Zapping kidney nerves may tame tough blood pressure
NCT ID NCT04264403
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested a device that uses ultrasound to calm overactive nerves in the kidneys, which can drive high blood pressure. Researchers enrolled 44 people with stage 3 chronic kidney disease and uncontrolled hypertension. Half received the real procedure, half a sham, to see if it safely lowers 24-hour blood pressure readings.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- renal denervation device (Paradise® System) that uses ultrasound energy to calm kidney nerves
- What this could lead to
- If it works, this could offer a new way to control blood pressure in people with chronic kidney disease without adding more pills.
- What could go wrong
- This was a small, early feasibility study with only 44 participants, so results may not apply to everyone. The procedure carries risks like blood vessel damage or infection.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Clinical Research Center Nuremberg, Department of Nephrology, University Hospital Erlangen
Nuremberg, Germany
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Clinical Research Center, Department of Nephrology and Hypertension, University of Erlangen-Nuremberg
Erlangen, 91054, Germany
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Heinrich Heine University Düsseldorf, Nephrologie, Germany
Düsseldorf, 40225, Germany
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Klinik für Innere Medizin III, Kardiologie, Angiologie Und Internistische Intensivmedizin, Saarland University Hospital, Saarland University
Homburg, 66421, Germany
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