New drug combo shows promise for kidney disease in small trial
NCT ID NCT05834738
First seen Jun 27, 2026 · Last updated Jul 21, 2026 · Updated 2 times
Summary
This study tested whether adding the drug atrasentan to standard care (including SGLT2 inhibitors) can reduce protein in the urine of people with IgA nephropathy, a kidney disease. 54 adults with biopsy-confirmed IgA nephropathy participated. The main goal was to see if atrasentan lowers proteinuria more than placebo over 12 weeks.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Chung-Ang University College
Seoul, Seoul, 06973, South Korea
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Dong-A University Medical Center (Dong-A University Hospital)
Busan, Busan, 49201, South Korea
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Fides Clinical Research
Atlanta, Georgia, 30342, United States
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Hallym University Sacred Heart Hospital
Anyang-si, Gyeonggi-do, 14068, South Korea
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Hopsital Sultanah Aminah Johor Bharu (HSAJB) - Bangunan Bakawali Heodialysis Centre
Johor Bahru, Johor Darul Takzim, 80100, Malaysia
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Hospital 12 de Octubre
Madrid, 28041, Spain
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Hospital Clinico Universitario
Valencia, 46010, Spain
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Hospital Raja Permaisuri Bainun (HRPB)
Ipoh, Perak, 30450, Malaysia
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Hospital Ribera Polusa
Lugo, 27004, Spain
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Hospital Torrecardenas
Almería, 04009, Spain
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Hospital Universitario De Getafe (HUG)
Madrid, 28009, Spain
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Hospital Virgen Macarena
Seville, 41009, Spain
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Hospital das Clinicas da Faculdade de Medicina da USP
São Paulo, São Paulo, 05403-000, Brazil
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Hospital del Mar
Barcelona, 08003, Spain
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Hospital del Vall d´Hebron
Barcelona, 08035, Spain
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Monash Health- Monash Medical Centre
Melbourne, Victoria, 3168, Australia
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NANI Research
Oak Brook, Illinois, 60523, United States
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NUPEC Cardio
Belo Horizonte, Minas Gerais, 30220-140, Brazil
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Prince of Wales Hospital
Sydney, New South Wales, 2031, Australia
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Santa Casa de Misericordia de Porto Alegre
Porto Alegre, Rio Grande do Sul, 90035-074, Brazil
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Soon Chun Hyang Central Medical Center (SCHMC) - Soon Chun Hyang University Hospital
Cheonan, Chungnam-Do, 31151, South Korea
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Sunshine Hospital
St Albans, Victoria, 3021, Australia
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The St. George Hospital
Kogarah, New South Wales, 2217, Australia
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Tufts Medical Center
Boston, Massachusetts, 02111, United States
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Universidade Federal de Sao Paulo
São Paulo, São Paulo, 04038-002, Brazil
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Universiti Kebangsaan Malaysia (UKM) - Medical Centre (Pusat Perubatan) (Hospital Canselor Tuanku Muhriz (HCTM))
Cheras, Kuala Lumpur, 56000, Malaysia
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University Malaya Medical Centre
Kuala Lumpur, Kuala Lumpur, 59100, Malaysia
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University of Alabama at Birmingham (UAB) - The Kirklin Clinic (TKC) - Nephrology Clinic
Birmingham, Alabama, 35233, United States
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University of North Carolina at Chapel Hill - Nephrology and Hypertension
Chapel Hill, North Carolina, 27599, United States
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University of Pennsylvania
Philadelphia, Pennsylvania, 19104, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Mapping the Real-World treatment landscape for IgA nephropathy
- A simple test could forecast kidney disease progression
- Experimental drug aims to protect kidneys in inflammatory diseases
- Scientists probe kidney cell metabolism to unlock secrets of ANCA vasculitis
- Immune cell therapy takes on kidney disease
- Steroids for kidney disease: do they prevent failure Long-Term?