Can a simple pill shield dialysis Patients' hearts?
NCT ID NCT03020303
First seen Aug 13, 2026 · Last updated Aug 14, 2026 · Updated 1 time
Summary
This trial tests whether spironolactone, a pill already used to protect the heart in other patients, can reduce heart failure and heart-related deaths in people on dialysis. Participants take either spironolactone or a placebo daily. The study aims to see if this treatment is both safe and effective for this high-risk group.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- spironolactone 25 mg tablet taken once daily
- What this could lead to
- If effective, spironolactone could become a standard, low-cost treatment to reduce heart failure and heart-related deaths in people on dialysis.
- What could go wrong
- The trial is large but still experimental for this population; spironolactone may raise potassium levels, which can be dangerous, and it may not prove beneficial in dialysis patients.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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ACE Hospital Une
Pune, Maharashtra, 411004, India
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AIMS Hospital Mumbai
Dombivali, Maharashtra, 421203, India
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Aberdeen Royal Infirmary
Aberdeen, AB23 2ZN, United Kingdom
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Aditya Birla Hospital
Pune, Maharashtra, 411033, India
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Apollo Hospitals
Chennai, Tamil Nadu, 600081, India
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Ashirwad Hospital Mumbai
Mumbai, Maharashtra, 421004, India
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AsterMedCity
Kochi, Kerala, 682027, India
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Beijing Miyun District Hospital
Beijing, China
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Beijing Tongren Hospital, Capital Medical University
Beijing, China
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Belfast City Hospital
Belfast, BT9 7AB, United Kingdom
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Birmingham Hospitals
Birmingham, United Kingdom
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CHU de Quebec L'Hotel-Dieu de Quebec
Québec, Quebec, G1R 2J6, Canada
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CIUSSS Hopital Maisonneuve- Rosemont
Montreal, Quebec, H1T 2M4, Canada
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Canberra Hospital
Garran, Australian Capital Territory, 2605, Australia
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Canimel Center
Melo, Departamento de Cerro Largo, Uruguay
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Cape Breton Regional Hospital
Sydney, Nova Scotia, Canada
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Caritas Hospital
Kottayam, Kerala, 686630, India
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Cedina Center
Montevideo, Uruguay
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Centre Hospitalier de l'Universite de Montreal (CHUM)
Montreal, Quebec, H2W 1T8, Canada
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Centro de Asistencia del Sindicato Medico del Uruguay-Institucion de Asistencia medica Privada (CASMU-IAMPP)
Montevideo, Uruguay
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Churchill Hospital
Headington, Oxford, OX3 7LE, United Kingdom
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City Hospital
Nottingham, Nottingham, NG5 1PB, United Kingdom
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Clinefnorte CIA Ltda
Quito, Pichincha, 170303, Ecuador
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Concord Repatriation General Hospital
Concord, New South Wales, 2139, Australia
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Daisy Hill Hospital
Newry, Down, BT35 8DR, United Kingdom
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Dhadiwal Hospital
Nashik, Maharashtra, 422002, India
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Dunedin Hospital
Dunedin, 9016, New Zealand
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East Kent Canterbury Hospital
Canterbury, Kent, CT1 3NG, United Kingdom
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Emergency General Hospital
Beijing, China
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Epsom St. Helier
Carshalton, United Kingdom
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Father Muller Medical College
Mangalore, India
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Faw General Hospital of Jilin Province
Changchun, China
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Felicio Rocho Foundation - Hospital Felicio Rocho
Belo Horizonte, Minas Gerais, 30110934, Brazil
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Foothills Hospital
Calgary, Alberta, T2N 2T9, Canada
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Fortis Hospitals
Bengaluru, Karnataka, 560076, India
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Fundacao Hospitalar Sao Francisco de Assis
Belo Horizonte, Minas Gerais, 31110580, Brazil
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Fundacao Pro-Rim
Boa Vista, Joinville, 89227680, Brazil
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Gansu Baoshihua Hospital
Lanzhou, China
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General Hospital of Ningxia Medical University
Yinchuan, Ningxia, China
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General Hospital of Xuzhou Mining Group
Xuzhou, China
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Government Rajaji Hospital, Madurai
Madurai, India
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Hacettepe University Hospitals Hemodialysis Center
Ankara, Turkey (Türkiye)
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Hawkes Bay Hospital
Hastings, 4120, New Zealand
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Health Sciences North Research Institute
Greater Sudbury, Ontario, P3E 5J1, Canada
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Hopital du Sacre-Coeur de Montreal
Montreal, Quebec, H4J 1C5, Canada
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Hospital Alemao Oswaldo Cruz
Bela Vista, Brazil
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Hospital Ampang
Setapak, 53200, Malaysia
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Hospital Arquidiocesano Consul Carlos Reneaux
Brusque, Santa Catarina, 8835404, Brazil
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Hospital Kajang
Kajang, Selangor, 43000, Malaysia
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Hospital Kuala Lumpur
Kuala Lumpur, Kuala Lumpur, 42896, Malaysia
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Hospital Pakar Sultanah Fatimah
Muar town, Johor, Malaysia
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Hospital Pulau Pinang
George Town, Pulau Pinang, 10990, Malaysia
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Hospital Sultanah Aminah, Johor Bahru
Johor Bahru, Johor, 80100, Malaysia
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Hospital Sultanah Nur Zahirah Kuala Terengganu
Kuala Terengganu, Kuala Terengganu, 33158, Malaysia
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Hospital Taiping
Taiping, Perak, 34000, Malaysia
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Hospital Tengku Ampuan Afzan, Kuantan
Kuantan, 29142, Malaysia
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Hospital Tengku Ampuan Rahimah Klang
Klang, Selangor, 41200, Malaysia
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Hospital Tuanku Jaafar, Seremban
Seremban, 25167, Malaysia
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Hospital de Clinicas de Porto Alegre
Porto Alegre, Rio Grande do Sul, 90035-903, Brazil
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Huai'an First Peoples Hospital
Huai'an, China
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Humber River Health
Toronto, Ontario, Canada
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Instituto Pro Renal Brazil
Curitiba, Paraná, 80440-020, Brazil
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Irmandade da Santa Casa de Misericordia de Porto Alegre -ISCMPA
Bairro Santa Teresa, Porto Alegre, 90020090, Brazil
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K S Hegde Medical Academy
Mangaluru, Karnataka, 575018, India
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Kelowna General Hospital
Kelowna, British Colombia, V1Y 1T2, Canada
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Kings College Hospital
London, London, SE5 9RS, United Kingdom
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Leicester General Hospital
Leicester, United Kingdom
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Liverpool University Hospitals
Liverpool, United Kingdom
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Madras Medical College Chennai
Park Town, Chennai, 600003, India
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Medical School of Botucatu of the Paulista State University - UNESP
Rubião Júnior, Botucatu, 18618-687, Brazil
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Memorial Service Hospital
Istanbul, Turkey (Türkiye)
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Monash Health
Clayton, Victoria, 3168, Australia
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Nanjappa Hospitals Shimoga
Shimoga, Karnataka, 577201, India
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Narayana Hrudayalaya Limited
Bangalore, Karnataka, 560099, India
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National Health and Education Society
Mumbai, Maharashtra, 400016, India
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National Kidney and Transplant Institute
Quezon City, Manila, 1101, Philippines
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Nefromedic SA
Quito, Pichincha, 170601, Ecuador
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Ninewells Hospital
Dundee, DD1 9SY, United Kingdom
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Nizams Institute of Medical Sciences
Hyderabad, Telangana, 500082, India
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North Shore Hospital
Takapuna, Auckland, 0620, New Zealand
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Northern Beaches Hospital
Frenchs Forest, New South Wales, 2086, Australia
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Osmangazi University
Eskişehir, Turkey (Türkiye)
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Osmania General Hospital
Hyderabad, Telegana, 500012, India
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Ottawa Hospital Research Institute
Ottawa, Ontario, K1Y 4E9, Canada
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PROCARDIO Clinica Cardiologica
Blumenau, South Carolina, 89010500, Brazil
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Palmerston North Hospital
Palmerston North, 4442, New Zealand
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Peking University First Hospital
Beijing, Beijing Municipality, China
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Peking University Peoples Hospital
Beijing, Beijing Municipality, China
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Penticton Regional Hospital
Penticton, British Columbia, Canada
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Peoples Hospital of Yuxi City
Yuxi, China
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Peoples Hospital of Zhongwei
Zhongwei, China
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Philippines General Hospital
Ermita, Manila, 1000, Philippines
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Praxis Pesquisa Medica S/S
Santo André, São Paulo, 09090 790, Brazil
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Princess Alexandra Hospital
Woolloongabba, Queensland, 4102, Australia
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Queen Elizabeth II Health Science Centre
Halifax, Nova Scotia, B3H 1V7, Canada
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Queen Elizabeth University Hospital
Glasgow, Glasgow, G51 4TF, United Kingdom
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Queens University at Kingston General Hospital, Division of Nephrology
Kingston, Ontario, Canada
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Royal Brisbane Women's Hospital
Herston, Queensland, 4029, Australia
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Royal Derby Hospital
Derby, DE22 3NE, United Kingdom
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Royal Inland Hospital
Kamloops, British Colombia, V2C 2T1, Canada
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Royal North Shore Hospital
Wahroonga, New South Wales, 2076, Australia
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Royal Stoke University Hospital
Stoke-on-Trent, United Kingdom
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SEDIC Center
Montevideo, Montevideo Department, 11800, Uruguay
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Salford Royal Hospital
Salford, Salford, M6 8HD, United Kingdom
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Santa Casa de Misericordia de Belo Horizonte
Santa Efigênia, Belo Horizonte, 30150221, Brazil
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Santa Casa de Misericordia de Ponta Grossa
Ponta Grossa, Brazil
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Santa Casa de Misericordia de Votuporanga
Votuporanga, São Paulo, 15500003, Brazil
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Servico Ubaense de Nefrologia Ltda
Ubá, Minas Gerais, 36500008, Brazil
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Seven Star Hospital
Nagpur, India
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Shanghai Tongji Hospital
Shanghai, China
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Shanxi Provincial Peoples Hospital
Shanxi, China
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Shuyang County Hospital of Traditional Chinese Medicine
Suqian, China
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Sihong County Fenjinting Hospital
Suqian, China
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Sociedade Hospitalar Angelina Caron
Campina Grande do Sul, Paraná, 83430000, Brazil
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South Tees James Cook Hospital
Middlesbrough, United Kingdom
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Southmead Hospital
Bristol, Bristol, BS10 5NB, United Kingdom
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St. Joseph's Healthcare
Hamilton, Ontario, L8N 4A6, Canada
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St. Josephs, Toronto
Toronto, Ontario, M6R 1B5, Canada
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St. Michael's Hospital
Toronto, Ontario, M5B 1W8, Canada
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St. Pauls Hospital
Vancouver, British Colombia, V6Z 1Y6, Canada
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Sunshine Coast University Hospital
Birtinya, Queensland, 4575, Australia
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Sydney Adventist Hospital
Wahroonga, New South Wales, 2076, Australia
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The Central Hospital of Enshi Tujia and Miao Autonomous Prefecture
Enshi, China
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The First Affiliated Hospital of Baotou Medical College
Baotou, China
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The First Hospital of Kunming
Kunming, China
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The Royal London Hospital
London, London, E1 2ES, United Kingdom
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The Sir Mortimer B. Davis Jewish General Hospital
Montreal, Quebec, Canada
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Tianjin Fifth Central Hospital
Tianjin, China
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Tianjin Third Central Hospital
Tianjin, China
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Tongiao City Hospital
Tongliao, China
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Ulster Hospital
Dundonald, Belfast, BT16 1RH, United Kingdom
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University Hospital of Whales Health Park
Cardiff, Cardiff, CF14 4XW, United Kingdom
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University Malaya Medical Centre (UMMC)
Kuala Lumpur, Kuala Lumpur, 59100, Malaysia
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University of Alberta
Edmonton, Alberta, T6G 2G3, Canada
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Victoria Hospital
London, Ontario, N6A 5W9, Canada
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Vijaya Hospital
Chennai, Tamil Nadu, 600026, India
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Waikato Hospital
Hamilton, Waikato Region, 3204, New Zealand
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Western Health - Sunshine Hospital
Saint Albans, Victoria, 3021, Australia
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Whangarei Hospital
Whangarei, 0148, New Zealand
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Xinxiang First Peoples Hospital
Xinxiang, China
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Yichuan County Traditional Chinese Medicine Hospital
Luoyang, China
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