Chronic kidney disease

This study tested a liquid medicine called paricalcitol in children aged 0 to 9 years with severe kidney failure who are on dialysis. The goal was to see if it safely lowers high parathyroid hormone levels, a common complication. The trial was stopped early after enrolling only 2…

This pilot study tested two diuretics (furosemide and chlorthalidone) in people on dialysis who still had some kidney function. The goal was to see if these water pills could help preserve remaining kidney function, increase urine output, and reduce weight gain between dialysis s…

This study looked at whether hyperbaric oxygen therapy (breathing pure oxygen in a pressurized chamber) could help people with diabetic kidney disease. The goal was to see if it could improve kidney function and reduce protein in the urine. However, the study was stopped early an…

This small Phase 2 study tested two doses of vonafexor, an oral drug, in 10 people with mild-to-moderate chronic kidney disease and suspected MASH (a type of fatty liver disease). The goal was to see if vonafexor could improve kidney function. However, the trial was terminated ea…

This small pilot study tested whether a low-carb diet (50-100 grams of carbs per day) combined with the diabetes drug dapagliflozin could improve blood sugar control in people with chronic kidney disease and prediabetes or type 2 diabetes. Four participants were split into two gr…

This trial tested a smartphone app (SKI App) that uses blockchain and AI to help dialysis patients track their health data and get personalized care tips. The goal was to see if the app could reduce emergency room visits and hospital stays compared to a basic health app. The stud…

This phase 2 study tested a weekly extended-release capsule of calcifediol (CTAP101) in 44 adults with chronic kidney disease on hemodialysis who also had vitamin D insufficiency and secondary hyperparathyroidism. The goal was to see if the drug could raise vitamin D levels and l…

This study looked at whether a blood test called ImmuKnow can help doctors better manage anti-rejection drugs in kidney transplant patients. The goal was to reduce infections while still preventing organ rejection. Only 4 patients were enrolled before the study was stopped early,…

This study looked at whether taking a daily low-dose aspirin could help people with chronic kidney disease avoid their first heart attack or stroke. Over 4,600 participants were randomly assigned to take aspirin or receive usual care. The trial was stopped early, and the final re…

This study tested a drug called siplizumab combined with donor bone marrow cells to help kidney transplant patients potentially stop taking anti-rejection drugs long-term. Only 4 people took part before the study was ended early. The goal was to find the best dose to safely allow…

This study tested a drug called sodium zirconium cyclosilicate (SZC) to see if it could slow down chronic kidney disease (CKD) in people who also have high potassium levels. Over 1,100 adults with moderate-to-severe CKD took SZC or a placebo alongside their regular blood pressure…

This study tested two drugs, daratumumab and belatacept, in 5 highly sensitized dialysis patients waiting for a kidney transplant. The goal was to safely reduce the antibodies that make it very hard to find a compatible donor kidney. The trial was stopped early, but it aimed to h…

This study looked at whether two drugs, finerenone and empagliflozin, can slow kidney function decline in people at high risk for chronic kidney disease after having a kidney removed for cancer. Ten participants took one or both drugs or no drug for a year. The trial was terminat…

This study tested a device called everlinQ endoAVF that creates a connection between an artery and a vein using a thin tube (catheter) instead of open surgery. The goal was to make it easier for people with chronic kidney disease to get dialysis. The trial enrolled 100 adults who…

This study tested a drug called OMS721 for people with IgA nephropathy, a kidney disease that can lead to kidney failure. The goal was to see if the drug could reduce protein in the urine, a sign of kidney damage. The trial was stopped early, so results are limited.

This study tested whether the drug heme arginate can help transplanted kidneys work right away, instead of being slow to start. It included 47 adults receiving a kidney from a deceased donor. Participants got either the drug or a salt water solution at transplant and 24 hours lat…

This study tested whether a drug called imlifidase, given with other medications, could prevent the immune system from attacking a new kidney in highly sensitized patients. These patients have a very high risk of rejecting a donated kidney. The study was stopped early after only …

This early study tested a new drug called AZD5462 added to the standard medicine dapagliflozin in people with heart failure and moderate kidney disease. Only 8 participants were enrolled before the study was stopped. The goal was to see if the combination is safe and affects how …

This early study tested a drug called isatuximab in 23 people waiting for a kidney transplant. The goal was to see if it could safely lower immune antibodies that make it hard to find a matching donor. The trial was stopped early, so we have limited information on how well it wor…

This study tested a drug called KBP-5074 in 652 adults with moderate-to-severe chronic kidney disease and high blood pressure that was not controlled by at least two other medications. Participants received either KBP-5074 or a placebo daily for up to 52 weeks to see if the drug …

This study investigates why people with advanced chronic kidney disease (stages 3b to 5) often feel tired and weak. Researchers measure handgrip strength and muscle electrical signals in patients aged 60 and older, comparing them to healthy individuals of the same age and sex. Th…

This study looked at whether special eye scans (OCT-angiography) can predict how well the remaining kidney will work one year after kidney removal for cancer. Researchers enrolled 30 adults scheduled for total nephrectomy. The goal was to see if retinal blood vessel patterns coul…

This study looked at how the drug tacrolimus, often used after kidney transplants, affects blood sugar and insulin in people with kidney failure who are waiting for a transplant. Researchers wanted to find early signs of diabetes risk so doctors could adjust treatment. The study …

This study aimed to find substances in blood and urine that could signal kidney damage earlier than current tests. Researchers compared samples from healthy volunteers, people with low fluid levels, those at high risk for kidney failure, and patients with acute kidney failure. Th…

This study compared survival in people with end-stage kidney disease who were randomly assigned to either peritoneal dialysis or hemodialysis. The goal was to see which type of dialysis leads to longer life and fewer complications. The study was conducted in China and was termina…

This study aimed to see if teaching chronic kidney disease patients about their condition in a pharmacy could help them choose a dialysis type or consider a transplant. It was designed for adults in Arkansas who were not yet on dialysis. The study was stopped early after only one…

This study looked at why erythropoietin (EPO), a drug used to treat anemia, can raise blood pressure in people with chronic kidney disease. Researchers planned to enroll 160 participants but stopped early with only 27. The goal was to measure changes in blood pressure and blood v…

This pilot study tested a home-based conservative care program for veterans with advanced chronic kidney disease who chose not to start dialysis. The program involved a team of doctors, nurses, and other specialists providing care at home. Only 2 participants were enrolled before…

This pilot study aimed to compare two standard surgical methods for creating an arteriovenous (AV) fistula in the arm for dialysis patients with kidney failure. The goal was to see if a single procedure or two separate procedures leads to better outcomes and quality of life. Howe…