New pill shows promise for Tough-to-Treat blood pressure in kidney patients
NCT ID NCT06150924
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This phase 2 trial tested whether adding the experimental drug lorundrostat to standard SGLT2 inhibitor therapy can lower blood pressure in adults with chronic kidney disease and albuminuria (protein in urine). Sixty participants received either lorundrostat or a placebo for four weeks, then switched. The study is complete, and results will show if the drug safely improves blood pressure control.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Lorundrostat (an aldosterone synthase inhibitor) taken as a pill once daily
- What this could lead to
- If successful, this could point toward a new add-on treatment to better control blood pressure and protect kidney function in people with chronic kidney disease.
- What could go wrong
- This is a small, early-phase trial with only 60 participants and short treatment periods. Results may not apply to everyone, and the drug may cause side effects or fail to show clear benefit.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Academic Medical Research Institute (AMRI) - Los Angeles
Los Angeles, California, 90022, United States
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American Clinical Trials Llc
Acworth, Georgia, 30101, United States
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Amicis Research Center
Northridge, California, 91324, United States
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Amicis Research Center - Granada Hills
Granada Hills, California, 91344, United States
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Amicis Research Center - Vacaville
Vacaville, California, 95687-3560, United States
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Arizona Kidney Disease & Hypertension Centers (AKDHC) - Thomas Office
Phoenix, Arizona, 85016, United States
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Arizona Kidney Disease & Hypertension Centers (AKDHC) - Thunderbird Office
Glendale, Arizona, 85306, United States
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Balboa Nephrology Medical Group, Inc. (BNMG) - California Institute of Renal Research (CIRR) - Chula Vista
Chula Vista, California, 91910, United States
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Balboa Nephrology Medical Group, Inc. (BNMG) - El Centro
El Centro, California, 92243, United States
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Balboa Nephrology Medical Group, Inc. (Bnmg) - La Mesa
La Mesa, California, 91942-3059, United States
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Chrysalis Clinical Research (CCR)
St. George, Utah, 84790, United States
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ClinCept, LLC
Columbus, Georgia, 32896, United States
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Colorado Kidney Care (Denver Nephrology) - Denver Office
Denver, Colorado, 80218-1216, United States
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Columbia Nephrology
Columbia, South Carolina, 29203, United States
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Dallas Nephrology Associates (Dna) - Renal Disease Research Institute (Rdri)
Dallas, Texas, 75235, United States
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E T Nephrology Associates - Lufkin
Lufkin, Texas, 75904, United States
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Elixia Central Florida, LLC
Orlando, Florida, 32806, United States
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Elixia MKC, LLC
Pontiac, Michigan, 48341, United States
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Elixia Pines, LLC
Hollywood, Florida, 33024, United States
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Gamma Medical Research, Inc
Mission, Texas, 78572, United States
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Genesis Clinical Research - Tampa
Tampa, Florida, 33614, United States
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Georgia Nephrology, Llc
Lawrenceville, Georgia, 30046-8761, United States
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Indago Research and Health Center
Hialeah, Florida, 33012, United States
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Infigo Clinical Research, Llc
Sanford, Florida, 32771, United States
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Kansas City Kidney Consultants (Arms, Dodge, Robinson, Wilber & Crouch, Inc.) - Kansas City
Kansas City, Missouri, 64111, United States
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Lcms Health University Medical Center New Orleans
New Orleans, Louisiana, 70112-3018, United States
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Liberty Research Center
Dallas, Texas, 75237, United States
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Mendez Center for Clinical Research, LLC
Woodbridge, Virginia, 22191, United States
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Nephrology Associates
Fresh Meadows, New York, 11365, United States
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Nephrology Associates of Kentuckiana, PSC (NAK)
Louisville, Kentucky, 40205, United States
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Nephrology Associates, PC
Fresh Meadows, New York, 11365, United States
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Nephrology Associates, Pllc - Winston-Salem
Winston-Salem, North Carolina, 27103, United States
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Nephrology Consultants - Oklahoma City
Oklahoma City, Oklahoma, 73116-1516, United States
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Nephrology of the Golden Isles - Brunswick
Brunswick, Georgia, 31520, United States
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Northwest Louisiana Nephrology, Llc - Shreveport
Shreveport, Louisiana, 71101, United States
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Palm Beach Diabetes and Endocrine Specialists, PA (PBDES) - West Palm Beach Office
West Palm Beach, Florida, 33401, United States
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Prx Research
Mesquite, Texas, 75149, United States
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Qway Research
Coconut Grove, Florida, 33133, United States
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R&H Clinical Research
Katy, Texas, 27205, United States
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Seacoast Kidney & Hypertension Specialists - Portsmouth Office
Portsmouth, New Hampshire, 03801, United States
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Southeast Renal Research Institute
Chattanooga, Tennessee, 37408, United States
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Suny Downstate Medical Center - Parkside Dialysis Center
Brooklyn, New York, 11226-1508, United States
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Triad Internal Medicine
Asheboro, North Carolina, 27205, United States
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Tufts University School of Medicine (Tusm) - Tufts Medical Center (Tmc) (Tufts-New England Medical Center)
Boston, Massachusetts, 02111, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Aging kidneys under the microscope: could a simple test predict failure?
- Could your gut bacteria hold the key to protecting your kidneys?
- Food as medicine: could cooking classes slow kidney disease?
- Could a phone app be the key to managing kidney disease?
- A new pill aims to slow kidney failure and save lives
- AI takes on kidney disease: a new model to forecast Who's at risk