. Participants used their usual fi…

This study tested whether a new training package called TEACH-PD could lower infection rates in patients starting peritoneal dialysis (PD). Over 1,400 adults from multiple countries were randomly assigned to receive either the TEACH-PD training or standard PD training. The resear…

This study tested whether levocetirizine, an allergy medication, can reduce protein leakage in the urine of people with diabetic kidney disease. The trial enrolled 60 adults aged 40-65 with type 2 diabetes and early kidney damage. Researchers measured changes in albuminuria to se…

This study tested whether a new medicine called CagriSema (a combination of two drugs) can reduce kidney damage in people with chronic kidney disease, type 2 diabetes, and overweight or obesity. About 626 participants received either CagriSema, one of the two drugs alone, or a pl…

This study tested a new drug called CU01-1001 in 240 adults with type 2 diabetes and early kidney damage (albuminuria). Participants took the drug or a placebo for 24 weeks to see if it could reduce protein leakage in urine, a sign of kidney health. The goal is to find a treatmen…

This study tested whether an educational worksheet plus health coaching could help people with chronic kidney disease improve their blood pressure. 320 adults with moderate to severe kidney disease and uncontrolled high blood pressure took part. The goal was to see if the coachin…

This study tested a personalized way to dose the blood thinner enoxaparin in 50 children after kidney transplant. The goal was to prevent dangerous blood clots in the new kidney while avoiding excessive bleeding. Doctors used a computer model (Bayesian approach) to adjust doses b…

This study looked at 45 adults on hemodialysis who had a blocked superior vena cava (SVC), a large vein in the chest. Doctors used surgery or a tube-like device to reopen the vein and relieve symptoms. The goal was to improve blood flow and quality of life for these patients.

This study tested whether a low dose of the blood thinner rivaroxaban (Xarelto) could reduce major heart problems like heart attacks and strokes in people with advanced chronic kidney disease or kidney failure on dialysis. About 1,753 participants were randomly assigned to receiv…

This study tested a new dialysis needle called the Argyle Safety Fistula Cannula with an anti-reflux valve. It was used in 40 adults with end-stage kidney failure who get dialysis three times a week for 12 weeks. The goal was to see if the needle is safe and works well for hemodi…

This pilot study tested whether using central blood pressure (measured near the heart) instead of the usual arm cuff leads to better outcomes in 116 people with advanced chronic kidney disease. Participants were randomly assigned to either a central BP target or a standard arm BP…

This study tested an experimental cell therapy called REACT (rilparencel) in 53 adults with type 1 or 2 diabetes and chronic kidney disease. The therapy involves injecting a person's own kidney cells into their kidneys to see if it can slow the loss of kidney function. The goal i…

This study tested whether kidneys from deceased donors with hepatitis C can be safely transplanted into people without hepatitis C. All 201 participants received antiviral medication after transplant to clear any infection. The goal was to see if this approach could safely increa…

This study looked at whether garlic supplements can improve blood vessel function and reduce inflammation in adults with kidney failure who are on hemodialysis. Fifty-eight patients took garlic extract or a placebo for a period of time. Researchers measured markers of inflammatio…

This study tested whether an extended-release version of the diuretic torsemide helps heart failure patients get rid of more salt after lunch compared to the standard immediate-release version. Twenty adults with stable heart failure took both forms in a random order, and researc…

This study tested a new dialysis filter called ELISIO-HX in 22 adults with kidney failure. Participants used the new filter three times a week for 12 weeks. The goal was to see if it safely maintained albumin levels while improving removal of certain waste products. The trial is …

This pilot study tested a combined bone marrow and kidney transplant from a partially matched family donor in 10 people with both a blood disorder and chronic kidney disease. The goal was to treat both conditions at once and possibly reduce the need for lifelong anti-rejection dr…

This study tested the drug dapagliflozin (a diabetes medicine) against a placebo in 220 people on dialysis for kidney failure, with or without diabetes. The goal was to see if the drug could improve heart structure and be safe. Participants took the drug or placebo for a period, …

This study tested a new drug called zilebesiran in 375 adults with high blood pressure that wasn't controlled by their current medications. Participants received either zilebesiran or a placebo as an add-on to their usual pills. The goal was to see if zilebesiran could lower bloo…

This study looked at 1,819 elderly patients (aged 60+) with end-stage kidney disease to see if getting a living donor kidney transplant that is not a perfect match (ABO- or HLA-incompatible) helps them live longer compared to waiting for a compatible deceased donor. The approach …

This study tests whether giving donor stem cells and a drug called Campath-1H can help kidney transplant recipients stop taking anti-rejection medications permanently. Eighty-eight patients receiving a kidney from an identical sibling will get the stem cell infusions and temporar…

This study tested a drug called TOUR006 in 143 adults with chronic kidney disease and high levels of a protein linked to inflammation (hs-CRP). The goal was to see if monthly or quarterly shots could safely lower inflammation. The study is complete, and results will show if the d…

This study tested whether a once-weekly injection of exenatide (a diabetes drug) can protect the heart and kidneys in 57 adults with type 2 diabetes and mild kidney problems. Participants received either exenatide or a placebo for 38 weeks. Researchers measured blood and urine ma…

This study tested whether people with type 2 diabetes and kidney damage can safely participate in a clinical trial from home. Twelve participants took the drug empagliflozin, and depending on their response, some added or switched to finerenone. The goal was to see if remote data…

This early-stage study tested a new approach to help kidney transplant recipients stop taking anti-rejection drugs. Eight adults received donor stem cells along with a special mix of medications to see if their bodies would accept the new kidney without needing lifelong drugs. Th…

This study looked at whether community health workers (CHWs) can help low-income, mostly minority adults better manage chronic diseases like diabetes, high blood pressure, and obesity. Over 10 months, 202 participants either received CHW support plus standard care or just standar…

This study tested an experimental drug called MK-2060 in 506 adults with end-stage kidney disease who need regular dialysis through a special tube (graft) in their arm. The goal was to see if the drug could prevent dangerous blood clots from blocking the graft, which would requir…

This study tested an automated insulin delivery system (a smart pump) in 15 adults with type 1 or type 2 diabetes who also had advanced kidney disease or were on dialysis. Participants used the system for 8 weeks, then switched to their usual care for another 8 weeks. The goal wa…

This study tested whether using a special scale (bioimpedance) to measure body fluid levels each month could help doctors set the right dry weight for hemodialysis patients. The goal was to reduce serious complications like heart attacks, strokes, and low blood pressure during di…

This study tested a drug called finerenone in about 1,580 adults with chronic kidney disease not caused by diabetes. The goal was to see if adding finerenone to standard care could slow kidney function decline better than a placebo. Participants took the drug or placebo daily for…

This study tested a digital program called DDEP, delivered through the LINE messaging app, to help people with chronic kidney disease (CKD) and their care partners make healthy lifestyle changes. Over six months, 208 participants either received the DDEP plus usual care or usual …

This small completed study looked at a blood filtering procedure called double-filtration plasmapheresis (DFPP) in 5 kidney dialysis patients with very high levels of lipoprotein(a), a fatty substance linked to heart disease and blood clots. The goal was to see if DFPP could lowe…

This study tested a new drug called MT1013 in 115 adults with chronic kidney disease who are on dialysis and have a condition called secondary hyperparathyroidism (high parathyroid hormone). The goal was to see if the drug could safely lower hormone levels by at least 30%. Partic…

This study looked at whether a 12-week course of dapagliflozin can improve blood vessel function in people with chronic kidney disease. 32 participants took the drug, and researchers measured changes in artery health using ultrasound. The goal was to see if the drug could help co…

This study tested whether adding the drug atrasentan to standard care (including SGLT2 inhibitors) can reduce protein in the urine of people with IgA nephropathy, a kidney disease. 54 adults with biopsy-confirmed IgA nephropathy participated. The main goal was to see if atrasenta…

This study tested whether a thorough medication review at hospital admission and discharge could reduce mistakes and prevent patients with chronic kidney disease from being readmitted within 90 days. Researchers compared 323 patients who received this extra service to a similar g…

This study looked at how well the drug Roxadustat works for anemia in people with diabetic kidney disease stages 3-4. 124 participants took the drug for 24 weeks, and researchers measured changes in hemoglobin and iron levels. The goal was to see if the drug can safely raise red …

This study examined whether adding a monthly blood-cleaning procedure (hemoperfusion) to regular dialysis can reduce the risk of death, especially from heart or brain problems. Researchers reviewed records of 879 adult dialysis patients over 10 years, comparing those who received…

This study tested a new drug called FR104 in 10 people who received a kidney transplant. The goal was to see if the drug is safe and helps prevent the body from rejecting the new kidney. Researchers monitored side effects and kidney function over time.

This study tested whether dapagliflozin, a drug typically used for diabetes, can slow kidney decline, improve anemia, and support heart health in 100 adults with chronic kidney disease who do not have diabetes. Participants took either the drug or a placebo daily for 12 months al…

This pilot study tested whether a multicultural anti-inflammatory diet is practical and acceptable for racial/ethnic minorities with chronic kidney disease (CKD). Researchers enrolled 18 adults with stage 3 CKD in the Bronx, providing dietary counseling tailored to each person's …

This study tested a new medicine, BI 764198, in 67 adults with a kidney disease called FSGS. Participants took different doses of the medicine or a placebo daily for 12 weeks. The goal was to see if the medicine could reduce protein in the urine, a sign of better kidney health. T…

This study looked at whether weight-loss surgery (vertical sleeve gastrectomy) can improve kidney, heart, and pancreas function in teens aged 12-21 with type 2 diabetes and obesity. Researchers measured blood flow to the kidneys, kidney filtering ability, and insulin production b…

This study tested a drug called MCI-196 in 245 adults on dialysis who have high phosphate levels, a common problem in advanced kidney disease. After a 4-week washout and 12-week dose adjustment, patients were randomly assigned to continue MCI-196 or switch to a placebo for 4 week…

This study tested the long-term safety of a drug called MCI-196 (Colestilan) in 116 adults with stage 5 chronic kidney disease who are on dialysis and have high phosphorus levels. Participants took flexible doses of the drug for 52 weeks. The main goal was to see how many side ef…

This study tested a drug called MCI-196 in 336 adults on dialysis with chronic kidney disease and high phosphorus levels. After a washout period, some patients received MCI-196 and others a placebo to see if the drug could safely lower phosphorus. The goal was to manage a common …

This Phase 3 trial tested MCI-196, a drug that binds phosphorus and lowers cholesterol, in 642 adults on dialysis with chronic kidney disease. Participants received either MCI-196 or a placebo for 12 weeks. The goal was to see if the drug could safely reduce both serum phosphorus…

This large Phase 3 trial tested whether AST-120, a spherical carbon adsorbent taken as a pill, can slow the progression of chronic kidney disease. Over 1,000 adults with moderate to severe kidney disease were randomly assigned to receive AST-120 or a placebo, in addition to their…

This Phase 3 trial tested whether AST-120, a spherical carbon adsorbent taken as a powder, can slow the progression of chronic kidney disease. Over 1,000 adults with moderate to severe kidney disease received either AST-120 or a placebo alongside their usual care. The main goal w…

This study tested the long-term safety of a drug called MCI-196 in 632 adults with chronic kidney disease on dialysis who have high phosphorus levels. Participants took the drug for up to 52 weeks to see how it affected their phosphorus and cholesterol. The goal was to help contr…

This study tested a new drug called MCI-196 to lower bad cholesterol in people with advanced chronic kidney disease who are on dialysis. About 260 adults took part, comparing MCI-196 to a standard statin (simvastatin) and a placebo. The goal was to see if MCI-196 works better tha…

This study tested whether canagliflozin, a diabetes drug, can slow kidney decline in 308 Japanese patients with diabetic nephropathy. Participants took either the drug or a placebo daily for about two years. The main goal was to see if fewer people on the drug had a 30% drop in k…

This phase 2 trial tested HRS-7535, a new drug, in 281 adults with type 2 diabetes and diabetic kidney disease. Participants received either the drug or a placebo for 16 weeks. The main goal was to see if HRS-7535 could reduce protein in the urine, a sign of kidney damage, and he…

This study tested whether pentoxifylline, a drug used for blood flow issues, can reduce inflammation and slow kidney disease in non-diabetic patients. 42 adults with moderate chronic kidney disease took either standard therapy alone or standard therapy plus pentoxifylline for 6 m…

This study tested a special device called the Amplifi Vein Dilation System in 19 adults with end-stage kidney disease who needed a vein connection (fistula) for dialysis. The goal was to see if the device could safely widen the vein and help the fistula mature faster. The study m…

This early-stage trial studied how ziltivekimab works in the body of 24 Chinese adults with chronic kidney disease and signs of inflammation. Participants received either the drug or a placebo as three injections over several weeks. The study measured drug levels and safety, with…

This study looked at whether taking L-carnitine or Coenzyme Q10 supplements could lower oxidative stress (a type of cell damage) in adults with end-stage kidney disease who are on regular hemodialysis. Fifty-two participants took one of the supplements or a placebo for 12 weeks, …

This study tested a new drug called KBP-5074 in 162 people with moderate-to-severe chronic kidney disease whose blood pressure was still high despite treatment. Participants took either a low or high dose of the drug or a placebo daily for 84 days. The main goal was to see if the…

This study tested a drug called ziltivekimab in 264 people with advanced chronic kidney disease and high inflammation. Participants received monthly injections of either a placebo or one of three doses of ziltivekimab for six months. The goal was to see if the drug could safely l…

This study tested a program that helps low-income African Americans with diabetic kidney disease get their basic needs, like food and housing, while also providing lifestyle coaching. Fifty participants received one-on-one sessions and a device to track blood sugar and blood pres…

This study tested a device called Carry Life UF in 28 adults with end-stage kidney disease who use continuous ambulatory peritoneal dialysis (CAPD) at home. The device adds glucose to the dialysis fluid already in the belly to help remove more fluid over a 5-hour session. Researc…

This study looked at 78 people with advanced kidney failure who needed a surgery to create an arteriovenous fistula (a connection between an artery and vein) for dialysis. The goal was to see if using a nerve block (axillary block) instead of local anesthesia could reduce early p…

This study tested whether taking oral L-carnitine (a natural supplement) three times a week for three months could reduce inflammation and improve nutrition in 50 adults with advanced kidney failure on chronic hemodialysis. Participants were randomly assigned to receive either L-…

This study looked at whether taking vitamin C by mouth can safely lower the amount of erythropoietin (a drug for anemia) needed by people with end-stage kidney disease on regular dialysis. Sixty adults on stable dialysis with low iron levels and moderate anemia took part. Researc…

This study looked at whether taking kefir peptides for three months could help people with stage 3 or 4 chronic kidney disease. Researchers measured kidney function, protein in urine, and signs of inflammation. The goal was to see if this supplement could support disease control,…

This pilot study tested a combination of two drugs—belatacept and a proteasome inhibitor—to lower strong immune antibodies in 5 highly sensitized kidney transplant candidates. The goal was to increase their chances of finding a compatible donor. The study has completed, but resul…

This study tested a new device called the everlinQ endoAVF System in 24 adults with kidney failure who need dialysis. The device uses magnets and radiofrequency energy to create a connection between an artery and a vein, providing a way to access the blood for dialysis. The goal …

This study tested a device that creates a connection between an artery and a vein in the arm to make dialysis easier for people with kidney failure. Thirty-two adults with chronic kidney disease who needed dialysis took part. The main goals were to see if the connection worked we…

This completed study looked at whether remote virtual reality rehabilitation and a ketoacid supplement (Ketosteril) could help people with chronic kidney disease (stages 3b-5) who also have mild cognitive issues. The 15 participants were split into groups: one got the supplement,…

This study tested whether a nurse-led nutritional education program could help hemodialysis patients in Morocco lower dangerously high potassium levels. Thirty adults with end-stage kidney disease received 12 weeks of dietary guidance on potassium, fluids, and salt. After the pro…

This study tested whether using a smart grip device with a game-like app could improve blood vessel function and hand strength in 52 kidney patients who had just had a first arteriovenous fistula surgery. Participants used the device daily for eight weeks, and researchers tracked…

This study tested whether a probiotic supplement containing two live bacteria strains could help people with diabetic kidney disease. Fifty adults with type 2 diabetes and early-stage kidney problems took either the probiotic or a placebo daily for 6 months. Researchers measured …

This study tested whether a daily probiotic drink could slow the buildup of calcium in blood vessels (vascular calcification) in 84 adults with advanced chronic kidney disease. Participants took either the probiotic or a placebo for 6 months, and researchers tracked changes in ki…

This completed Phase 2 trial tested two drugs, HRS-1780 and henagliflozin, in 181 adults with chronic kidney disease. Participants took the drugs or placebos for 13 weeks to see if the drugs could reduce protein in the urine, a sign of kidney damage. The study aimed to find a new…

This study tested a new device called the FLEX System that creates a connection between an artery and a vein (AV fistula) using a tube inserted through the skin, instead of surgery. The goal was to see if this method is safe and works well for people with chronic kidney disease w…

This study tested a new device called FLEX-1 that creates a special blood vessel connection (called an arteriovenous fistula) for people with advanced kidney disease who need dialysis. Sixteen adults with stage 4 or 5 chronic kidney disease took part. The goal was to see if the d…

This study looked at whether continuing a drug called sodium zirconium cyclosilicate (Lokelma) after hospital discharge helps people with chronic kidney disease maintain normal potassium levels. 186 hospitalized patients were randomly assigned to either continue the drug or recei…

This study tested a new device called FLEX-1 to create a special blood vessel connection (arteriovenous fistula) for dialysis in 17 adults with advanced chronic kidney disease. The goal was to see if the device is safe and works well for hemodialysis. The study focused on complic…

This study tested whether retatrutide, a medication being studied for weight loss, can help preserve kidney function in 146 adults who are overweight or obese and have chronic kidney disease (with or without type 2 diabetes). Participants received the drug or a placebo for about …

This early-stage trial tested a new drug called AZD4144 in 29 people who have both heart disease and chronic kidney disease. The main goal was to see if the drug is safe and if it lowers certain markers of inflammation in the blood. The study compared the drug against a placebo o…

This study tested whether sodium phenylbutyrate, a drug already used for other conditions, can reduce a marker of kidney injury in people with proteinuric kidney disease. 26 participants took the drug for 14 days. The goal was to see a 50% drop in a urine marker called Lcn2, whic…

This study tested a new medicine called ASKP1240 in 149 people who received a new kidney. The goal was to see if it could prevent the body from rejecting the kidney as well as or better than current standard treatments. Participants received different combinations of drugs, and r…

This phase 3 trial tested a lab-grown blood vessel (Human Acellular Vessel, or HAV) against the standard surgically created fistula in 242 people with end-stage kidney disease on hemodialysis. The goal was to see which option works better for providing reliable access to filter b…

This study tested a single dose of a new drug called ASKP1240 in 50 people who just received a kidney transplant. The goal was to see how the drug moves through the body, how safe it is, and how well it works. Participants were randomly assigned to get the drug or a placebo, and …

This Phase 3 trial tested a new drug called AP301 in 474 Chinese adults on dialysis who had high phosphorus levels. Participants took AP301, a low dose of AP301, or the standard drug sevelamer carbonate with meals. The main goal was to see how well AP301 lowers phosphorus compare…

This study tested a new medicine called TS-172 in 101 adults on hemodialysis who had high phosphorus levels. The goal was to see if the drug could help more patients reach a safe phosphorus level in their blood. Results showed that TS-172 was better than a placebo at controlling …

This study looked at whether giving hospital-level care to acutely ill adults in their own homes in rural areas works well. 160 people with various conditions like infections, heart failure, or COPD took part. The goal was to see if this approach could lower costs and help patien…

This study tested a drug called daprodustat in children aged 3 months to under 18 years who have anemia due to chronic kidney disease. The goal was to see how the drug moves through the body and if it is safe. Only 4 children took part, and they received the drug for up to 52 wee…

This completed study tested a single dose of the experimental drug Gemini in 40 adults with stage 3 or 4 chronic kidney disease. The main goal was to check safety and side effects compared to a placebo. Researchers also measured how the drug moves through the body and its effect …

This study tested a new medicine called tegoprubart in 127 people who received a kidney transplant. The goal was to see if it works better than the standard drug tacrolimus at preventing the body from rejecting the new kidney. Participants took the study drug and were monitored f…

This Phase 3 trial tested whether finerenone, a drug already approved for kidney disease in type 2 diabetes, can also slow kidney damage in people with type 1 diabetes. 241 adults with both conditions took either finerenone or a placebo for 6 months, alongside their usual care. R…

This study tested a special collagen implant coated with sirolimus (rapamycin) placed around a new dialysis fistula during surgery. The goal was to see if it helps the fistula become usable for dialysis sooner and stay working longer. About 269 people with advanced kidney disease…

This early-stage study tested a new drug called AZD4144 in 28 adults with obesity to see if it is safe and how it affects inflammation markers in the blood. Participants took either the drug or a placebo daily for a short time. The goal was to check for side effects and measure c…

This study tested whether a routine biopsy three months after kidney transplantation can help doctors adjust immunosuppressive drugs to prevent graft loss and reduce side effects. 346 patients were split into two groups: those with mild inflammation received extra steroids, while…

This phase 3 trial tests a sirolimus-releasing collagen implant placed around a new dialysis fistula during surgery. The goal is to help the fistula mature faster so it can be used for dialysis. The study involves 136 people aged 65+ with kidney failure who are new to hemodialysi…

This study tested whether adjusting the first dose of the immunosuppressant drug tacrolimus based on a patient's CYP3A5 gene helps reach the right blood levels faster after kidney transplant. 280 kidney transplant recipients were randomly assigned to receive either a standard dos…

This phase 2 trial tested the safety and effectiveness of metformin extended release (XR) in 12 adults with type 2 diabetes and mild to moderate chronic kidney disease (stages 1 to 3). Participants took metformin XR tablets for 6 to 12 weeks, and researchers monitored their blood…

This study tested whether sevelamer carbonate, a drug that binds phosphate in the gut, can lower levels of a hormone called FGF-23 in people with chronic kidney disease (CKD) who are not yet on dialysis. The trial included 98 adults with moderate to severe CKD and high FGF-23 lev…

This study tested whether clopidogrel, a blood thinner, could prevent early failure of arteriovenous fistulas in 877 people with kidney failure starting hemodialysis. While clopidogrel reduced the risk of fistula clotting, it did not improve the chance that the fistula would be u…

This study uses machine learning to tell apart diabetic kidney disease from other kidney diseases in people with type 2 diabetes. Researchers analyzed data from over 2,200 patients across 14 medical centers to build a model that uses routine clinical and lab information. The goal…

This study tested a short questionnaire called SCORED to see if it can accurately identify adults in Asia who are at risk for chronic kidney disease (CKD). Over 1,400 people took part across multiple hospitals. Researchers measured how well the questionnaire predicted kidney prob…

This early-phase trial tested a radioactive tracer called Tc-99m-Tilmanocept to see if it can help doctors detect diabetic kidney disease using SPECT/CT scans. The study involved 57 adults with suspected diabetic kidney disease. The goal was to measure how the tracer behaves in t…

This study tested whether a small, chest-worn ECG device can detect high potassium levels (hyperkalemia) in people with chronic kidney disease undergoing dialysis. Thirty-two patients wore the device during dialysis sessions, and the ECG readings were compared with blood test res…

This study tested whether advanced ultrasound techniques can predict if an arteriovenous fistula (AVF) will work for dialysis in people with end-stage kidney disease. Researchers measured artery stiffness and blood flow in 76 patients before and after AVF surgery. The goal was to…

This study tested whether an electronic stethoscope can help doctors detect narrowing (stenosis) of the arteriovenous fistula in hemodialysis patients. Researchers collected sound recordings from 30 adults on long-term dialysis over 3 months. The goal was to see if the device cou…

This study tested a new wearable patch that collects sweat to measure sodium and creatinine levels, which are important for monitoring kidney health and dehydration. Five adults with kidney disease wore the patch while their sweat was analyzed using a special light-based techniqu…

This study tested whether special ultrasound scans can detect kidney damage in people who have received a kidney transplant. 141 transplant recipients had ultrasound imaging at 15 days, 3 months, and 12 months after surgery. The goal was to see if these scans could measure kidney…

This study looked at tiny particles called extracellular vesicles found in urine to see if they can help tell the difference between healthy kidneys and chronic kidney disease. Researchers measured these particles in 143 people, including healthy volunteers and patients with kidn…

This study tested a six-month home-based exercise program using elastic bands to prevent frailty in 120 adults aged 50-85 with type 2 diabetes and chronic kidney disease. The program aimed to improve muscle strength and daily functioning. Researchers measured changes in frailty s…

This study tested whether pentoxifylline, a drug that improves blood flow, can prevent kidney damage caused by contrast dye used in medical imaging. The trial included 70 adults with chronic kidney disease who were in the intensive care unit and needed contrast dye. Researchers m…

This Phase 2 trial tested whether thymalfasin, a synthetic version of a natural immune-boosting protein, could prevent COVID-19 infection in 189 kidney dialysis patients. These patients are at high risk due to weakened immune systems and frequent clinic visits. The study measured…

This study tested whether regular retraining on infection prevention can lower peritonitis rates in new peritoneal dialysis patients. Over 700 adults from eight European countries were randomly assigned to either standard care or extra testing and retraining on dialysis technique…

This large study tested whether giving sodium bicarbonate (a type of fluid) or N-acetylcysteine (a supplement) before and after angiography could prevent serious kidney problems, including death or need for dialysis. Over 5,000 high-risk patients with kidney disease took part. Th…

This study tested whether listening to music and applying acupressure before needle insertion can reduce pain in dialysis patients. 72 participants were split into four groups: music plus acupressure, acupressure alone, music alone, or standard care. Pain was measured during thre…

This study tests whether a non-invasive device that sends mild electrical pulses to nerves in the neck can reduce restless legs syndrome in people undergoing dialysis. Thirty-six adults aged 40-50 will receive either real or sham stimulation three times a week for four weeks. Res…

This study looked at whether art therapy can reduce anxiety and improve mental strength in people with chronic kidney disease who are on hemodialysis. Eighty adults who had been on dialysis for at least six months took part. The results measured changes in anxiety and psychologic…

This study tested whether a structured education program could help people on dialysis manage chronic itch and improve their quality of life. 104 adults with kidney failure and itch took part, receiving either two educational sessions or standard care. The program focused on unde…

This study tested whether a combined aerobic and resistance exercise program could improve physical function and muscle health in people receiving peritoneal dialysis. Thirty-six adults on dialysis for at least six months were split into an exercise group and a usual-care group. …

This pilot study tested an optimized dialysis technique using a special membrane and biofeedback software to see if it helps kidney failure patients recover faster after treatment. 18 patients on standard dialysis who took at least 4 hours to recover were observed. The study meas…

This study tested whether wearing virtual reality goggles during the needle stick for dialysis can lower pain and anxiety. Fifty adults on hemodialysis were randomly assigned to either watch VR content during the procedure or receive usual care. The results will show if a simple,…

This study tested a device that uses ultrasound to help guide needles into the blood vessels of people with end-stage kidney disease who need dialysis. Ten adults with an arteriovenous fistula or graft took part. The main goal was to see if the device could help place needles suc…

This study looked at whether online laughter therapy could help people on hemodialysis feel less depressed, anxious, and stressed, and improve their quality of life. Sixty-nine adults who were on dialysis took part. They did laughter therapy sessions online. The results showed th…

This study tested whether teaching children aged 9-12 how to manage their time during haemodialysis can reduce their anxiety and fear. Twenty children were split into two groups: one received the training, the other got usual care. Researchers measured anxiety and fear levels bef…

This study tested if hand reflexology massage could reduce fatigue and anxiety in adults with end-stage kidney disease who are on maintenance hemodialysis. 70 patients were split into two groups: one received eight 21-minute hand massage sessions during dialysis over four weeks, …

This study tested whether massage and progressive muscle relaxation exercises can reduce the frequency and severity of muscle cramps in people undergoing hemodialysis. 79 patients participated, and the goal was to see if these non-drug approaches offer relief. The findings could …

This study tested a 12-week online mind-body program for adults with chronic conditions like heart failure, cancer, and liver disease. The program included mindful movement, meditation, breathwork, and coping skills. Researchers measured changes in anxiety, depression, fatigue, a…

This study tested whether a 16-week program of cycling during dialysis sessions could improve heart function in 30 adults with kidney failure and early signs of heart stiffness. Participants first received standard care for 16 weeks, then added supervised cycling during dialysis …

This study tested a drug called nemolizumab to see if it can reduce severe itching in adults with chronic kidney disease who are on dialysis. 258 participants received either nemolizumab or a placebo as injections every 4 weeks for 12 weeks. The main goal was to see how many peop…

This study tested whether doing handgrip exercises before and after surgery can improve the size and function of dialysis fistulas in people with advanced kidney disease. 40 patients participated, and the main goal was to see if the fistula diameter increased. The approach is sim…

This study tested whether light exercise or a technique called remote ischaemic preconditioning (rIPC) — using a blood pressure cuff to briefly restrict blood flow to the arm — could protect the heart during dialysis. 33 adults on hemodialysis took part in three sessions: one wit…

This study tested whether a 10-minute vibration massage or static stretching exercise could reduce the severity and duration of muscle cramps that often occur during hemodialysis. Thirty adults with chronic kidney disease on dialysis were randomly assigned to receive vibration ma…

This study tested a program led by nurses that combined personalized nutrition advice and supervised exercise for people on hemodialysis. The goal was to see if it could improve their overall quality of life. 120 adults on long-term dialysis took part, with half receiving the pro…

This study tested whether lowering the temperature of the dialysis fluid from 36.5°C to 36°C could reduce the tiredness patients often feel after dialysis. Fifty-seven adults on maintenance hemodialysis received three sessions of 'cold dialysis' over one week. Researchers measure…

This study tested two non-drug methods—reflexology (foot massage) and sleep hygiene education—to improve sleep and comfort in 60 adults on hemodialysis. Both approaches helped, but reflexology was more effective. The results suggest a simple, drug-free option for better rest in d…

This study tested whether guided breathing exercises (4-7-8 breathing and diaphragmatic breathing) can help reduce pain, anxiety, and improve comfort during the needle insertion for dialysis. 90 adults on hemodialysis were split into three groups: two doing different breathing ex…

This study tested whether a six-month aerobic exercise program done during dialysis sessions could improve heart function in people with end-stage kidney disease. Eighteen adults on hemodialysis pedaled a stationary bike for 30 minutes, three times a week, while receiving treatme…

This study tested whether adding empagliflozin (a diabetes drug) to standard diuretics helps hospitalized heart failure patients with moderate to advanced kidney disease urinate more fluid. 25 participants were given the combination, and researchers measured urine output. The goa…

This study tested whether nurse-led mindfulness sessions could help people on hemodialysis feel better and follow their treatment more closely. Eighty patients were split into two groups: one received six weekly mindfulness sessions, the other got usual care. After the program, t…

This study tested whether giving oral care education and reminder cards to adults on hemodialysis could improve their oral health and help them adjust to their chronic disease. 82 patients received one-on-one training, a reminder card, and a checklist to track daily oral care. Re…

This study looked at whether adding exercise during dialysis sessions can help older adults (over 60) with chronic kidney disease improve their muscle strength and daily function. Ninety participants were split into three groups: one did cycling plus breathing exercises, another …

This study looked at whether a 26-week exercise program, including home-based resistance training and cycling during dialysis, could reduce symptom burden and improve quality of life in 133 adults with end-stage kidney disease on chronic hemodialysis. Participants were assessed a…

This study tested whether a 12-week nurse-led program could help people on hemodialysis feel better and function better. 220 patients were split into two groups: one got the extra program during dialysis sessions, and the other got standard care. The program included light exerci…

This study looked at whether doing specific exercises during dialysis sessions can improve how well people with chronic kidney disease function in daily life. Fifty-six adults on maintenance hemodialysis were split into groups doing lumbar stabilization exercises, breathing muscl…

This study looked at whether a training booklet based on Roy's Adaptation Model could help kidney patients who are starting immunosuppressive therapy. The booklet covers topics like what the drugs do, side effects, and how to adapt to the disease. Researchers measured patients' m…

This study tested whether watching calming VR videos (nature, forest, seaside) during needle insertion could reduce pain, distress, and improve comfort in 52 hemodialysis patients. Patients used VR headsets starting three minutes before the procedure. The goal was to see if this …

This study tested whether abdominal massage can relieve constipation in people receiving hemodialysis. 49 adults took part. Researchers measured changes in constipation severity, quality of life, and stool consistency. The goal was to see if this simple, noninvasive technique cou…

This study tested whether doing art therapy during hemodialysis sessions can reduce common symptoms like fatigue and discomfort, and improve patients' sense of spiritual well-being. Sixty adults on dialysis took part; half received at least 30 minutes of art therapy per session w…

This study looked at whether remote Reiki (a hands-off energy therapy) could help 30 adults on dialysis who were waiting for an organ transplant. Participants received distant Reiki sessions, and researchers measured changes in hopelessness, fatigue, and pain using standard quest…

This study looked at whether doing resistance or flexibility exercises while receiving hemodialysis can improve health and quality of life. 49 adults on regular dialysis were split into three groups: resistance exercise, flexibility exercise, or usual care. Researchers measured c…

This study tested a traditional Chinese medicine patch made from herbs like ginger and Artemisia on 21 dialysis patients who had pain from their fistula. The patch was placed on specific acupoints during dialysis sessions for 4 weeks. Researchers measured pain, depression, and qu…

This study tested whether a guided mindfulness meditation program, practiced during dialysis sessions, could reduce anxiety and improve spiritual well-being in people with chronic kidney disease. Fifty-eight adults on hemodialysis were randomly assigned to either the meditation g…

This study tested a nerve block called a supraclavicular brachial plexus block in 50 children aged 6 to 18 who were having surgery to create an arteriovenous fistula for dialysis. The goal was to see if the block could reduce the amount of opioid pain medicine needed during and a…

This study looked at whether a 12-week home exercise program could help people aged 45 and older with advanced chronic kidney disease (stages 4-5) who are not on dialysis. The program included strength and aerobic exercises done 3-4 times a week. Researchers measured changes in m…

This study looked at whether resistance exercises or relaxation therapy better improve physical function and quality of life in people with mild-to-moderate chronic kidney disease. Fifty adults aged 30 to 65 took part, with one group doing both relaxation and resistance exercises…

This study tested whether a nerve block called an erector spinae plane (ESP) block can reduce pain and the need for strong painkillers after a kidney transplant. Forty adults having a kidney transplant were randomly assigned to receive either the ESP block or no block. All patien…

This study tested whether virtual museum visits using VR glasses during hemodialysis can reduce symptoms and anxiety. Sixty patients were randomly assigned to either a virtual museum tour or standard care. The goal was to see if this simple, non-drug approach improves well-being …

This study compared two types of nerve blocks — erector spinae plane block and transmuscular quadratus lumborum block — for pain after kidney transplant. Forty adults received one of the two blocks with bupivacaine. Researchers measured pain scores and painkiller use over 24 hour…

This study tested two simple, drug-free ways to reduce pain when inserting needles for dialysis. 75 patients were split into three groups: one listened to calming music, one looked at their healthy arm in a mirror, and one received standard care. Pain scores were compared right a…

This study tested whether inhaling lavender oil can reduce headache severity and anxiety in people undergoing hemodialysis. 62 patients were split into two groups: one inhaled lavender oil during dialysis sessions for 4 weeks, while the other received standard care. Researchers m…

This study tested whether cycling for 30 minutes during each dialysis session, three times a week for three months, could improve blood flow in the legs of people on chronic hemodialysis. The goal was to see if this simple exercise could help prevent serious complications like wo…

This small pilot study tested a cognitive behavioral program to help reduce fatigue in people with chronic kidney disease. Five adults with moderate-to-severe kidney disease took part in remote sessions. The goal was to see if the program was acceptable and to gather data for a l…

This study tested a program that sends text reminders and uses social support and game-like features to encourage people with chronic kidney disease, diabetes, and high blood pressure to check their blood pressure regularly. 70 adults from a University of Pennsylvania clinic part…

This study tested whether press needle acupuncture can reduce severe itching in people with chronic kidney disease who are on dialysis. 38 patients received either a real press needle or a sham (fake) needle on specific acupoints for 4 weeks. The goal was to see if the real needl…

This study looked at whether smelling geranium essential oil can help reduce tiredness and improve sleep in people receiving dialysis for kidney failure. 90 adults on dialysis took part in a crossover trial where they received both the aromatherapy and a placebo at different time…

This study looked at whether a simple home-based exercise program could help reduce anxiety and depression in people receiving hemodialysis. 54 adults on dialysis were split into two groups: one did home exercises for 6 months, the other did not. Researchers measured changes in d…

This study tested whether sleep hygiene education plus motivational interviewing can improve sleep and quality of life in people on hemodialysis. Forty patients were split into two groups: one received face-to-face sleep training plus four online motivational sessions over six we…

This study tested whether nurse-led stretching exercises during dialysis sessions can reduce the burden of muscle cramps. Sixty adults on maintenance hemodialysis who had leg cramps were split into two groups: one did supervised lower-leg stretches during dialysis twice a week fo…

This small pilot study looked at whether treating constipation with a common laxative (lactulose) is practical for people with chronic kidney disease. Fourteen participants took lactulose daily for up to 6 weeks. The main goal was to see if people would stick with the treatment a…

This study tested whether lidocaine or benzocaine sprays could reduce pain and improve satisfaction during needle insertion for hemodialysis. 60 patients were randomly assigned to receive one of the two numbing sprays or a placebo. The goal was to see if these sprays make the pro…

This study tested whether listening to live music, hearing a ney flute, or interacting with a robotic parrot could help people on dialysis feel less anxious and less tired. 64 adults on regular hemodialysis took part. Researchers measured their anxiety and fatigue levels before, …

This study tested if doing hand grip exercises for six weeks helps the arm blood vessel connection (fistula) used for dialysis grow stronger and work better. 34 adults with kidney failure on dialysis were randomly assigned to either do the exercises or receive standard care. The …

This study tested whether a home-based exercise program can reduce low back pain and improve quality of life in 30 adults receiving peritoneal dialysis for end-stage kidney disease. Participants followed a structured exercise routine while continuing their usual dialysis care. Re…

This study looked at 41 people on hemodialysis to see if doing resistance exercises at the beginning or end of a session affects blood pressure and well-being. Participants did lower-body exercises with sandbags three times a week for eight weeks. Researchers measured blood press…

This study looked at two ways to help people with diabetic nerve pain in their legs: high-intensity laser therapy and moderate aerobic exercise. Sixty adults with symptoms like numbness, tingling, or burning took part. The goal was to see which approach improves leg function and …

This study tests a program designed to increase living donor kidney transplants among Hispanic patients with end-stage renal disease. The program provides Spanish-language education and outreach by bicultural health workers. Researchers will compare transplant rates between Hispa…

This study tests whether advanced ultrasound techniques (2D and 3D speckle-tracking echocardiography) can detect early signs of heart muscle dysfunction in children aged 4 to 18 with end-stage kidney disease who have been on dialysis for at least a year. Researchers aim to see if…

This study looked at how dialysis patients personally feel about their treatment. Researchers asked 26 adults with kidney failure to rank 24 statements about their experience. The goal was to better understand their perspectives, not to test a new drug or device.

This study examines how the sleep aid YZJ-1139 behaves in people with severe kidney impairment compared to those with normal kidney function. Sixteen adults will receive a single 20 mg dose, and researchers will measure drug levels in the blood and urine, as well as any side effe…

This study looks at whether eating a single dose of dark chocolate (70% cocoa) changes blood flow to the kidneys and blood pressure, compared to white chocolate. Researchers will use ultrasound to measure kidney blood flow two hours after eating. The study includes 32 people: hea…

This study looks at how a single dose of the antibiotic levornidazole is processed by the body in people with moderate or severe kidney impairment compared to healthy volunteers. Researchers will measure drug levels in the blood and urine, and monitor safety. The goal is to under…

This completed study looked at how the drug opemalirsen (AZD2373) is processed in people with different levels of kidney function. Researchers gave a single injection to 35 adults, some with kidney impairment and some with healthy kidneys. The goal was to compare drug levels and …

This study looks at why people on dialysis for kidney failure often have dangerous heart rhythms. Researchers implanted a small heart monitor in 18 patients to track their heartbeats for up to three years. They also used CT scans and ultrasound to see if the dialysis procedure it…

This study looked at whether a special ultrasound check (called VExUS) can help doctors set the ideal dry weight for people on hemodialysis. The idea is that by spotting hidden fluid buildup, doctors can safely remove more fluid during dialysis to better control blood pressure. T…

This completed study looked at why some people develop scarring in their kidneys, including rare diseases like FSGS and a mysterious form of chronic kidney disease affecting farm workers. Researchers collected blood, urine, and kidney tissue from 537 participants to better unders…

This completed study looked at the safety of the diabetes drug JARDIANCE (empagliflozin) in 299 Korean adults with chronic kidney disease. Researchers tracked side effects and measured changes in a key kidney health marker (urine albumin-creatinine ratio) after 12 and 24 weeks of…

This study looked at 287 patients with acute kidney injury caused by tubular necrosis. Researchers measured two substances in urine (PIIINP and NGAL) to see if they could predict whether kidney function would return or if chronic kidney disease would develop. The goal is to find …

This completed observational study looked at 4500 patients admitted to internal medicine wards with heart failure, COPD, or chronic kidney disease. Researchers aimed to identify which other chronic conditions tend to cluster with these diseases, and how those clusters affect pati…

This study follows people over 75 with advanced chronic kidney disease to better understand their health and treatment paths. Researchers want to create a tool that predicts which patients are at high risk of dying soon after starting dialysis. The goal is to help patients, famil…

This study looks at whether gastric bypass surgery can protect the kidneys of people who are severely obese and have chronic kidney disease. Researchers measured kidney function before and one year after surgery in 14 patients. The goal is to see if the surgery improves the balan…

This study aims to create and test a new mathematical formula that estimates how much sodium (salt) people on peritoneal dialysis consume. The researchers will enroll 30 adults who have been on peritoneal dialysis for at least three months and have no remaining kidney function. I…

This study looked at how cannabidiol (CBD) interacts with tacrolimus, a drug used to prevent organ rejection in transplant patients. Researchers wanted to understand how to adjust doses for better health outcomes. The study involved 57 healthy adults and those with chronic kidney…

This study follows 211 people with IgA nephropathy who previously took a 6-9 month course of the steroid methylprednisolone in the TESTING trial. Researchers want to see if the steroid helped prevent end-stage kidney disease (needing dialysis or a transplant) over the long term. …

This completed study looked at 5000 older adults (66+) with low kidney function who started taking the antidepressant nortriptyline. Researchers compared those taking more than 10 mg per day to those taking exactly 10 mg per day to see if higher doses increased the chance of an e…

This study looked at 49 kidney transplant patients to see how two different induction therapies—thymoglobulin and basiliximab—affect B cells, a type of immune cell. Researchers compared the B cell profiles between the two groups and with data from patients who had chronic antibod…

This study looked at how the drug LY3502970 behaves in people with healthy kidneys compared to those with kidney problems. Researchers measured how much drug gets into the blood and how fast the body clears it. The goal is to understand if kidney impairment changes drug levels, w…

This study looked at two tools to help people with chronic kidney disease (CKD) stay healthier. One tool gave doctors a registry to track patients, and the other offered phone coaching from a health coach. The goal was to see if these approaches could lower blood pressure and imp…

This study looked at how well a new dialysis solution works compared to the usual one in people with kidney failure who are on peritoneal dialysis. Seven stable patients each tried both solutions during a single 4-hour session. The goal was to measure fluid removal and changes in…

This study looked at how two types of exercise affect bone health in people with chronic kidney disease. Sixty patients did either treadmill walking or resistance training for 6 months. Researchers measured bone turnover markers and bone density before and after the program to se…

This study looked at 166 older adults (65+) on hemodialysis to compare three types of vascular access: fistulas, grafts, and catheters. The goal was to see which option leads to fewer complications and better quality of life. Researchers tracked how many procedures were needed to…

This study followed more than 3,000 adults with moderate to advanced chronic kidney disease (CKD) for up to 5 years. Researchers collected health data and blood/urine samples to identify factors that lead to kidney failure, heart problems, and other complications. The goal was to…

This study examined whether starting a higher dose of two common antidepressants (venlafaxine and duloxetine) increases the risk of emergency visits, hospital stays, or death within 30 days in older adults with chronic kidney disease. Researchers analyzed health records from over…

This study tested a new way for doctors to discuss CPR with older, seriously ill patients and their families. Instead of the usual conversation, doctors followed a step-by-step guide that focused on the patient's values and explained why CPR might not help. The goal was to see if…

This completed observational study analyzed electronic health records of nearly 13,000 adults with chronic kidney disease in Spain to see how the drug dapagliflozin is used in everyday practice. Researchers looked at patient characteristics, lab results, and healthcare costs over…

This study tested a home education program called Explore Transplant@Home for nearly 1,000 patients with chronic kidney disease. The program mailed videos, postcards, and texts to teach about kidney transplant options, especially from living donors. The goal was to see if this ap…

This study tested a new device called EchoMark LP, which is implanted near a surgically created blood vessel connection (fistula) used for dialysis. The device works with a special ultrasound system (EchoSure) to measure blood flow, depth, and diameter of the fistula. The trial i…

This study followed 268 adults with end-stage kidney disease on dialysis. Each participant wore a Holter heart monitor for 7 days to track irregular heartbeats. Researchers then looked for links between those heart patterns and serious outcomes like sudden cardiac death, heart at…

This study looked at whether getting an islet transplant after a kidney transplant helps people with type 1 diabetes avoid kidney failure or death. Researchers reviewed data from 327 people in France who had a kidney transplant between 2000 and 2017. They compared those who also …

This study tested whether an AI tool that predicts the risk of kidney transplant failure within one year can improve conversations between patients, their families, and doctors. 76 adults with a functioning kidney transplant but declining kidney function took part. The goal was t…

This study looked at 58 adults on hemodialysis to understand how the mix of bacteria in their gut relates to waste products in their blood. Researchers measured different types of gut bacteria and chemicals they produce, like short-chain fatty acids and uremic toxins. The goal wa…

This study looked at whether a 12-week cycling program during hemodialysis can reduce heart muscle stress (called stunning) in adults with end-stage kidney disease. 111 participants either cycled or rested during their dialysis sessions. Researchers measured heart function with u…

This study looked at 88 adults with chronic kidney disease to see how their oral health changes at different stages. Researchers checked teeth, gums, saliva, and breath to find links with nutrition and inflammation. The goal is to understand if dental problems can worsen kidney d…

This study tested whether a program of videos and text messages (called KidneyTIME) helps people with kidney failure learn more about getting a kidney from a living donor. 422 adults who were already being evaluated for a kidney transplant took part. The study compared those who …

This study tested a program called SPIRIT that helps kidney dialysis patients and their families plan for end-of-life care. The program involved two face-to-face sessions to improve communication and decision-making. Researchers enrolled 852 patients and their surrogates from dia…

This study looked at whether starting dialysis at a specific time, based on a new mathematical formula, could help people with end-stage kidney disease live longer. 388 patients were randomly assigned to start dialysis either at an 'optimal' or 'late' time. Researchers tracked de…

This completed study from Aarhus University looked at how the urea cycle works in 10 people with end-stage kidney disease on dialysis. Participants received a 3-hour alanine infusion, and researchers measured urea production before and after dialysis. The goal was to understand u…

This completed study collected blood and urine samples from 240 people with ciliopathies—rare genetic disorders that often lead to kidney failure. Researchers analyzed these samples to find biological markers that could predict how the disease will progress. The goal is to develo…

This study looked at whether adjusting the amount of magnesium in the dialysis fluid could help keep blood magnesium levels in a healthy range for people with kidney failure on hemodialysis. Fifty-four adults took part in this pilot crossover trial. The goal was to gather informa…

This study looks at how the body processes HRS9531, an experimental diabetes drug, in people with different levels of kidney function. Researchers gave a single dose to 32 volunteers—some with healthy kidneys and some with mild impairment—and measured drug levels over time. The g…

This study looked at whether people on hemodialysis know how to safely disconnect themselves from the dialysis machine during an emergency, like a fire or power outage. Researchers tested 620 patients from multiple countries using a checklist. The goal was to see if patients coul…

This study looked at whether adding hands-on simulation training to standard classroom teaching helps nurses cause fewer problems when inserting needles into the arm access (arteriovenous fistula) of dialysis patients. About 9600 adults on chronic hemodialysis took part. The goal…

This study looked at how different levels of kidney function affect the way the drug enpatoran moves through the body. 34 adults with normal or impaired kidney function received a single dose of enpatoran. Researchers measured drug levels in the blood and monitored for side effec…

This completed study asked 140 people—including patients with chronic kidney disease, their families, healthcare professionals, and researchers—to identify the most important outcomes for self-managing the condition before dialysis is needed. Through multiple survey rounds, parti…

This study tested a communication tool called 'Best Case/Worst Case' for older adults with advanced kidney disease. Doctors were trained to discuss best, worst, and most likely outcomes for treatment options. The goal was to see if this approach helps patients receive more pallia…

This completed Phase 2 study investigated how the drugs dapagliflozin and balcinrenone, alone or together, affect the body's handling of water and salts in people over 50 with stage 3 chronic kidney disease. Over 28 days, 103 participants took daily pills to measure changes in ur…

This study looked at 2,500 kidney transplant patients to find out why some develop cancer. The main focus was on the immunosuppressive drugs that prevent organ rejection, which can also raise cancer risk. Researchers tracked patients from four regions in France over 10 years to i…

This study looked at how the drug LY3537031 moves through the body in people with different levels of kidney function. It included 31 adults with normal kidneys, kidney impairment, or end-stage kidney disease. The goal was to measure drug levels in the blood and how long it takes…

This study worked with community groups to screen Hispanic/Latinx adults for kidney disease and diabetes, then referred them to a primary care doctor. It also gave local clinics guidelines to help doctors screen and treat Hispanic and Black patients with diabetes. The goal was to…

This study looked at 395 adults on long-term dialysis to find out how often their blood pressure drops dangerously during treatment and what makes it more likely. Researchers collected information on patients' health history, medications, and dialysis settings. The goal is to hel…

This completed study analyzed electronic health records from over 6,500 patients in China who started taking finerenone for chronic kidney disease and type 2 diabetes. Researchers tracked kidney function, potassium levels, and side effects like high potassium. The goal was to see…

This study looked at how the amount of salt in the diet changes the effects of the diabetes drug ertugliflozin on blood pressure and kidney function. Overweight adults with type 2 diabetes followed either a low-salt or high-salt diet while taking the drug or a placebo. The goal w…

This pilot study tested a shared decision-making tool called the Donor Offer Plan (DOP) for people on the kidney transplant waiting list. 100 participants reviewed an online education module and discussed their donor preferences with a transplant nurse. The goal was to see if thi…

This study looked at whether the ratio of two types of blood cells (platelets and lymphocytes) can predict heart complications in people on long-term dialysis. Researchers followed 80 dialysis patients to see if this simple blood test ratio was linked to problems like hardening o…

This study looked at how a high-fat, high-calorie meal changes the amount of two drugs (zibotentan and dapagliflozin) in the blood of healthy people. Twenty-six adults took a single dose of the combined pill once after eating and once on an empty stomach. The goal was to see if f…

This study looked at data from 348 people with type 2 diabetes in Germany who use the myTherapy app. Researchers wanted to see how many had high levels of a protein called albumin in their urine, which is a sign of kidney damage. They also tracked how these levels changed over a …

This study looked at specific molecules in the blood of 180 people with chronic kidney disease (CKD) and 60 healthy volunteers. The goal was to see if these molecules could help diagnose CKD early or predict when a common treatment for anemia stops working. The researchers measur…

This study tested a single dose of the drug AZD4144 in 41 adults with severe kidney disease, end-stage kidney disease, and healthy volunteers. Researchers measured how the drug moves through the body and checked for side effects. The goal was to understand how kidney problems aff…

This study tested whether 3D ultrasound can accurately measure kidney and tumor volumes compared to standard CT or MRI scans. 53 adults with chronic kidney disease or kidney tumors participated. Researchers compared 3D ultrasound measurements to those from contrast-enhanced CT or…

This completed study looked at how the drug Advagraf (a form of tacrolimus) works in 45 adults who received a kidney transplant. The goal was to find better ways to dose the drug by measuring its levels in the blood right after transplant and three months later. Researchers compa…

This study tested whether home automation and remote monitoring can help elderly people (65+) with multiple chronic conditions live safely at home. Over 500 participants had their homes equipped with sensors that tracked health signs and sent alerts to doctors. The main goal was …

This study looks at how a single 5 mg dose of the blood thinner apixaban is processed in people with end-stage kidney disease who are on peritoneal dialysis, compared to people with normal kidney function. Researchers measured drug levels in the blood over time. The goal is to un…

This study measured certain inflammatory markers in the saliva and blood of 126 people with type 2 diabetes, some of whom also had kidney disease (diabetic nephropathy). The goal was to see if these markers differ based on gum health. Researchers hope to better understand the lin…

This completed Phase 1 study looked at how the drug avacopan is processed in 13 people with normal kidney function and those with end-stage renal disease requiring hemodialysis. Researchers measured drug levels in the blood and dialysis fluid after a single dose. The goal was to …

This study looked at whether giving African American adults with high blood pressure early access to genetic testing for a kidney disease risk gene (APOL1) could improve their care. Over 6,700 participants were randomly assigned to get their genetic results right away or later. T…

This study tested a program called DIAL-SDM that trains kidney doctors and coaches older patients (65+) with advanced kidney disease to have better conversations about dialysis. The goal was to see if the program was practical and acceptable. 102 patients, their caregivers, and 2…

This study tested a machine learning algorithm to predict if a patient being cared for at home would deteriorate. Researchers used data from over 500 patients to train the algorithm and compared its alerts to traditional vital sign alarms. The goal is to catch problems earlier an…

This study looked at 60 adults on long-term dialysis to see if the schedule of dialysis sessions affects blood flow to the legs. Some patients did standard 4-hour sessions three times a week, while others did shorter 2-hour sessions six times a week. The goal was to find out whic…

This completed study at Huashan Hospital looked at data from 778 adults on long-term hemodialysis. Researchers used artificial intelligence to build models that could give early warnings about inadequate dialysis and help diagnose complications like heart disease. The goal is to …

This study looked at data from 372 patients to see if a computer program could predict who would need to be readmitted to the hospital within 30 days. Researchers used information like age and health history to train the computer model. The goal was to find patterns that could he…

This study reviewed medical records of 139 people with advanced chronic kidney disease who had a heart attack. Researchers wanted to see if getting a coronary angiogram (a special X-ray of the heart arteries) soon after the heart attack was linked to living longer and needing dia…

This study tested whether having dialysis patients regularly fill out questionnaires about their symptoms and well-being helps them communicate better with their doctors and nurses. Over 3,900 adults on dialysis in Alberta and Ontario took part. The goal was to see if sharing the…

This study tested a program called ED GOAL that helps older adults with serious illnesses like heart failure or cancer discuss their end-of-life wishes with doctors and family, starting in the emergency department. Researchers enrolled 141 patients and measured whether the progra…

This early-stage study tested a new oral medicine, NNC0705-0001, in 116 healthy adults to see if it is safe and how the body handles it. The drug is being developed to treat chronic inflammation, which can lead to heart and metabolic diseases. Participants received either the dru…

This completed study analyzed data from 256 adults on maintenance hemodialysis to identify how symptoms group together. Researchers used statistical methods to find patterns in symptom co-occurrence and examined links with other health conditions and sex. The goal is to help doct…

This study looked at whether eating at different times during hemodialysis affects blood pressure stability and how well the treatment removes waste from the body. Researchers divided 40 adults with chronic kidney disease into groups that ate at set times or followed their usual …

This study aimed to find out how often people in Reunion Island start dialysis as an emergency and what social or medical factors lead to that. Researchers followed 233 adult patients beginning dialysis at local centers. The goal was to gather information to improve care and redu…

This study examined over 31,000 older adults (65+) with chronic kidney disease to see if starting a higher dose of the sleep medication trazodone (75-150 mg/day) leads to more serious events like hospital visits or death within 30 days compared to a lower dose (25-75 mg/day). The…

This study looked at 50 adults on maintenance hemodialysis to find the link between how fast fluid is removed (ultrafiltration rate) and sudden drops in blood pressure during treatment. The goal was to identify a safer threshold to prevent intradialytic hypotension. Researchers a…

This completed study examined blood vessel function in 101 elderly patients (65 and older) with chronic kidney disease who were not on dialysis. Researchers used ultrasound and other non-invasive tests to measure blood vessel health and looked for links to certain blood markers. …

This study tested whether a fast, concise presentation style called Pecha Kucha (20 slides, 20 seconds each) can improve how well hemodialysis patients follow their diet and fluid restrictions. Sixty patients took part, and researchers measured their attitudes toward diet therapy…

This completed study looked at 50 non-diabetic people with chronic kidney disease to see if the drug dapagliflozin changes the types of bacteria in their gut. Researchers measured gut bacteria diversity and related waste products in the blood before and after 12 weeks of treatmen…

This study surveyed 608 heart and kidney doctors to understand their awareness and use of a blood test called hsCRP, which measures inflammation. The goal was to learn what doctors think about inflammation's role in treating patients with heart disease, kidney disease, or heart f…

This study tested a program called ImPart-Multi, where a trained helper (lay navigator) coached Black patients with chronic kidney disease and their care partners on how to work together when making health decisions. 22 patients and their care partners joined, and patients comple…

This study looked at over 7,000 older adults (65+) with reduced kidney function who started taking the antidepressant citalopram. Researchers compared a 20 mg/day dose to a 10 mg/day dose to see if the higher dose increased the risk of serious events like hospitalization, emergen…

This study tested whether a personalized, home-based exercise program done via video calls could improve muscle function in people with moderate-to-severe chronic kidney disease (CKD) who are not on dialysis. Thirty-two sedentary adults aged 30-75 with CKD took part. They did com…

This study looked at how semaglutide, a diabetes medicine, affects the kidneys in people with type 2 diabetes and chronic kidney disease. 106 participants received either semaglutide or a placebo injection once a week for about a year. Researchers used MRI scans, blood and urine …

This study tested a Turkish version of the Respiratory Distress Observation Scale (RDOS) in 100 adult palliative care patients who cannot describe their breathing trouble. The scale uses eight physical signs like heart rate and restlessness to rate distress. The goal was to see i…

This study looked at whether it is safe to stop regularly checking blood flow in the arm veins used for dialysis. Instead, doctors would only treat problems when they cause symptoms during dialysis. The goal was to see if this approach reduces the number of procedures and medical…

This study tested a small, handheld device called the Nova Max Pro StatSensor that measures creatinine levels in the blood, a key marker of kidney function. The goal was to see if kidney transplant patients could use it reliably at home, compared to standard lab tests. One hundre…

This completed study looked at why people on chronic hemodialysis often have high blood pressure between sessions. Researchers measured weight gain, heart function, and blood chemicals in 32 stable dialysis patients. The goal was to understand the relative roles of fluid gain, ho…

This completed study looked at 1,100 older adults (65+) with advanced chronic kidney disease who started taking pramipexole, a drug for restless legs or Parkinson's. Researchers compared a very low starting dose (0.125 mg/day) to slightly higher doses (0.25 or 0.375 mg/day) to se…

This completed study looked at nearly 7,000 older adults (65+) with low kidney function who started taking the antidepressant sertraline. Researchers compared the safety of a 50 mg daily dose versus a 25 mg daily dose, tracking hospital visits, emergency department visits, or dea…

This study looked at over 12,000 older adults (age 66+) with low kidney function who started taking the antidepressant escitalopram. Researchers compared the safety of a 10 mg daily dose versus a 5 mg daily dose. The goal was to see if the higher dose led to more hospital visits,…

This study tested a prediction tool that uses routine lab results to estimate a patient's risk of kidney injury after heart surgery. Researchers looked at data from 2,500 adults who had heart surgery to see how well the tool worked. The goal is to help doctors catch kidney proble…

This study looked at how salt in the diet affects blood pressure in 130 adults with chronic kidney disease. Researchers measured a protein called uromodulin in urine to see if it predicts salt sensitivity. The goal was to understand why some patients' blood pressure rises more wi…

This completed study looked at whether special outreach programs—using transplant social workers and coordinators—can help Black and non-Black patients with chronic kidney disease get kidney transplants earlier and more fairly. Over 1,100 adults took part. The goal was to see if …

This study looked at 14,000 older adults (66+) with advanced chronic kidney disease who started taking tamsulosin. Researchers compared those on a higher dose (0.8 mg/day) to those on a lower dose (0.4 mg/day) to see if the higher dose led to more hospital visits or deaths within…

This study looked at how kidney doctors (nephrologists) think about choosing the right dialysis treatment for patients with kidney failure. Researchers interviewed 25 doctors across Belgium to understand their beliefs and attitudes. The goal is to find out if doctors' own views a…

This study looked at 100 kidney dialysis patients to understand why their blood vessels get damaged, raising heart risks. Researchers measured harmful substances called AGEs in the blood and skin, and checked for genetic factors. The goal was to learn how these substances interac…

This study looked at whether using a lower dialysate flow rate (300 ml/min instead of the usual 500 ml/min) affects how well dialysis cleans the blood, how quickly patients recover after treatment, and their overall quality of life. Eighty adults with end-stage kidney disease on …

This study looked at whether training community health workers to focus on kidney disease care, and teaching doctors about trauma-informed care, could improve quality of life for Black and Hispanic patients with advanced chronic kidney disease. The study involved 153 patients fro…

This study tested whether teaching dialysis staff and providing support to patients could reduce episodes of dangerously low blood pressure during treatment. Over 1,400 patients across multiple clinics took part. The goal was to make dialysis sessions safer and more stable.

This study looked at whether a tailored program of protein supplements and exercise can increase muscle protein production in people with advanced chronic kidney disease (CKD) who are not yet on dialysis. Researchers compared these patients to healthy adults to see how their bodi…

This study tested a computer program that acts like a virtual doctor to teach people with advanced chronic kidney disease about kidney transplants. 148 patients took part. The goal was to see if talking with this virtual agent could increase their interest in considering a transp…

This study looked at how common prediabetes is in people with end-stage kidney disease who are on dialysis. Researchers screened 262 adult dialysis patients who had never been diagnosed with diabetes or prediabetes. The goal was to find out how many had prediabetes, which can inc…

This early-stage study tested a single dose of the antibiotic TQD3524 in 48 people with varying degrees of kidney function. The goal was to see how the drug moves through the body and is removed, especially by the kidneys, and to check for any safety issues. The study did not aim…

This study examined whether a marker of inflammation called interleukin-6 (IL-6) is linked to thyroid hormone problems in people with chronic kidney disease on dialysis. Researchers analyzed blood samples from 65 stable dialysis patients. The goal was to see if higher IL-6 levels…

This study looked at how the body processes an experimental antibiotic called TQD3606 in people with different levels of kidney function. 32 adults received a single dose, and researchers measured drug levels in blood and urine. The goal was to understand safety and drug clearanc…

This completed Phase 1 trial looked at how colestilan, a drug for high phosphate levels in kidney disease, affects the body's processing of candesartan, a blood pressure medication. Eighteen healthy men took candesartan alone or with colestilan at different times. The goal was to…

This study used advanced MRI scans to look at the hearts of 276 people with chronic kidney disease, including those on dialysis. The goal was to identify different types of heart damage and link them to patient outcomes. No new treatment was tested; instead, researchers aimed to …

This study measured how often teenagers develop chronic kidney disease after having heart surgery as young children. Researchers collected blood and urine samples from 120 teens aged 10 to 15 during their regular heart check-ups. The goal was to find out how common kidney damage …

This study looked at whether a simple urine test could predict scarring in kidney transplants, instead of using a needle biopsy. Researchers measured certain genetic markers in urine cells from 300 kidney transplant recipients over the first year after transplant. The goal was to…

This early-stage study tested a single dose of the experimental drug KBP-5074 in 11 people with severe chronic kidney disease, including some on dialysis. The main goal was to check safety and how the drug moves through the body. No treatment benefits were measured; the study onl…

This study tested whether giving an education booklet to people with stage 3 or 4 chronic kidney disease helps them follow their treatment plan, take care of themselves, and feel better overall. 119 patients participated, and researchers measured changes using standard questionna…

This completed study in Greece observed 125 patients with chronic kidney disease (on or off dialysis) or heart failure who were taking sodium zirconium cyclosilicate for high potassium levels. Researchers collected data on patient characteristics and treatment patterns over six m…

This study looked at how a class of diabetes drugs called SGLT2 inhibitors changes kidney function in people with chronic kidney disease (CKD). Researchers compared 60 patients with and without diabetes to see if the drug affects their estimated glomerular filtration rate (eGFR) …

This study tested a program called the Live Donor Champion Program, which trains a friend or family member to help a kidney patient find a live donor. The program was offered to 111 patients on the kidney transplant waitlist. Researchers wanted to see if the program could be succ…

This completed study in 49 veterans with early chronic kidney disease (CKD) tested whether diuretics (water pills) can reduce fluid overload and improve heart health. Researchers measured changes in heart stress markers and symptoms like fatigue after 4 weeks of treatment. The go…

This study looked at whether analyzing the fluid used to preserve kidneys on a LifePort® machine could help predict how well the kidney will work after transplant. Researchers measured chemicals in the fluid and compared them to early kidney function in 40 recipients. The goal is…

This study looked at how gut bacteria in people with chronic kidney disease (CKD) produce harmful toxins that build up in the body. Researchers collected stool samples from 20 patients with advanced CKD and placed them into an artificial intestine to test whether probiotics could…

This study looks at how pancreas-kidney transplantation changes bile acids and gut-related metabolism in people with type 1 diabetes and kidney disease. Researchers will measure bile acid levels and glucose responses in 50 transplant patients, comparing them to kidney-only transp…

This study tested an electronic alert system that reminds doctors to screen, monitor, and refer patients with chronic kidney disease (CKD). It involved 66 primary care centers in Stockholm, covering about 780,000 people. The goal was to see if the system improves detection and ma…

This study used a special MRI technique to measure phosphate and ATP (energy) levels inside muscle cells of 11 kidney dialysis patients during a 4-hour session. The goal was to find out whether phosphate removed during dialysis comes from inside cells. If it does, it might explai…

This early-stage study tested the safety and tolerability of a new drug called KBP-5074 in 26 adults, including healthy volunteers and those with mild to moderate kidney impairment. Researchers measured how the drug moves through the body and its effects on blood pressure and pot…

This study looked at whether certain gene variants (APOL1) are linked to advanced chronic kidney disease (stage 4) in Afro-Caribbean adults living in Guadeloupe. Researchers analyzed blood samples from 88 participants to find how common these gene variants are. The goal was to be…

This study followed nearly 6,000 people with kidney disease from around the world. Researchers collected routine test results like kidney function and protein in urine to better understand how the disease progresses. The goal was to gather information, not to test a new treatment…

This study tested a patient-friendly website and printouts to help kidney transplant candidates compare transplant centers. Researchers wanted to see if the new format helped people understand which centers accept patients like them. A total of 268 adults waiting for a kidney tra…

This study tested a short online course for Syrian nurses to improve their ability to detect and manage chronic kidney disease (CKD). Thirty nurses from kidney, heart, and hormone units took seven short modules on their phones or computers over four weeks. The goal was to see if …

This study surveyed 1,500 Chinese heart and kidney specialists to understand their awareness and perceptions of systemic inflammation in patients with both atherosclerotic cardiovascular disease and chronic kidney disease. The goal was to learn how doctors currently identify and …

This completed study from University Hospital Freiburg looked back at 490 patients with liver cirrhosis and signs of chronic kidney disease who were treated for hepatorenal syndrome. Researchers compared how well patients with and without pre-existing kidney disease responded to …

This completed study observed 178 patients with advanced cancer, chronic kidney failure, or chronic lung diseases to assess their palliative care needs and survival factors. Researchers used two scoring tools to evaluate when and how to best introduce palliative care alongside re…

This completed pilot study tested whether the HemoCept device can accurately measure fluid removal during dialysis in 26 adults with end-stage kidney disease. Researchers compared device readings before and after dialysis to changes in dry weight. The goal is to see if this non-i…

This study reviewed medical records of 345 adults to see if primary care doctors referred patients with chronic kidney disease to a kidney specialist at the right time and with the right treatment. The goal was to understand how well current referral practices work, not to test a…

This study looked at how the drug zibotentan is absorbed and cleared by the body in 30 healthy adults, including both non-Asian and Japanese participants. It was a phase 1 trial, meaning it was an early step to gather safety and drug-level information. The study did not aim to tr…

This study looked at 225 adults with a rare, inherited form of kidney disease to find the genetic causes. Participants had chronic kidney failure and often had a family history of gout. Researchers tested for known gene mutations and searched for new ones in families without a cl…

This study tested whether having a clinical pharmacist work alongside doctors in a hospital ward could reduce medication errors in patients with kidney disease. Researchers followed 160 adults with reduced kidney function, comparing usual care, doctor education, and active pharma…

This study looked at whether a special planning tool, called a POST form, helps older adults (65+) get the medical care they prefer at the end of life. Researchers worked with 389 people, including those with dementia, to see if their treatment matched their wishes. The goal was …

This study looked at small pieces of donor kidney tissue to see if certain substances could predict how well the organ would work after transplant. Researchers tested blood, urine, and biopsy samples from 24 kidney transplant recipients. The goal was to find early signs of organ …

This pilot study tested a smartphone-based tool called SMART-HABITS in 47 adults with chronic kidney disease and high blood pressure. The tool provided reminders, feedback, and educational resources through text messages or an app, and linked to wearable devices like Fitbits and …

This study looked at 319 patients who needed dialysis for severe acute kidney injury. Researchers collected their medical information to identify risk factors for developing chronic kidney disease. The goal was to create a scoring system that helps doctors decide which patients w…

This completed Phase 1 study looked at how different levels of kidney function affect the way the body processes a single dose of the drug AZD6234. Researchers compared 24 adults with various degrees of kidney impairment to healthy volunteers. The goal was to understand how the d…

This completed trial tested whether an on-screen electronic alert in the doctor's computer system could increase testing for chronic kidney disease (CKD) in people with type 2 diabetes. About 400 patients who hadn't had a key kidney test in the past year took part. The alert remi…

This study looked at how doctors in seven Central Eastern European countries prescribe dapagliflozin for chronic kidney disease in routine care. Researchers reviewed medical records of about 1,090 adults to understand who gets the drug and what happens over the next year. The goa…

This completed Phase 1 study looked at how the drug MK-5684 behaves in the body of men with severe kidney disease or end-stage renal disease compared to healthy men. Twenty-four participants received a single dose, and researchers measured drug levels in the blood over time. The …

This pilot study tested a device called HemoCept in 12 adults with end-stage kidney disease on dialysis. The goal was to see if the device could accurately track changes in hydration during fluid removal. Researchers compared device readings to changes in dry weight before, durin…

This study looked at how the drug BMS-986278 behaves in people with normal kidneys, severe kidney disease, or kidney failure on dialysis. 27 adults took a single dose to measure drug levels and check for side effects. The goal was to gather safety information, not to treat the di…

This completed study tracked over 1,000 chronic kidney disease patients taking Forxiga in everyday medical practice. The main goal was to see how often side effects occur and what factors might increase risks. The study did not test whether the drug works, but rather gathered saf…

This study reviewed medical records from over 91,000 adults in Spain to understand how chronic kidney disease (CKD) is diagnosed and treated in routine practice. Researchers looked at lab results, medications, and heart/kidney events over time. The goal was to see how often kidne…

This study looked at 167 adults with chronic kidney disease on either hemodialysis or peritoneal dialysis to compare their blood levels of calcium, phosphorus, and other minerals linked to bone health. The goal was to see if one dialysis method is associated with fewer mineral an…

This study looked at how certain heart-related proteins change in the blood of 26 adults with end-stage kidney disease during two types of dialysis. The goal was to understand the patterns of these proteins, which may help doctors better monitor heart health in dialysis patients.…

This completed study screened over 8,400 Brazilian adults with known risk factors for chronic kidney disease (CKD) using a portable creatinine test. Participants were randomly selected from five regions. Those with abnormal results were referred for lab confirmation and follow-up…

This study tested whether giving dialysis facilities regular reports on their performance could help reduce racial differences in who gets placed on the kidney transplant waiting list. Over 56,000 patients at about 750 dialysis centers across the U.S. took part. The goal was to s…

This study looked at whether vitamin D levels in the blood are related to early signs of artery hardening (atherosclerosis) in people on dialysis. Researchers measured vitamin D and used ultrasound to check artery thickness in 90 adults with kidney failure. The goal was to see if…

This pilot study looked at how hemodialysis changes the electrical properties of skin and muscle in 18 adults on chronic dialysis. Researchers measured these changes to better understand fluid shifts during treatment. The goal was to gather knowledge, not to test a new treatment.

This study tested whether sending digital letters to patients with chronic kidney disease and their family doctors could increase the use of recommended medications. Over 28,000 adults in Denmark took part. The goal was to see if simple reminders through the official government e…

This completed study looked at over 12,000 older adults (66+) with low kidney function who started taking lorazepam. Researchers compared higher doses (1-4 mg/day) to lower doses (0.5-1 mg/day) to see if there was a greater risk of hospitalization, emergency visits, or death with…

This study analyzed electronic medical records of nearly 920,000 Canadian adults to see how the COVID-19 pandemic affected primary care for chronic conditions like diabetes, heart failure, and depression. Researchers compared care before and during the pandemic, looking at visits…

This study tested whether trained transplant navigators could help kidney failure patients complete the steps needed to get a kidney transplant. About 167 adults on dialysis were assigned to either a navigator or usual care. The navigator provided tailored help and information to…

This study looked at whether the diabetes drug metformin can be used safely in people with type 2 diabetes who also have kidney disease. Researchers gave increasing doses of metformin to 82 patients with different stages of kidney failure and measured the drug levels in their red…