Can a simple pill shield dialysis Patients' hearts?

NCT ID NCT03020303

First seen Aug 13, 2026 · Last updated Aug 14, 2026 · Updated 1 time

Summary

This trial tests whether spironolactone, a pill already used to protect the heart in other patients, can reduce heart failure and heart-related deaths in people on dialysis. Participants take either spironolactone or a placebo daily. The study aims to see if this treatment is both safe and effective for this high-risk group.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
spironolactone 25 mg tablet taken once daily
What this could lead to
If effective, spironolactone could become a standard, low-cost treatment to reduce heart failure and heart-related deaths in people on dialysis.
What could go wrong
The trial is large but still experimental for this population; spironolactone may raise potassium levels, which can be dangerous, and it may not prove beneficial in dialysis patients.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • ACE Hospital Une

    Pune, Maharashtra, 411004, India

  • AIMS Hospital Mumbai

    Dombivali, Maharashtra, 421203, India

  • Aberdeen Royal Infirmary

    Aberdeen, AB23 2ZN, United Kingdom

  • Aditya Birla Hospital

    Pune, Maharashtra, 411033, India

  • Apollo Hospitals

    Chennai, Tamil Nadu, 600081, India

  • Ashirwad Hospital Mumbai

    Mumbai, Maharashtra, 421004, India

  • AsterMedCity

    Kochi, Kerala, 682027, India

  • Beijing Miyun District Hospital

    Beijing, China

  • Beijing Tongren Hospital, Capital Medical University

    Beijing, China

  • Belfast City Hospital

    Belfast, BT9 7AB, United Kingdom

  • Birmingham Hospitals

    Birmingham, United Kingdom

  • CHU de Quebec L'Hotel-Dieu de Quebec

    Québec, Quebec, G1R 2J6, Canada

  • CIUSSS Hopital Maisonneuve- Rosemont

    Montreal, Quebec, H1T 2M4, Canada

  • Canberra Hospital

    Garran, Australian Capital Territory, 2605, Australia

  • Canimel Center

    Melo, Departamento de Cerro Largo, Uruguay

  • Cape Breton Regional Hospital

    Sydney, Nova Scotia, Canada

  • Caritas Hospital

    Kottayam, Kerala, 686630, India

  • Cedina Center

    Montevideo, Uruguay

  • Centre Hospitalier de l'Universite de Montreal (CHUM)

    Montreal, Quebec, H2W 1T8, Canada

  • Centro de Asistencia del Sindicato Medico del Uruguay-Institucion de Asistencia medica Privada (CASMU-IAMPP)

    Montevideo, Uruguay

  • Churchill Hospital

    Headington, Oxford, OX3 7LE, United Kingdom

  • City Hospital

    Nottingham, Nottingham, NG5 1PB, United Kingdom

  • Clinefnorte CIA Ltda

    Quito, Pichincha, 170303, Ecuador

  • Concord Repatriation General Hospital

    Concord, New South Wales, 2139, Australia

  • Daisy Hill Hospital

    Newry, Down, BT35 8DR, United Kingdom

  • Dhadiwal Hospital

    Nashik, Maharashtra, 422002, India

  • Dunedin Hospital

    Dunedin, 9016, New Zealand

  • East Kent Canterbury Hospital

    Canterbury, Kent, CT1 3NG, United Kingdom

  • Emergency General Hospital

    Beijing, China

  • Epsom St. Helier

    Carshalton, United Kingdom

  • Father Muller Medical College

    Mangalore, India

  • Faw General Hospital of Jilin Province

    Changchun, China

  • Felicio Rocho Foundation - Hospital Felicio Rocho

    Belo Horizonte, Minas Gerais, 30110934, Brazil

  • Foothills Hospital

    Calgary, Alberta, T2N 2T9, Canada

  • Fortis Hospitals

    Bengaluru, Karnataka, 560076, India

  • Fundacao Hospitalar Sao Francisco de Assis

    Belo Horizonte, Minas Gerais, 31110580, Brazil

  • Fundacao Pro-Rim

    Boa Vista, Joinville, 89227680, Brazil

  • Gansu Baoshihua Hospital

    Lanzhou, China

  • General Hospital of Ningxia Medical University

    Yinchuan, Ningxia, China

  • General Hospital of Xuzhou Mining Group

    Xuzhou, China

  • Government Rajaji Hospital, Madurai

    Madurai, India

  • Hacettepe University Hospitals Hemodialysis Center

    Ankara, Turkey (Türkiye)

  • Hawkes Bay Hospital

    Hastings, 4120, New Zealand

  • Health Sciences North Research Institute

    Greater Sudbury, Ontario, P3E 5J1, Canada

  • Hopital du Sacre-Coeur de Montreal

    Montreal, Quebec, H4J 1C5, Canada

  • Hospital Alemao Oswaldo Cruz

    Bela Vista, Brazil

  • Hospital Ampang

    Setapak, 53200, Malaysia

  • Hospital Arquidiocesano Consul Carlos Reneaux

    Brusque, Santa Catarina, 8835404, Brazil

  • Hospital Kajang

    Kajang, Selangor, 43000, Malaysia

  • Hospital Kuala Lumpur

    Kuala Lumpur, Kuala Lumpur, 42896, Malaysia

  • Hospital Pakar Sultanah Fatimah

    Muar town, Johor, Malaysia

  • Hospital Pulau Pinang

    George Town, Pulau Pinang, 10990, Malaysia

  • Hospital Sultanah Aminah, Johor Bahru

    Johor Bahru, Johor, 80100, Malaysia

  • Hospital Sultanah Nur Zahirah Kuala Terengganu

    Kuala Terengganu, Kuala Terengganu, 33158, Malaysia

  • Hospital Taiping

    Taiping, Perak, 34000, Malaysia

  • Hospital Tengku Ampuan Afzan, Kuantan

    Kuantan, 29142, Malaysia

  • Hospital Tengku Ampuan Rahimah Klang

    Klang, Selangor, 41200, Malaysia

  • Hospital Tuanku Jaafar, Seremban

    Seremban, 25167, Malaysia

  • Hospital de Clinicas de Porto Alegre

    Porto Alegre, Rio Grande do Sul, 90035-903, Brazil

  • Huai'an First Peoples Hospital

    Huai'an, China

  • Humber River Health

    Toronto, Ontario, Canada

  • Instituto Pro Renal Brazil

    Curitiba, Paraná, 80440-020, Brazil

  • Irmandade da Santa Casa de Misericordia de Porto Alegre -ISCMPA

    Bairro Santa Teresa, Porto Alegre, 90020090, Brazil

  • K S Hegde Medical Academy

    Mangaluru, Karnataka, 575018, India

  • Kelowna General Hospital

    Kelowna, British Colombia, V1Y 1T2, Canada

  • Kings College Hospital

    London, London, SE5 9RS, United Kingdom

  • Leicester General Hospital

    Leicester, United Kingdom

  • Liverpool University Hospitals

    Liverpool, United Kingdom

  • Madras Medical College Chennai

    Park Town, Chennai, 600003, India

  • Medical School of Botucatu of the Paulista State University - UNESP

    Rubião Júnior, Botucatu, 18618-687, Brazil

  • Memorial Service Hospital

    Istanbul, Turkey (Türkiye)

  • Monash Health

    Clayton, Victoria, 3168, Australia

  • Nanjappa Hospitals Shimoga

    Shimoga, Karnataka, 577201, India

  • Narayana Hrudayalaya Limited

    Bangalore, Karnataka, 560099, India

  • National Health and Education Society

    Mumbai, Maharashtra, 400016, India

  • National Kidney and Transplant Institute

    Quezon City, Manila, 1101, Philippines

  • Nefromedic SA

    Quito, Pichincha, 170601, Ecuador

  • Ninewells Hospital

    Dundee, DD1 9SY, United Kingdom

  • Nizams Institute of Medical Sciences

    Hyderabad, Telangana, 500082, India

  • North Shore Hospital

    Takapuna, Auckland, 0620, New Zealand

  • Northern Beaches Hospital

    Frenchs Forest, New South Wales, 2086, Australia

  • Osmangazi University

    Eskişehir, Turkey (Türkiye)

  • Osmania General Hospital

    Hyderabad, Telegana, 500012, India

  • Ottawa Hospital Research Institute

    Ottawa, Ontario, K1Y 4E9, Canada

  • PROCARDIO Clinica Cardiologica

    Blumenau, South Carolina, 89010500, Brazil

  • Palmerston North Hospital

    Palmerston North, 4442, New Zealand

  • Peking University First Hospital

    Beijing, Beijing Municipality, China

  • Peking University Peoples Hospital

    Beijing, Beijing Municipality, China

  • Penticton Regional Hospital

    Penticton, British Columbia, Canada

  • Peoples Hospital of Yuxi City

    Yuxi, China

  • Peoples Hospital of Zhongwei

    Zhongwei, China

  • Philippines General Hospital

    Ermita, Manila, 1000, Philippines

  • Praxis Pesquisa Medica S/S

    Santo André, São Paulo, 09090 790, Brazil

  • Princess Alexandra Hospital

    Woolloongabba, Queensland, 4102, Australia

  • Queen Elizabeth II Health Science Centre

    Halifax, Nova Scotia, B3H 1V7, Canada

  • Queen Elizabeth University Hospital

    Glasgow, Glasgow, G51 4TF, United Kingdom

  • Queens University at Kingston General Hospital, Division of Nephrology

    Kingston, Ontario, Canada

  • Royal Brisbane Women's Hospital

    Herston, Queensland, 4029, Australia

  • Royal Derby Hospital

    Derby, DE22 3NE, United Kingdom

  • Royal Inland Hospital

    Kamloops, British Colombia, V2C 2T1, Canada

  • Royal North Shore Hospital

    Wahroonga, New South Wales, 2076, Australia

  • Royal Stoke University Hospital

    Stoke-on-Trent, United Kingdom

  • SEDIC Center

    Montevideo, Montevideo Department, 11800, Uruguay

  • Salford Royal Hospital

    Salford, Salford, M6 8HD, United Kingdom

  • Santa Casa de Misericordia de Belo Horizonte

    Santa Efigênia, Belo Horizonte, 30150221, Brazil

  • Santa Casa de Misericordia de Ponta Grossa

    Ponta Grossa, Brazil

  • Santa Casa de Misericordia de Votuporanga

    Votuporanga, São Paulo, 15500003, Brazil

  • Servico Ubaense de Nefrologia Ltda

    Ubá, Minas Gerais, 36500008, Brazil

  • Seven Star Hospital

    Nagpur, India

  • Shanghai Tongji Hospital

    Shanghai, China

  • Shanxi Provincial Peoples Hospital

    Shanxi, China

  • Shuyang County Hospital of Traditional Chinese Medicine

    Suqian, China

  • Sihong County Fenjinting Hospital

    Suqian, China

  • Sociedade Hospitalar Angelina Caron

    Campina Grande do Sul, Paraná, 83430000, Brazil

  • South Tees James Cook Hospital

    Middlesbrough, United Kingdom

  • Southmead Hospital

    Bristol, Bristol, BS10 5NB, United Kingdom

  • St. Joseph's Healthcare

    Hamilton, Ontario, L8N 4A6, Canada

  • St. Josephs, Toronto

    Toronto, Ontario, M6R 1B5, Canada

  • St. Michael's Hospital

    Toronto, Ontario, M5B 1W8, Canada

  • St. Pauls Hospital

    Vancouver, British Colombia, V6Z 1Y6, Canada

  • Sunshine Coast University Hospital

    Birtinya, Queensland, 4575, Australia

  • Sydney Adventist Hospital

    Wahroonga, New South Wales, 2076, Australia

  • The Central Hospital of Enshi Tujia and Miao Autonomous Prefecture

    Enshi, China

  • The First Affiliated Hospital of Baotou Medical College

    Baotou, China

  • The First Hospital of Kunming

    Kunming, China

  • The Royal London Hospital

    London, London, E1 2ES, United Kingdom

  • The Sir Mortimer B. Davis Jewish General Hospital

    Montreal, Quebec, Canada

  • Tianjin Fifth Central Hospital

    Tianjin, China

  • Tianjin Third Central Hospital

    Tianjin, China

  • Tongiao City Hospital

    Tongliao, China

  • Ulster Hospital

    Dundonald, Belfast, BT16 1RH, United Kingdom

  • University Hospital of Whales Health Park

    Cardiff, Cardiff, CF14 4XW, United Kingdom

  • University Malaya Medical Centre (UMMC)

    Kuala Lumpur, Kuala Lumpur, 59100, Malaysia

  • University of Alberta

    Edmonton, Alberta, T6G 2G3, Canada

  • Victoria Hospital

    London, Ontario, N6A 5W9, Canada

  • Vijaya Hospital

    Chennai, Tamil Nadu, 600026, India

  • Waikato Hospital

    Hamilton, Waikato Region, 3204, New Zealand

  • Western Health - Sunshine Hospital

    Saint Albans, Victoria, 3021, Australia

  • Whangarei Hospital

    Whangarei, 0148, New Zealand

  • Xinxiang First Peoples Hospital

    Xinxiang, China

  • Yichuan County Traditional Chinese Medicine Hospital

    Luoyang, China

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