Engineered blood vessel could simplify dialysis for kidney patients

NCT ID NCT03183245

Completed Disease control Sponsor: Humacyte, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This phase 3 trial tested a lab-grown blood vessel (Human Acellular Vessel, or HAV) against the standard surgically created fistula in 242 people with end-stage kidney disease on hemodialysis. The goal was to see which option works better for providing reliable access to filter blood. The study measured how well each access type functioned at 6 months and how long it lasted without being abandoned.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Human Acellular Vessel (HAV)
What this could lead to: If it works, this could provide a reliable, ready-to-use option for dialysis access, reducing the need for multiple surgeries.
What could go wrong: This is a completed phase 3 trial, but the HAV may not work as well as a natural fistula for everyone, and there are risks of infection or blockage.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

chronic kidney disease end stage renal failure kidney failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

END-STAGE RENAL DISEASE HEMODIALYSIS RENAL FAILURE VASCULAR ACCESS

Contacts and locations

Locations

Alliance Research

Laguna Hills, California, 92653, United States
Arizona Kidney Disease and Hypertension Center (AKDHC)

Phoenix, Arizona, 85012, United States
Balboa Nephrology

San Diego, California, 92123, United States
Brigham and Women's Hospital

Boston, Massachusetts, 02115, United States
Coastal Vascular & Interventional, PLLC

Pensacola, Florida, 32503, United States
Decatur Memorial Hospital

Decatur, Illinois, 62526, United States
Denver Health Medical Center

Denver, Colorado, 80204, United States
Grady Memorial Hospital

Atlanta, Georgia, 30303, United States
Huntington Hospital

Pasadena, California, 91105, United States
Kaiser Permanente Sunnsyide

Portland, Oregon, 97015, United States
Kidney Care & Transplant Services of New England

West Springfield, Massachusetts, 01089, United States
Memorial Healthcare System

Pembroke Pines, Florida, 33021, United States
Mills Peninsula Hospital

San Mateo, California, 94401, United States
Olive View- UCLA Medical Center

Sylmar, California, 91342, United States
Overlook Medical Center

Summit, New Jersey, 07901, United States
Rutgers University

Newark, New Jersey, 07103, United States
South Plains Surgery Center

Lubbock, Texas, 79416, United States
Surgical Specialists of Charlotte

Charlotte, North Carolina, 28207, United States
Tampa General Hospital

Tampa, Florida, 33606, United States
The Regional Medical Center

Orangeburg, South Carolina, 29118, United States
The Vascular Experts

Darien, Connecticut, 06820, United States
UC Davis

Sacramento, California, 95817, United States
United Surgical Associates

Lexington, Kentucky, 40504, United States
University of Arizona

Tucson, Arizona, 85724, United States
University of CA, San Diego - LaJolla VA Hospital

La Jolla, California, 92161, United States
University of California San Diego, Jacobs Medical Center

La Jolla, California, 92103, United States
University of California, Irvine

Irvine, California, 92868, United States
University of Southern California

Los Angeles, California, 90033, United States
University of Tennessee Knoxville

Knoxville, Tennessee, 37920, United States
VA Long Beach Healthcare System

Long Beach, California, 90822, United States
VA Pittsburgh

Pittsburgh, Pennsylvania, 15213, United States

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